Vol 6, No 5 (2009)
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VACCINATION
6-9 462
Abstract
The article looks at one of the critical issues in modern medicine — human papilloma virus infection. The prevalence of this infection in the world and the possibility of primary prevention in females of various age groups are highlighted in details. It provides the results of vaccine prevention against the human papilloma virus in Russian in girls and women aged 9 to 26 years.
Key words: papilloma virus infection, cervical cancer, women, girls, vaccinal prevention.
Key words: papilloma virus infection, cervical cancer, women, girls, vaccinal prevention.
CASE REPORT
URGENT ISSUES OF A TREATMENT OF EAR, NOSE, THROAT DISEASES
10-13 360
Abstract
The issue of inflammatory diseases of the upper airways and eardrum remains relevant and associated both with high prevalence of this pathology and likelihood of developing complications. Inflammation of nasal cavity’s mucosal lining causes discomfort, while chronic dysfunction of nasal breathing significantly reduces the patient’s quality of life. Difficulty in nasal breathing of newborns and infants results in quite severe complications. Nearly 70% of acute respiratory infections cases in children are complicated with acute inflammation of eardrum, 90% of children under 3 years once develop secretory otitis media, 50% of them have several cases of eardrum inflammation.
Key words: acute respiratory infections, otitis, treatment, children.
Key words: acute respiratory infections, otitis, treatment, children.
REVIEW
14-19 2478
Abstract
Immunomodulatory drugs reduce relapse rate and disease progression in relapsing-remitting multiple sclerosis but extensive data are not available on the effectiveness and tolerability of these drugs in childhood or adolescence. Interferon beta tolerability biased by frequency and method of drug administration. Drug administration has great impact on treatment compliance and adherence. That’s why we discuss moreover interferon beta 1a intramuscular as perspective immunomodulative medication in pediatric MS cohort.
Key words: immunomodulatory drugs, interferon beta, multiple sclerosis, compliance, adherence, adolescence, childhood.
Key words: immunomodulatory drugs, interferon beta, multiple sclerosis, compliance, adherence, adolescence, childhood.
20-29 2951
Abstract
Allergic rhinitis is an allergic inflammation of the nasal mucosa due to sensitization to some inhalation allergens. There are two phases of a systemic allergic reaction depending on interaction of different cell types a biochemical mediators — the early (acute) and the late (chronic). Leukotrienes are primary mediators of the late phase of allergic inflammation. The leukotrienes are a group of derivates of arachidonic acid metabolism. Antagonists of CysLT1 include montelukast, zafirlukast and pranlukast. Recently there were some studies regarding using of antileukotriene drugs for monotherapy of allergic rhinitis. Evidence of efficacy of Montelukast is provided in more than 25 randomized researches.
Key words: allergic rhinitis, leukotrienes, antileukotriene drugs, montelukast.
Key words: allergic rhinitis, leukotrienes, antileukotriene drugs, montelukast.
ORIGINAL ARTICLES
30-33 402
Abstract
The effect of hypoxihypobarotherapy in children with bronchial asthma at the rehabilitation stage on the clinicals and dynamics of immunity response to the disease has been studied. Clinical efficacy of hypoxihypobarotherapy was 63,3% in moderate asthma. Positive dynamics of immunological indicators and neuropeptides have manifested in reduced of IL 4, IL 5, IL 18 and substance P serum levels. Use of hypoxihypobarotherapy in children with bronchial asthma has resulted in favourable clinical and immune dynamics and positive alteration of neurohumoral regulation mechanisms and reduced intensity of neurogenic inflammation. Determining immunological indicators, including neuropeptides, may serve as an additional criterion for assessing the efficacy of this treatment in children with bronchial asthma at the rehabilitation stage.
Key words: children, bronchial asthma, pneumotherapy, hypoxihypobarotherapy, neuropeptides, cytokines.
Key words: children, bronchial asthma, pneumotherapy, hypoxihypobarotherapy, neuropeptides, cytokines.
34-37 553
Abstract
Gut endotoxicosis caused by penetration of bacterial and metabolic toxins from chime on the background of increasing permeability of gut wall is of great importance in pathogenesis of chronic inflammatory bowel diseases (nonspecific ulcerative colitis — NUC and Crohn’s disease). It is accompanied by disturbance of regulating homeostasis system with the following disturbances of organs and systems of toxication. Developed endotoxicosis accordingly contributes to maintain and to progress of metabolic and immunological changes. To obtain the precise degree and phase of development of endotoxicosis we estimated quantitative and qualitative changes of metabolic status in accordance with content in erythrocytes, plasma and urine LMMWP (low and medium molecular weight peptides). Taking into concideration the peculiarities of children endotoxicosis with, we suggested patogenetical absorption therapy. Therefore, the therapeutic complex was added enterosorbent ensoral, which absorb eczo and endogenic toxins and, moreover, positive influence for composition of intestinal microflora. Prominent clinical effect was accompanied by positive dynamics of laboratory-instrumental parameters.
Key words: endogenous intoxication, inflammatory bowel diseases, nonspecific ulcerative colitis, Crohn’s disease, low and medium molecular weight peptides, enterosorbents, children.
Key words: endogenous intoxication, inflammatory bowel diseases, nonspecific ulcerative colitis, Crohn’s disease, low and medium molecular weight peptides, enterosorbents, children.
