Vol 4, No 3 (2007)
View or download the full issue
PDF (Russian)
AN EDITORIAL ARTICLE
98-109 340
ORIGINAL ARTICLES
T.V. Strokova,
O.S. Gundobina,
A.B. Galich,
T.B. Sentsova,
E.L. Tumanova,
V.M. Senyakovich,
A.S. Potapov,
B.S. Kaganov
6-12 1826
Abstract
The article demonstrates the results of the clinical efficiency and tolerance of different antiviral therapy schemes (interferon, lamivudin and their combination) among children with chronic hepatitis b. the comparative research involved 85 children, who underwent the examination of the biochemical blood analysis, hepatitis b markers (Elisa, PCR), histological study of the liver tissues.
Key words: children, chronic hepatitis b, interferon, lamivudin.
Key words: children, chronic hepatitis b, interferon, lamivudin.
13-16 440
Abstract
This article is dedicated to the burning issue, which is the impact of the long term treatment for allergic rhinitis on the quality of life of patients and their family members. It was uncovered that practically all the children, suffering from allergic rhinitis, experienced certain phenomena of the social deadaptation and decreased quality of life. in the meantime, the adequate anti-inflammatory therapy for the acute allergic rhinitis is conducive to better quality of life of children and their family members, while the prescription of a cognitive nootrop — hopantenic acid together with the basic anti-inflammatory therapy for the all year allergic rhinitis by means of mometasone much more efficiently improves the quality of life of children, suffering from persistent allergic rhinitis.
Key words: allergic rhinitis, children, hopantenic acid, mometasone, treatment.
Key words: allergic rhinitis, children, hopantenic acid, mometasone, treatment.
E.I. Gusev,
O.A. Gromova,
A.A. Nikonov,
E.V. Uvarova,
T.R. Grishina,
L.E. Fedotova,
O.A. Limanova,
A.Yu. Volkov
18-25 568
Abstract
The serum level of magnesium was evaluated in 232 teenagers and adolescents with early cerebrovascular diseases aged 16–21 years. In cases of magnesium deficiency, monotherapy with complex magnesium medication is an effective treatment both for concurrent magnesium deficiency and for early forms of cerebrovascular pathology with different patterns of vascular response (hyper_ and hypoconstrictive variants). Maximum normotensive effect of the therapy and maximal efficacy in treating vertigo and headaches is reached in combinational therapy with vinpocetin and complex magnesium medication. a combination of complex magnesium medication with bylobil potentiates antiasthenic effect, mostly through diminishing excessive neuron muscular irritability and paresthesiae.
Key words: teenagers, magnesium, b6 vitamin, cavinton, bylobil, potentiative therapy, early forms of cerebrovascular diseases.
Key words: teenagers, magnesium, b6 vitamin, cavinton, bylobil, potentiative therapy, early forms of cerebrovascular diseases.
26-34 746
Abstract
Acute respiratory infections are one of the main reasons for the morbidity among children. In this respect, one of the urgent trends in the modern medicine is believed to be prophylaxis of these diseases, including immunostimulant aided prevention. However, use of the medications from this group is highly debatable. Like wise many doctors skeptically view their use. The objective of the conducted research was to analyze the international clinical research with immunostimulants among children from the evidentbased medicine viewpoint. As a result of the electronic research, the authors have found out 122,189 links, 88 of which were identified as clinical research. As a consequence, the analysis incorporated 34 research works, comprising 3,727 children and 1 meta analysis. Due to the high prevalence of the methodic drawbacks during the clinical research, the efficiency calculation was conducted only on the basis of the data on the bacterial immuno stimulants. The work showed that they would decrease the general number of the respiratory infections by 1,7 (95% confidence interval of 1,54–1,86). The frequency of the unwanted effects was pretty low and no different from placebo groups. The authors believe that it is necessary to conduct Russian randomized placebo controlled multi centered clinical research among children to finally clarify the efficiency and safety of immuno stimulants for the prevention of the respiratory infections.
