Генерализованная менингококковая инфекция у новорожденного: клинический пример и обзор литературы
https://doi.org/10.15690/pf.v20i2.2544
Аннотация
Neisseria meningitidis — один из основных этиологических факторов менингита и сепсиса у детей и взрослых, но в неонатальном периоде обнаруживается редко. Клиническое распознавание неонатальной менингококковой инфекции затруднено, исход заболевания часто фатальный, в связи с чем своевременная диагностика и адекватная терапия критически важны. В статье описан новорожденный ребенок с менингококковым сепсисом, госпитализированный на 5-й день после рождения, и представлен обзор литературы от конца XIX в. и до настоящего времени.
Об авторе
И. Я. Извекова
Новосибирский государственный медицинский университет
Россия
Раскрытие интересов:
Россия
Извекова Ирина Яковлевна, доктор медицинских наук, профессор кафедры инфекционных болезней
630091, Новосибирск, ул. Красный проспект, д. 52
тел.: +7 (383) 218-19-95, +7 (913) 709-70-91
Раскрытие интересов:
Автор статьи подтвердил отсутствие конфликта интересов, о котором необходимо сообщить.
Список литературы
1. Pinner RW, Gellin BG, Bibb WF, et al. Meningococcal disease in the United States, 1986. Meningococcal Disease Study Group. J Infect Dis. 1991;164(2):368–374. doi: https://doi.org/10.1093%2Finfdis%2F164.2.368
2. Shepard CW, Rosenstein NE, Fischer M. Neonatal meningococcal disease in the United States, 1990 to 1999. Pediatr Infect Dis J. 2003;22(5):418–422. doi: https://doi.org/10.1097/01.inf.0000066876.77453.04
3. Huang HR, Chen HL, Chu SM. Clinical spectrum of meningococcal infection in infants younger than six months of age. Chang Gung Med J. 2006;29(1):107–112.
4. Kawai Y, Gosling RD, Jones V, Hosein IK. An unusual case of meningococcal meningitis complicated with subdural empyema in a 3 month old infant: a case report. Cases J. 2009;2:6335. doi: https://doi.org/10.4076/1757-1626-2-6335
5. Basani L, Aepala R. Neisseria Meningitidis Causing Multiple Cerebral Abscesses in Early Neonatal Period: Case Report and Review of Literature. J Clin Diagn Res. 2017;11(7):SD01–SD03. doi: https://doi.org/10.7860/JCDR/2017/25284.10151
6. Sherer. Ein Beitrag zur Aetologie der Leptomeningitis Purulenta Sаuglingen, Jahrsb. f. Kinderh. 1895;39:1.
7. Bruce RL. Epidemic Cerebro-Spinal Meningitis. Trans Epidemiol Soc Lond. 1899;18:53–84.
8. Wilson WJ. Bacteriology of cerebrospinal meningitis. Lancet. 1908;171(4424):1686–1687.
9. Holt LE. Observations on Three Hundred Cases of Acute Meningitis in Infancy and Childhood. Am J Dis Child. 1911;1:26.
10. Koplik H. Meningitis in the newborn and in infants under three months of age. Arch Pediatr. 1916;33(7):481–500.
11. Miller DJM. A case of meningococcal meningitis in the newborn with interesting unusual features. Arch Pediatr. 1917;34:824–826.
12. White TW. Case reports of infectious meningitis developing in babies 29 and 39-day-old respectively. Arch Pediatr. 1917;34:312–316.
13. Root JH. A case of meningococcus meningitis with obstructive hydrocephalus in the newly born. Am J Dis Child. 1921;21:500-505.
14. Barron M. Meningitis in the newborn and in early infancy. Am J Med Sci. 1918;156(3):358.
15. McLean S, Caffey JP. Endemic meningococcus meningitis, clinical manifestation in infancy and in early childhood. Am J Dis Child. 1928;35(3):357–387.
