Vol 4, No 5 (2007)
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AN EDITORIAL ARTICLE
GENETICS IN PEDIATRICS
25-31 451
Abstract
The article is devoted to the analysis of the genetic predisposition to celiac disease. The authors studied the associations of the HLA genes and modifier genes of the immune response (interleukine 1, inter leukine 1 receptor antagonist, inter leukine 4, α-subunits of interleukine 4 receptor, receptor to D vitamin) along with predisposition to the disease, as well as the variants of its run and accompanied autoimmune diseases (autoimmune thyroiditis, insular diabetes type 1).
Key words: celiac disease, genetic predisposition, genetic analysis.
Key words: celiac disease, genetic predisposition, genetic analysis.
ORIGINAL ARTICLES
38-40 760
Abstract
Urinal system infection is one of the most frequent bacterial infection diseases in childhood. approximately 30% of children suffer from relapses of urinal infections. Optimal therapy is very important to avoid the risk of kidney cicatrisation because of urinal infection. Last years specialists pay more attention to phyto medications, since they have both a complex action and a significantly fewer side effects as compared to synthetic medications. We have studied the action of Kanefrom phytomedication upon the urinal infection processes of children. We have found a reduced frequency of relapses among children with acute pyelonephritis, who were treated with the above medication for 3 months after a course of antibiotics. Children whose therapy was terminated after a course of antibiotics.
Key words: pyelonephritis, urinal infection, prophylaxis, children, phytotherapy.
Key words: pyelonephritis, urinal infection, prophylaxis, children, phytotherapy.
41-44 1718
Abstract
Atopic dermatitis is one of the most prevalent reasons for skin lesions in the infancy. The medications of the first line therapy for this disease are topic glucocorticosteroids (TGCS). The survey has analyzed the efficiency of a new TGCS — mometazon furoat — for treating atopic dermatitis of children. The action mechanism of this medication is connected with the suppression of proinflammatory cytokinins synthesis (Il6, Il1, TNF). Mometazon furoat has clear anti inflammatory, antipruritic and anti exudative action. The treatment results proved high efficiency of the medication both for noncomplicated atopic dermatitis and for atopic dermatitis complicated with a secondary infection.
Key words: atopic dermatitis, topic glucocorticosteroids, therapy, children.
Key words: atopic dermatitis, topic glucocorticosteroids, therapy, children.
45-47 430
Abstract
The article analyzes the efficacy and safety of the vitamin and mineral complex preventive application among the children with the allergic pathology (bronchial asthma, pollinosis) during the remission.
Key words: polyvitamins, allergies, children.
Key words: polyvitamins, allergies, children.
48-52 394
Abstract
The article gives an analysis of a 5 year observation of psoriatic process among 38 children aged 7 to 17, suffering from severe psoriasis under suppressant therapy. The author concludes that the tactics of active influence on the psoriatic process for children in most cases results in an aggressive form of the disease, resistent to the applied therapy.
Key words: psoriasis, children, suppressant therapy.
Key words: psoriasis, children, suppressant therapy.
LECTURE
54-59 3416
Abstract
Every year 3 to 5 million people suffer from flu. Children are most susceptible to flu. At the moment, the main methods of flu prophylaxis and treatment are flu vaccination and antivirus medications. Of the tested anti virus medications, 3 groups are most interesting and interferon inductors, м 2=channel blockers (derivative of adamantine) and neuraminidase inhibitors. neuraminidase inhibitors are a brand new type of virus infection therapy — they selectively inhibit activity of flu virus neuraminidases, which restrains virus from getting into the cell, exit of virion from the cell before the reproduction cycle is over and new cells are affected. Oseltamivir — one of the new neuraminidase inhibitors — can be used for a safe and efficient flu treatment and prophylaxis among adults; yet recently this medication has been authorized for children over 1 year of age, basing upon the findings of randomized controlled surveys. Data shows that usage of oseltamivir reduces the period of diseases and severity of acute flu symptoms for children with no side diseases, as well as for children suffering from cardiovascular and bronchopulmonary system diseases; besides this medication reduces the risk of secondary flu complications.
Key words: neuraminidase inhibitors, oseltamivir, flu, bird flu, antivirus medications.
Key words: neuraminidase inhibitors, oseltamivir, flu, bird flu, antivirus medications.
For Pediatricians' Practice
60-63 480
Abstract
The research studied the impact of the mixture of bacteria lysates (IRS 19) on the recurrence of the acute respiratory infections among the weakened and sickly children from TB high risk group, who underwent rehabilitation at the anti TB health center. The researcher studied the tolerance to the physical loads (Shalkov test), secretory Iga concentration in the saliva, recurrence of the acute respiratory infections under supervision in catamnesis within a year. To prevent and treat bacterial nasal and respiratory infections, the authors used the mixture of bacteria lysates (Solvay pharma) along the specific chemical tuberculosis prevention. Performed complex rehabilitation increased the resistance of the children's body infected with TB mycobacteria and conduced to the increase of the normergic reactions to tuber culine. They revealed that the recurrence of the acute respiratory infections among the children, who received the mixture of bacteria lysates, made up 0,9 ± 0,2 among the children infected and 1,1 ± 0,2 non=infected with tb mycobacteria within the first 6 months of observation. In the test group, these indices came to 2,2 ± 0,3 and 2,3 ± 0,2, respectively. After they carried on the immunocorrection course, the saliva witnessed the increase of the secretory Iga concentration (among the children both infected and non infected with TB mycobacteria). performed research proves that it is clinically efficient, safe and expedient to introduce the seasonal course of the local immuno corrector — the mixture of bacteria lysates to the set of the rehabilitation actions among the children from TB high risk groups, which allows them to recommend wider application of this medication in children.