Key words: immunostimulants, аcute respiratory tract infections, children.
Key words: immunostimulants, аcute respiratory tract infections, children.
O.N. Bryantseva,
E.E. Tikhomirov,
N.V. Zhurkova,
N.I. Voznesenskaya,
G.M. Bayazutdinova,
N.S. Aver'yanova,
I.I. Balabolkin,
V.G. Pinelis
35-39 481
Abstract
The variability of the pharmacological response to β2-agonists may be due to the polymorphism of the gene of β2-adrenergic receptor (ADRβ2). The objective of our research was to evaluate the significance of ADRβ2 gene polymorphism in the 16th amino acid position in the efficiency of broncholytic therapy by β2-agonists agonists among children with bronchial asthma. We defined the type of ADRβ2 gene among 208 children with bronchial asthma of various severity by means of polymerase chain reaction. The distribution of the patients into two groups was carried out subject to the efficiency of the β2-agonists agonist based short term therapy during the exacerbation of bronchial asthma. 171 children received the inhaled glucocorticoids. The researchers singled out statistically significant differences of the genotype distribution. the gly/gly16 homozygous allele was discovered twice as often in the group with an insufficient response to β2-agonists agonists than in the group with a good response (66 v. 38%, р < 0,001), while in the distribution of the heterozygous allele the researchers uncovered the inverse pattern (55 v. 28%, р < 0,001). In the arg/arg16 genotype distribution, there were no considerable differences in both groups (6% in each group). In the subgroups of children, receiving the high doses of the inhaled glucocorticoids, the researchers traced the trend for the gly/gly16 homozygous allele prevalence. conclusions: we have discovered the association of the gly/gly16 genotype of the ADRβ2 gene with an insufficient effect of broncholytic therapy by means of short term β2-agonists agonists; we also revealed the participation of the gly16 allele in the phenotype formation with the severe run of bronchial asthma and to lerance towards the therapy both by β2-agonists agonists and inhaled glucocorticoids.
Key words: bronchial asthma, β2-adrenergic receptor, children, treatment.
Key words: bronchial asthma, β2-adrenergic receptor, children, treatment.
40-44 555
Abstract
Presence of polymorphism in genes coding biotransformation system may play an important role in formation of primary childhood acute leukemia, and affects the incidence and features of relapse. We developed a biological microchip which allows to analyze 14 mutations in eight genes of biotransfor mation system: cyp1a1, cyp2d6, gstt1, gstm1, nat2, mthfr, cyp2c9 and cyp2c19. This biochip has been used to study DNA samples from 332 children with diagnosis of acute lymphoblastic leukemia (all) and 71 children with diagnosis of acute myeloblastic leukemia (AML). it was obtained that variant genotype cyp1a1 *1/*2а more often occur in children with relapse of disease than in children with primary diagnosed leukemia (or = 2,11, p = 0,0291). Also it has been shown, that «null» gstt1 genotype is less frequent in children with relapse of disease than in children with primary diagnosed leukemia (or = 0,55, p = 0,0265). Upon sex stratification, boys with relapse of all demonstrated an increased occurrence of the cyp1a1 genotype *1/*2а in combination with the gstt1 «nonnull» genotype relative to patients with primarily diagnosed all (or = 3,09, p = 0,0254). In addition, girls with relapse of acute leukemia displayed a 2,4_fold lower frequency of the «null» gstm1 genotype as compared with the girls group with primary leukemia (or = 0,41, p = 0,0175). Thus, it was shown that studied genotypes cyp1a1 and GST might be prognostic risk factors of relapse in childhood acute leukemia.
Key words: acute leukemia, drug resistance, cytochrome p 450, glutathione-s-transferases, polymorphism, oligonucleotide biochips.
Key words: acute leukemia, drug resistance, cytochrome p 450, glutathione-s-transferases, polymorphism, oligonucleotide biochips.
