Dear colleagues and friends!

Background. Anti-inflammatory therapy is used to achieve and maintain asthma control, as well as respiratory function indicators monitoring. Telemedicine technologies can be used for this purpose, and it became particularly essential during the COVID-19 pandemic.

Objective. The aim of the study is to analyze efficacy of the mobile technology MedQuizBot for asthma monitoring, to estimate patient compliance to use such instruments of self-control via the bot and without it, and bot's functioning satisfaction.

Methods. 6-month prospective observational comparative study in patients with asthma from 4 to 17 years old was conducted. All patients were divided into two groups: patients who have used MedQuizBot and patients who have used any other self-control tools. Patients had to enter peakflowmetry data daily and undergo asthma control tests monthly. Patients were able to communicate with their doctor remotely via the chat bot. Main study indicators: determining the efficacy of MedQuizBot in patients with asthma by estimating the compliance to self-control tools at using the bot. Secondary study indicators: estimation of patients satisfaction on using the MedQuizBot and determination of level of asthma control due to the obtained data results.

Results. 41 patients have used MedQuizBot, 27 patients were in the control group. Patients who used the bot more often answered asthma control test questions. Patients over 12 years old have completed the asthma control test less often than young children: ACT was filled on average in 1.5 times, САСТ — 1.8 times. 51% of patients filled in data on peakflowmetry via the new technology, patients from control group did not start the picflowmetry diary. Patients under 12 years old, who filled up the test with their parents, has entered picflowmetry data 7 times more often than adolescents. The asthma was under control in 70% of patients. The data was entered into the system 2.5 times more often during the lockdown period due to COVID-19 pandemic and during the tree flowering season in comparison to other periods of2020. Patients noted the usability of the MedQuizBot and agreed to use it in future.

Conclusion. MedQuizBot is effective in achieving asthma control mainly during the period of need — in case of insufficient control over the disease itself (exposure to pollen allergens, acute respiratory diseases), during the limitations in medical care availability.

Nowadays there is progressive increase in the number of patients with allergy around the world. It was revealed that microbiome composition changes at early age correlate with the frequency of atopic diseases development. Various clinical studies have shown that variety of factors (even from prenatal development) influence microbiota composition. Children with atopic diseases have certain features of microflora development that can precede the disease debut. Cow’s milk protein is one of the major allergens in the first year of life. Such sensitization may be present in children on both formula and breastfeeding, however it is not the indication for its interruption. In cases when breastfeeding is not possible, we should use specialized therapeutic formulas in children with cow’s milk protein allergy. The use of the “Nutrilon Amino acids Syneo" formula effectively eliminates allergy symptoms and improves the gut microbiota composition in young children. Moreover, its use additionally reduce the frequency of infectious diseases and the use of antibacterial drugs.

Papillomavirus infection (HPV infection) is the leading sexually transmitted infection in prevalence. HPV infection and associated diseases, including cancer, remain one of the global problems of our time. This literature review presents relevant data from foreign studies and domestic works on the state of HPV vaccination in the world, the modern vaccines efficacy for the HPV-associated diseases prevention, current vaccination strategies and their efficacy as well. The aim of the article is to determine the advantages of using gender-neutral vaccination strategy over priority-used vaccination strategy for girls only in the prevention of HPV-associated diseases, including cancer, as well as for eradicating HPV infection in general.

The article presents modern data on the epidemiology, etiology and clinical manifestations of food allergies in children. Evidence-based approaches to diagnosis, including differential, treatment, and prevention of food allergies in children are shown. Patient management tactics and algorithms are presented in detail. The guidelines are based on all available up-to-date data on food allergies. The material is based on the methodological guideline for the management of patients with food allergies previously developed by expert specialists of the Union of Pediatricians of Russia in 2021.

The results of a historical and medical study reflecting the issues of combating dysentery and other acute enteric infections among the children in Soviet Russia during the 1930-1940 period are presented in this article. Analysis of medical reports, orders, circular letters of the People’s Commissariat of Health Сare of the USSR and other documents from published and unpublished archival materials, and scientific publications of Soviet scientists indicate that the situation with dysentery and other acute intestinal infections among children (especially of early age) was complicated and characterized by significant prevalence of this pathology in the 1930s. This study has shown that it was possible to reduce children morbidity and mortality due to the implementation of extensive sanitary, hygienic and anti-epidemic measures on the government level, the implementation of specialized dietary products for kids and new methods of therapy (sulfanilamides, dysenteric bacteriophage, antidisenteric serum) in Moscow and other regions (for example in Gorky and Kirov regions). The experience of organizing the pediatricians, epidemiologists, health care organizers work against acute enteric infections among children in Soviet Russia in the 1930s can currently be used in various countries and regions where acute diarrheal diseases are significant cause of children mortality.

The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E. coli, has become the crucial part in the protocols for the treatment of ALL in children and adults since the 1960s-1970s due to its antitumor effect on lymphoid leukemia cells. Despite the evolution of therapeutic approaches in ALL management, changes in used chemotherapeutic agents, their administration regimens and doses, the asparaginase remains one of the leading therapeutic agents in ALL patients. With time ideas about the asparaginase mechanisms have expanded, new data have been accumulated on adverse effects (allergic reactions, thrombotic complications, pancreatitis, hepatic dysfunction, etc.). The asparaginase obtained from Erwinia chrysanthemi and PEGylated forms of the drug were used to reduce the frequency of any of such adverse effects. This literature review provides current concepts on the mechanism of L-asparaginase dosage forms action, describes side effects associated with the use of this medication. We also present our own clinical case of L-asparaginase (obtained from Erwinia chrysanthemi) administration in ALL patient with allergic reaction to PEG-L-asparaginase.