ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v23i3.3053ppharm-2839Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWПотенциальная целиакия — современный взгляд на проблемуPotential Celiac Disease — Modern View on the Problemhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич - доктор медицинских наук, профессор, руководитель Московского областного центра детской гастроэнтерологии и гепатологии Научно-исследовательского клинического института детства, профессор кафедры педиатрии Медицинского института Белгородского ГНИУ.

115093, Москва, ул. Большая Серпуховская, д. 62, тел.: +7 (499) 237-02-23

MD, PhD, Professor.

62, Bolshaya Serpukhovskaya Str., Moscow, 115093, +7 (499) 237-02-23

khavkin@nikid.ruhttps://orcid.org/0000-0003-1695-0978КамиловаА. Т.KamilovaAltinoy T.

Камилова Алтиной Турсунбаевна - д.м.н., профессор.

Ташкент

MD, PhD, Professor.

Tashkent

okamilova@yahoo.comhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Налетов Андрей Васильевич - д.м.н., профессор.

Донецк

MD, PhD, Professor.

Donetsk

nalyotov-a@mail.ruhttps://orcid.org/0009-0007-9973-2293БораеваТ. Т.BoraevaTatyana T.

Бораева Татьяна Темирболатовна - д.м.н., профессор.

Владикавказ

MD, PhD, Professor.

Vladikavkaz

23510krok@mail.ruhttps://orcid.org/0000-0002-3043-8674ЛошковаЕ. В.LoshkovaElena V.

Лошкова Елена Владимировна - к.м.н.

Москва, Томск

MD, PhD.

Moscow, Tomsk

loshkova@rambler.ruhttps://orcid.org/0000-0002-8753-3824ДубовикА. В.DubovickAnna V.

Дубовик Анна Владимировна - к.м.н.

Краснодар

MD, PhD.

Krasnodar

dubovyk-anna@mail.ruhttps://orcid.org/0000-0003-3364-610XЯблоковаЕ. А.YablockovaEkaterina A.

Яблокова Екатерина Александровна - к.м.н.

Москва

MD, PhD.

Moscow

yablokova_e_a@staff.sechenov.ruНаучно-исследовательский клинический институт детства; Белгородский государственный национальный исследовательский университетРоссияResearch Clinical Institute of Childhood; Belgorod State National Research UniversityRussian FederationРеспубликанский специализированный научно-практический центр педиатрииУзбекистанRepublican Specialized Scientific Practical Medical Center of PediatricsUzbekistanДонецкий государственный медицинский университет им. М. ГорькогоРоссияM. Gorky Donetsk National Medical UniversityRussian FederationСеверо-Осетинская государственная медицинская академияРоссияNorth Ossetian State Medical AcademyRussian FederationМедико-генетический научный центр им. акад. Н.П. Бочкова; Сибирский государственный медицинский университетРоссияResearch Centre for Medical Genetics; Siberian State Medical UniversityRussian FederationКубанский государственный медицинский университетРоссияKuban State Medical UniversityRussian FederationНаучно-исследовательский клинический институт детства; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияResearch Clinical Institute of Childhood; Sechenov First Moscow State Medical UniversityRussian Federation202627072026233290296Copyright © Хавкин А.И., Камилова А.Т., Налетов А.В., Бораева Т.Т., Лошкова Е.В., Дубовик А.В., Яблокова Е.А., 20262026Хавкин А.И., Камилова А.Т., Налетов А.В., Бораева Т.Т., Лошкова Е.В., Дубовик А.В., Яблокова Е.А.Khavkin A.I., Kamilova A.T., Nalyotov A.V., Boraeva T.T., Loshkova E.V., Dubovick A.V., Yablockova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2839

На сегодняшний день большой интерес исследователей сосредоточен на изучении потенциальной целиакии, которая характеризуется выявлением у пациента повышенного уровня специфических аутоантител к тканевой трансглутаминазе и эндомизию в сочетании с наличием в генотипе аллелей HLA-DQ2/DQ8, но при отсутствии или минимальных изменениях со стороны слизистой оболочки тонкой кишки. У пациентов с потенциальной целиакией могут отмечаться различные кишечные и внекишечные симптомы заболевания, или они могут иметь бессимптомное течение. Патогенетические механизмы заболевания до конца не изучены, а риски формирования характерной для целиакии атрофии ворсинок кишечника остаются неустановленными. Стратегия ведения таких пациентов в настоящее время не разработана. Эффективность безглютеновой диеты у пациентов с потенциальной целиакией, не имеющих клинических симптомов заболевания, также окончательно не установлена.

The keen researcher’s interest nowadays is focused on the study of potential celiac disease. It is characterized by increased levels of specific autoantibodies to tissue transglutaminase and endomysium and by HLA-DQ2/DQ8 alleles in the genotype with no or minimal changes in small intestine mucous membrane. Patients with potential celiac disease may have various intestinal and extraintestinal symptoms, however the disease can be asymptomatic. Disease pathogenetic mechanisms are not fully understood, and villous atrophy (typical for celiac disease) risks remain unknown. There is no management strategy for such patients. Gluten-free diet efficacy in patients with potential celiac disease, who do not have any clinical symptoms, is also not conclusively established.

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The authors declare that there are no conflicts of interest present.