45-49 593
Abstract
The authors appraised the diagnostic value (sensitivity, specificity, positive and negative prognostic values) of leukocytes, concentration of c reactive protein, procalcitonin in the blood of children with fever and symptoms of acute tonsillitis. They provided comparative characteristics of these indices during tonsillitises of various etiology. It was stressed that the concentration of leukocytes of 10–15_109/l was not a reliable marker of the bacterial infection, while c reactive protein as a marker of the bacterial inflammation had some average sensitivity and specificity values and procalcitonin had the highest specificity.
Key words: acute tonsillitis, fever, children, leukocytosis, c_reactive protein, procalcitonin.
Key words: acute tonsillitis, fever, children, leukocytosis, c_reactive protein, procalcitonin.
50-55 4047
Abstract
The researchers have examined 45 children aged between 3 and 14, suffering from the lingering recurrent forms of pseudotuberculosis. 25 children (55,6%) received some conventional therapy, whereas 20 patients (44,3%) used interferon alpha_2. The practice demonstrated that the introduction of interferon alpha 2 into the complex therapy of children, suffering from pseudotuberculosis, led to a considerable decrease in the intensity and duration of the main pseudotuberculosis syndromes (intoxication, fever, hepatomegaly, exanthema, arthralgia, gastroenteritis). Clinical efficiency of interferon alpha 2 was con firmed by the positive dynamics of immunological indices. The researchers have uncovered a clear anti recurrent therapy effect: relapses were noted among 5% of patients if compared with 15% within a group of children, who received the conventional therapy.
Key words: pseudotuberculosis, children, interferon Alpha 2.
Key words: pseudotuberculosis, children, interferon Alpha 2.
PHARMACOECONOMICS IN PEDIATRICS
REVIEW
58-66 1217
Abstract
The problem of acute tonsillitis caused by β-hemolytic group a streptococcus is still urgent both in the medical and general practical aspects. The present article highlights the data, which shows «the rebirth» of the highly virulent β-hemolytic group a streptococcal infection and growth of the complications frequency (acute rheumatic fever, toxic shock syndrome). The authors justify the necessity in rational antibacterial therapy against this pathology. The medications to treat acute forms of β-hemolytic group a streptococcal tonsillitis may be chosen among the following: penicillins (amoxicillin et al.) and I generation cephalosporins (cefadroxil), while in case of β-lactam antibiotic intolerance the choice may be shifted to macrolides (spiramycin et al.). In the event of chronic recurrent β-hemolytic group a streptococcal tonsillitis, when chances that bacteria, producing β-lactamases, will colonize the nidus of infection, are rather high, one should apply inhibitor protected penicillins (amoxicillin+clavulanic acid) or II generation cephalosporins (cefuroxime). lincosamins (lincomycin, clindamycin) are used in therapy against acute and chronic β-hemolytic group a strepto coccal tonsillitis as reserve medications.
Key words: β-hemolytic group a streptococcus, acute tonsillitis, acute rheumatic fever, antibiotic therapy.
Key words: β-hemolytic group a streptococcus, acute tonsillitis, acute rheumatic fever, antibiotic therapy.
LECTURE
67-69 527
Abstract
Vitamins are substances of different chemical origin which both provide many biochemical processes within cells, tissues and organs and exert influence on physical and formative functions of the organism. In contemporary conditions peculiarities of the household and children's nourishment do not allow for complete satisfaction of the need in all the vitamins only thanks to the food. vitamins insufficiency may be compensated through the supplementary intake of the children's multivitamin medications.
Key words: vitamins, children, hypovitaminosis, vitamin and mineral complex.
Key words: vitamins, children, hypovitaminosis, vitamin and mineral complex.
70-72 497
Abstract
The author analyzes the efficiency of the children's mass vaccination against flu. It has been revealed that mass vaccination against flu reduces flu sick rate not only among the vaccinated children, but also within the general population. It reduces the frequency of hospitalizations related to complications, arising from influenzal infection, as well as death rate of elderly people caused by flu. The article highlights the economic efficiency estimation of the children's mass vaccination against flu.
Key words: flu, sick rate, vaccination against flu, children.
