Влияние различных факторов на ранние этапы формирования кишечной микробиоты
https://doi.org/10.15690/pf.v13i3.1577
Аннотация
Благодаря современным молекулярно-генетическим методам исследования микробиоты идентифицированы многочисленные, ранее не изученные виды бактерий. В результате существенно изменились представления о микробиоценозе человека, в частности о микробиоте кишечника, в значительной степени определяющей здоровье человека. В последние годы описаны механизмы влияния бактерий на метагеном, эндокринную регуляцию и функцию нервной системы. Формирование кишечной микробиоты на ранних этапах зависит от таких факторов, как осложненное течение беременности, недоношенность, оперативное родоразрешение, позднее прикладывание к груди или искусственное вскармливание с рождения, антибиотикотерапия. Однако, результаты последних исследований свидетельствуют, что воздействие микробного фактора на ребенка начинается задолго до его рождения. Современная научная гипотеза о том, что ряд отклонений в течение беременности и преждевременные роды могут быть вызваны вялотекущим микробным воспалением в полости матки, также сформировалась в связи с изучением микробиоценозов плаценты и амниотических вод. В обзоре представлен анализ последних данных о влиянии как антенатальных, так и постнатальных факторов на ранние этапы формирования кишечной микробиоты у детей.
Об авторах
С. Г. МакароваРоссия
доктор медицинских наук, заведующая отделом профилактической педиатрии НЦЗД, профессор кафедры аллергологии и клинической иммунологии Первого МГМУ им. И.М. Сеченова Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, тел.: +7 (495) 967-04-20, доб. 16-03
М. И. Броева
Россия
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Рецензия
Для цитирования:
Макарова С.Г., Броева М.И. Влияние различных факторов на ранние этапы формирования кишечной микробиоты. Педиатрическая фармакология. 2016;13(3):270-282. https://doi.org/10.15690/pf.v13i3.1577
For citation:
Makarova S.G., Broeva M.I. Different Factors Influencing Early Stages of Intestine Microbiota Formation. Pediatric pharmacology. 2016;13(3):270-282. (In Russ.) https://doi.org/10.15690/pf.v13i3.1577