O.S. Logacheva,
O.V. Kozhevnikova,
L.S. Namazova-Baranova,
A.E. Pal'tseva,
L.A. Ryzhkova,
I.V. Shirokova
38-41 464
Abstract
There is currently an increase in the frequency of cardiovascular diseases which are caused by atherosclerotic vessel impairments, such as myocardial infarction and cardiovascular accident. The purpose of this research is to study the possibility of implement into outpatient pediatric practice the method of arteriography for determining changes in the aortic wall at the early development stage. 2 indicators were measured using arteriography: pulse wave velocity and the augmentation index in healthy children aged 6 to 12 years old. The results obtained in a study of healthy children reliably differ from standardized norms for adults and may be used as references.
Key words: arteriography, atherosclerosis, arterial rigidity, pulse wave velocity, augmentation index, children.
Key words: arteriography, atherosclerosis, arterial rigidity, pulse wave velocity, augmentation index, children.
LECTURE
42-46 532
Abstract
The author focuses on the causes of vitamin deficiency in this article dedicated to the issues of hypovitaminosis in the children population. It also describes the consequences of a vitamin and mineral deficiency in the body. Given the interaction of individual vitamins and minerals, the author demonstrates the best efficacy of complex medications. In addition, the article stresses the need for a preventive administration of these medications ensuring the normal level of minerals and vitamins, and, hence, an optimal functioning of a child’s body organs and systems.
Key words: vitamins, minerals, deficiency, correction ways, children.
Key words: vitamins, minerals, deficiency, correction ways, children.
MATERIALS OF 4TH EUROPEAN PAEDIATRIC CONGRESS «EUROPAEDIATRICS-2009»
For Pediatricians' Practice
61-64 457
Abstract
The issue of creating and preserving normal microecology of intestinal tract is important to children of all age groups. Control over microbiocenosis creation and correction ability in the period of its establishment in children in their first months with a perinatal period pathology deserves special attention.
Key words: newborn, infant, dysbacteriosis, probiotic.
Key words: newborn, infant, dysbacteriosis, probiotic.
65-69 400
Abstract
The purpose of this work was to assess the efficacy of bacterial lysate for prevention of acute respiratory infections. The article provides results of monitoring children in the orphanage who were administered the medication of this group as a prophylactic drug against acute respiratory infections. Children also from orphanages who were not administered the medication were selected as a control group. It was found that out of 80 children who underwent preventive treatment, only 26 children fell ill, while out of 80 children in the control group so did 78 orphans. The results achieved allowed the topical immunologic response modifier to be recommended as a general preventive medication for wide use in children in the period of seasonal respiratory infection incidence rate pickup.
Key words: influenza, acute respiratory infections, preventive treatment, children.
Key words: influenza, acute respiratory infections, preventive treatment, children.
70-75 551
Abstract
Functional dysmotility is one of the most common evidence of pathology in gastrointestinal tract (GIT). GIT motility regulation is multilevel in nature at the level of central and peripheral nervous system, vegetative nervous system as well as locally directly in the intestinal tract. Gastrointestinal tract microbiota significantly contributes to the local regulation of motility both by forming fecal masses and secreting various metabolites, particularly short chain fatty acids whose composition and number depends on the nutritive factors of microbiota. For normal functioning and metabolism, saprophitic microbiota needs a significant number of undigestible carbohydrates, i.e. prebiotics. Prebiotics are an integral component of the complex therapy for functional impairments of gastrointestinal tract.
Key words: gastrointestinal tract, motility, functional impairments, mictobiota, short chain fatty acids, prebiotics, lactulose.
Key words: gastrointestinal tract, motility, functional impairments, mictobiota, short chain fatty acids, prebiotics, lactulose.
76-78 570
Abstract
Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.
Key words: encopresis, differential diagnostics, treatment, children.
Key words: encopresis, differential diagnostics, treatment, children.
80-84 498
Abstract
Carditis has a special place among diphtheritic complications determining a disease prognosis. The article provides results of studying a functional status of cardiac muscle in children who have had diphtheritic complications in the short-term (2–3 years; n = 35) and longterm (9–10 years; n = 15) follow-up. Echo cardiographic test showed there were three hemodynamic options available for diphtheritic carditis development: normal volumetric parameters of the left ventricle cavity; an enlarged left ventricle cavity and reduced myocardial contractility (dilated cardiomyopathy); a reduced left ventricle cavity with intact myocardial contractility (diastolic dysfunction). Including vitamin E and Carnitine chloride into the treatment for children who have had Diphtheritic Carditis results in improvements both to the cardiac systolic and diastolic functions.
Key words: children, diphtheritic carditis, cardiac remodelling, cardiomyopathy, diastolic function.
Key words: children, diphtheritic carditis, cardiac remodelling, cardiomyopathy, diastolic function.
FROM THE UNION OF PEDIATRICIANS OF RUSSIA
SHORT REPORT
TRAINING FOR TRAINERS — EDUCATIONAL PROGRAM FOR PARENTS
110-112 1481
Abstract
Bronchial asthma is a chronic inflammatory disease of respiratory tract. Breastfeeding mothers suffering from bronchial asthma require attention and control over their health status. The results of research described in the article confirm the need for a continued baseline therapy using the inhalant budesonide in the breastfeeding period and allow mothers suffering from bronchial asthma to be sure of safety in application of modern optimal anti-inflammatory disease treatment and not to worry about a possibility of systemic effect of the medication on the baby.
Key words: budesonide, inhalant glucocorticosteroids, breast milk.
Key words: budesonide, inhalant glucocorticosteroids, breast milk.
ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)
ISSN 2500-3089 (Online)