Key words: flu, sick rate, vaccination against flu, children.
73-79 742
Abstract
Vaccination aided disease control over infection pathology among the children led to elimination of smallpox and poliomyelitis, drastic decrease of the tuberculous meningitis recurrences, tetanus, measles and other infection diseases and their complications. At the same time, Russia is still afraid to apply certain vaccines. The reasons for that are mainly subjective. This is the unjustified caution related to the fear that it may cause severe vaccine associated complications. The data in view of the lecture indicates the safety of the vaccinal prevention procedures and measures for the prevention of their complications.
Key words: vaccinal prevention, vaccination complications, vaccination safety, children.
Key words: vaccinal prevention, vaccination complications, vaccination safety, children.
For Pediatricians' Practice
80-83 564
Abstract
The researchers studied the results of the topical antibacterial therapy of acute pharyngitis among children by means of biclotymol contained medications. The treatment was carried on in two ways: the first group of patients (22 children) was made of those, who received or dispersible pills, containing biclotymol, lysozyme and enoxolone; while in the therapy of children from the second group (24 children) they additionally used biclotymol in the form of a dosing spray. The treatment efficiency proved to be comparable, yet in spite of somewhat subjectively worse to lerance of the combined therapy its application is statistically reliable to quickly improve the pharyngoscopical picture and remove the pain syndrome.
Key words: acute pharyngitis, topical antibacterial therapy, childhood, biclotymol.
Key words: acute pharyngitis, topical antibacterial therapy, childhood, biclotymol.
84-86 466
Abstract
The research is dedicated to the efficiency evaluation of the budesonide based nebuliser therapy to reduce the exacerbation of bronchial asthma among children and teenagers. it was uncovered that the efficiency of such therapy reached 100%, which is manifested both in the decrease of the symptomatology intensity and improvement for the indices of the external respiration function, while there are no side effects whatsoever.
Key words: bronchial asthma, budesonide, nebuliser, children.
Key words: bronchial asthma, budesonide, nebuliser, children.
88-91 393
Abstract
The article deals with the effects of the probiotic medicine among the patients, suffering from chronic adenoiditis. The researchers have received some reliable improvement of the nasal breathing and decrease of the adenoid vegetations. More over, the children showed normal immunological indices: IgG level, general IgE and interleukin 4 (Il 4). in over 90% of cases, the researchers were able to avoid any surgical treatment of adenoids, by replacing it with a painless, safe and efficient, conservative method.
Key words: interleukins, Ige, procalcitonin (pct), cortisol, adenoiditis.
Key words: interleukins, Ige, procalcitonin (pct), cortisol, adenoiditis.
94-97 589
Abstract
Based on the literature, the sickness rate of urinary tract infections among children is increasing every year. Until now there has been much debate about the principles of the antirecurrent therapy and its efficiency among children, suffering from urinary infections, especially from pyelonephritis. This circum stance defines the search for the new efficient and safe treatment approaches and prevention methods of the urinary infection exacerbations. The researchers presented the results of the combined phytogenous medication application (canephron n, bionorica, germany) among 46 children with recurrent pyelonephritis. The combined phytogenous medication was prescribed within the decline period of the acute inflammatory process in conjunction with the antibacterial medicines. They noticed good tolerance of a medication. the full remission of pyelonephritis (over 6 months) was achieved among 28 (61%) children, while 15 (32%) patients showed some reduction of the relapse frequency (from 4–5 to 1–2 times a year). thus, the introduction of the combined phytogenous medication into the complex therapy of recurrent pyelonephritis among children allows us to reduce the frequency and duration of relapses, as well as to improve the disease prognosis, respectively.
Key words: urinary infections, pyelonephritis, children, phytotherapy, combined phytogenous medication.
Key words: urinary infections, pyelonephritis, children, phytotherapy, combined phytogenous medication.
FROM THE UNION OF PEDIATRICIANS OF RUSSIA
GUIDE FOR AUTHORS
IN MEMORY OF
ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)
ISSN 2500-3089 (Online)