Key words: mixture of bacteria lysates, tuberculosis, prevention, children.
Key words: mixture of bacteria lysates, tuberculosis, prevention, children.
64-68 436
Abstract
The article is dedicated to the issue of curing children with obstructive form of hypertrophic cardiomyopathy. It presents a complex evaluation of adrenergic blockers influence on the clinical finding, heart rate disorder and vegetative regulation of heart rate, as well as prognosis for patients with obstructive form of the disease. Basing upon the findings, the article indicates criteria to evaluate the efficiency of curing children suffering from hypertrophic cardiomyopathy with adrenergic blockers
Key words: hypertrophic cardiomyopathy, curing, children, adrenergic blockers.
Key words: hypertrophic cardiomyopathy, curing, children, adrenergic blockers.
69-73 456
Abstract
The «Multitabs immuno kids» vitamin and mineral complex application increases the treatment efficacy, conduces to the correction of the trophologic status, maintains the endoecosystem of the macroorganism, normalizes the metabolic processes and improves the quality of the patients' live among the children with chronic gastroduodenites during recovery.
Key words: chronic gastroduodenites, vitamin and mineral complex, children.
Key words: chronic gastroduodenites, vitamin and mineral complex, children.
74-76 488
Abstract
The authors consider the issues interaction between a doctor and a child during the radionuclide study. They also give recommendations of the pediatric council under auspices of the European society of the nuclear medicine to carry on the scintigraphic studies among the children. The article high lights the basic moments as to the psychoprophylactic preparation of the children for the radionuclide study with regard to their age and character peculiarities. The researchers offer approaches to define the psychic and emotional status of the child, degree of anxiety before the study and methods to eliminate it, allowing for considerable quality improvement of the performed procedure.
Key words: children, radionuclide diagnostics, pediatric radiology, psychoprophylactic preparation.
Key words: children, radionuclide diagnostics, pediatric radiology, psychoprophylactic preparation.
Z.M. Enikeeva,
A.Sh. Khasanova,
G.F. Minibaeva,
L.R. Kalmet'eva,
S.R. Nigmatullina,
S.N. Targonsky,
S.V. Usova
78-81 450
Abstract
The article considers results of usage of interferon α against respiratory infection among 30 children with chronic glomerulonephritis. The positive effect of oral introduction of interferon α for patients, (unlike children with glomerulonephritis and respiratory infection who didn't receive such medication) developed as the absence of exacerbation: no negative dynamics were found in the urine, blood testes and immunogram.
Key words: glomerulonephritis, respiratory infection, anti-virus therapy, interferon α, children.
Key words: glomerulonephritis, respiratory infection, anti-virus therapy, interferon α, children.
82-86 430
Abstract
The article analyzes efficiency of local immunomodulator manufactured by «npo petrovax farm» for children suffering from chronic gingivitis and multiple caries with congenital and inherited somatic diseases. It evaluated the clinical effect of the medication, the biochemical and immunological parameters of saliva composition of patients who underwent the immunomodulatory therapy. Clinical manifestations of gingivitis disappeared, with the remission during 6 months of the observation. The article shows anti inflammatory, anti oxidant, membrane stabilizing action of the medication. It shows the normalization of cariesogenic products of anaerobic lactate and pyruvate glycolysis, increase of secretory iga (Siga) and lysozyme in the saliva.
Key words: children, gingivitis, immunomodulatory therapy.
Key words: children, gingivitis, immunomodulatory therapy.
VACCINATION
11-16 576
Abstract
The article is dedicated to the problem of chicken pox in Russia and across the world, its social and economic aspects. The authors provides the modern information on the existing vaccines, their comparative efficacy in different age groups of the patients, as well as the patients from the high risk groups. The researchers reviewed the contraindications and restrictions against the immunization and analyzed the data on the safety and reactogenicity of the vaccine for the chicken pox prevention.
Key words: chicken pox, vaccination, children.
Key words: chicken pox, vaccination, children.
18-22 837
Abstract
One of the most topical issues of pharmacotherapy in child age dentistry is the treatment of oral mucous tunic. The success of the treatment and prophylaxis of diseases is based on the availability of new high-active medications in market. The article analyzes the usage specificities of bacterial lysates mixes to cure acute dartrous stomatitis of children
Key words: oral mucous tunic diseases, treatment, mix of bacterial lysates, children.
Key words: oral mucous tunic diseases, treatment, mix of bacterial lysates, children.
SHORT REPORT
87-92 410
Abstract
In this section, we have published summaries of young scientists' works presented at a conference at Scientific Center for Children's Health in June 2007.
MATERIALS OF THE WORLD HEALTH ORGANIZATION
DEBATABLE ISSUES OF PHARMACOTHERAPY
32-36 823
Abstract
Congenital malformations are still the important medical and social issue. They take the second place among the reasons for the infant mortality and cause up to 18,3% of disablement cases among the children. Exogenous factors, effecting the growing fetus, are very essential along with the genetic matters among the reasons for the congenital malformations. The importance of information on the teratogenic potential of the medications is acknowledged by the doctors from various countries. The article outlines the information on entis activity — European network of teratology information services — a non profit organization, rendering consulting services to the pregnant women and medical staff, regarding the embryo and fetotoxic actions of the medications. The authors highlight the history of entis, its objectives, principles of operation and consulting algorithm and list the basic scientific publications by the entis members for the recent years. The article deals with the most obvious problems, which the organization members face, first of all — the quality of the information they receive. The authors also provide the substantiation for the necessity to develop such an information service in Russia and express hope for the successful development of the entis subsidiary they formed in Moscow.
Key words: congenital malformations, medications, pregnancy, embryotoxicity.
Key words: congenital malformations, medications, pregnancy, embryotoxicity.
ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)
ISSN 2500-3089 (Online)
