Потенциальная целиакия — современный взгляд на проблему

На сегодняшний день большой интерес исследователей сосредоточен на изучении потенциальной целиакии, которая характеризуется выявлением у пациента повышенного уровня специфических аутоантител к тканевой трансглутаминазе и эндомизию в сочетании с наличием в генотипе аллелей HLA-DQ2/DQ8, но при отсутствии или минимальных изменениях со стороны слизистой оболочки тонкой кишки. У пациентов с потенциальной целиакией могут отмечаться различные кишечные и внекишечные симптомы заболевания, или они могут иметь бессимптомное течение. Патогенетические механизмы заболевания до конца не изучены, а риски формирования характерной для целиакии атрофии ворсинок кишечника остаются неустановленными. Стратегия ведения таких пациентов в настоящее время не разработана. Эффективность безглютеновой диеты у пациентов с потенциальной целиакией, не имеющих клинических симптомов заболевания, также окончательно не установлена.

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