16. Brown A, Silverthrone N. Meningococcic meningitis in infancy: report of a case. JAMA. 1933;101(4):272–273.
17. Ravid JM. Meningococcic and nonmeningococcic meningitis in the new-born and yaung infants. Am J Dis Child. 1935;49(5):1282–1298. doi: https://doi.org/10.1001/archpedi.1935.01970050180020
18. Garrow DH. Neonatal meningococcosis. Postgraduate Med J. 1951;27(309):358–363. doi: https://doi.org/10.1136/pgmj.27.309.358
19. Reta MA, Zeleke TA. Neonatal bacterial meningitis in Tikur Anbessa Specialized Hospital, Ethiopia: a 10-year retrospective review. Springerplus. 2016;5(1):1971. doi: https://doi.org/10.1186/s40064-016-3668-1
20. Ahmareen O, Donnell SO, Satas S, et al. Neonatal meningococcal meningitis: case report. Arch Dis Child. 2008;93:206.
21. Jones RN, Slepack J, Eades A. Fatal Neonatal Meningococcal Meningitis: Association With Maternal Cervical-Vaginal Colonization. JAMA. 1976;236(23):2652–2653. doi: https://doi.org/10.1001/jama.1976.03270240048028
22. Heath PT, Nik Yusoff NK, Baker CJ. Neonatal meningitis. Arch Dis Child Fetal Neonatal Ed. 2003;88(3):F173–F178. doi: https://doi.org/10.1136/fn.88.3.f173
23. Granoff DM, Gilsdorf JR. Neisseria meningitidis (Meningococcus). In: Nelson Textbook of Pediatrics. Kliegman RM, Behrman RE, Jenson HB, Stanton BM, eds. 19th ed. Philadelphia, PA: Saunders; 2004. pp. 929–935.
24. Kim SA, Kim DW, Dong BQ, et al. An expanded age range for meningococcal meningitis: molecular diagnostic evidence from population-based surveillance in Asia. BMC Infect Dis. 2012;12:310. doi: https://doi.org/10.1186/1471-2334-12-310
25. Kiray Baş E, Bülbül A, Cömert S, et al. Neonatal infection with Neisseria meningitidis: analysis of a 97-year period plus case study. J Clin Microbiol. 2014;52(9):3478–3482. doi: https://doi.org/10.1128/JCM.01000-14
26. Mubashar T, Turner PC, Paul SP. Early-onset neonatal sepsis caused by Neisseria meningitidis serogroup B: case report and literature review of a 102-year period. Turk J Pediatr. 2020;62(1):125–129. doi: https://doi.org/10.24953/turkjped.2020.01.018
27. Bilal A, Taha MK, Caeymaex L, et al. Neonatal meningococcal meningitis in France from 2001 to 2013. Pediatr Infect Dis J. 2016;35:1270–1272. doi: https://doi.org/10.1097/INF.0000000000001296
28. Falcao MC, de Andrade SB, Ceccon MEJR. Neonatal sepsis and meningitis caused by Neisseria meningitidis: A case report. Rev Inst Med Trop Sao Paulo. 2007;49(3):191–194. doi: https://doi.org/10.1590%2FS0036-46652007000300010
29. Lo WT, Yuh US, Wang CC. Early onset neonatal infection with Neisseria meningitidis serogroup C: case report and literature review. Eur J Pediatr. 2003;162(11):785–787. doi: https://doi.org/10.1007/s00431-003-1307-7
30. Arya S, Nair D, Harish Chellani H, et al. Molecular evidence suggestive of intrauterine transmission of Neisseria meningitidis serogroup A from mother to infant. Pediatr Infect Dis J. 2007;2(1):45–50. doi: https://doi.org/10.1055/s-0035-1557014
31. Presa J, Serra L, Weil-Olivier C, York L. Preventing invasive meningococcal disease in early infancy. Hum Vaccin Immunother. 2022;18(5):1979846. doi: https://doi.org/10.1080/21645515.2021.1979846
32. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2017 году: государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2018. — 268 с.
33. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2018 году: государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2019. — 254 с.
34. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2019 году: государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2020. — 299 с.
35. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2020 году: государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2021. — 256 с.
36. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2021 году: государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2022. — 340 с.
37. Халиуллина С.В., Анохин В.А., Хаертынов Х.С. и др. Менингиты у детей раннего возраста. Критерии ранней диагностики // Российский вестник перинатологии и педиатрии. — 2019. — Т. 64. — № 5. — С. 183–188. — doi: https://doi.org/10.21508/1027-4065-2019-64-5-183-188
38. Мазанкова Л.Н., Тебеньков А.В., Россина А.Л. Менингококковая инфекция у детей — новые вызовы // Практика педиатра. — 2021. — № 3. — С. 25–29.
39. Brouwer MC, de Gans J, Heckenberg SG, et al. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis. 2009;9(1):31–44. doi: https://doi.org/10.1016/S1473-3099(08)70261-5
40. Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23(3):467–492. doi: https://doi.org/10.1128/CMR.00070-09
41. Stein-Zamir C, Abramson N, Zentner G, et al. Invasive meningococcal disease in children in Jerusalem. Epidemiol Infect. 2008;136(6):782–789. doi: https://doi.org/10.1017/S0950268807009259
42. Fone DL, Harries JM, Lester N, Nehaul L. Meningococcal disease and social deprivation: a small area geographical study in Gwent, UK. Epidemiol Infect. 2003;130(1):53–58. doi: https://doi.org/10.1017/s095026880200794x
43. Pereiró I, Díez-Domingo J, Segarra L, et al. Risk factors for invasive disease among children in Spain. J Infect. 2004;48(4):320–329. doi: https://doi.org/10.1016/j.jinf.2003.10.015
44. Костюкова НН, Бехало ВА, Чернышова ТФ. Менингококковая инфекция в России: прошлое и ближайшие перспективы // Эпидемиология и инфекционные болезни. Актуальные вопросы. — 2014. — № 2. — С. 73–79.
45. Wright JH, Councilman WT. Epidemic cerebro-spinal meningitis and its relation to other forms of meningitis: a report of the State board of health of Massachusetts. Boston: Wright & Potter printing Co., State printers; 1898.
46. Mallory FB, Wright JH. Epidemic Cerebro-Spinal Meningitis and its Relation to Other Forms of Meningitis. A report of the State board of health of Massachusetts. Councilman, W. T. (William Thomas), 1854–1933. Boston: Wright & Potter printing co., State printers; 1898.
47. Halperin SA, Bettinger JA, Greenwood B, et al. The changing and dynamic epidemiology of meningococcal disease. Vaccine. 2012;30(Suppl 2):B26–B36. doi: https://doi.org/10.1016/j.vaccine.2011.12.032
48. World report on the health of refugees and migrants. Geneva: World Health Organization; 2022.
49. Извекова И.Я., Самойлова Л.В., Чернышева Л.Ю. и др. Менингококковая инфекция в Новосибирске: изменение эпидемиологии и проблемы профилактики // Эпидемиология и Вакцинопрофилактика. — 2021. — Т. 20. — № 3. — С. 60–75. — doi: https://doi.org/10.31631/2073-3046-2021-20-3-60-75
50. Katier N, Traen M, De Dooy J, et al. Neonatal Purpura fulminans due to Neisseria meningitidis serogroup C infection. Eur J Ped. 2003;162(4):283–284. doi: https://doi.org/10.1007/s00431-003-1163-5
51. Gilbey T, McIver C, Brandenburg U, et al. Suspected Materno-Fetal Transmission of Neisseria meningitidis Serogroup W Clonal Complex 11 Causing Early-Onset Neonatal Sepsis. Open Forum Infect Dis. 2020;7(2):ofaa039. doi: https://doi.org/10.1093/ofid/ofaa039
52. Kurlenda J, Agata KP, Grinholc M. Neonatal intrauterine infection with Neisseria meningitidis B. Clin Pediatr. 2010;49(4):388–390. doi: https://doi.org/10.1177/0009922809352376
53. Filippakis D, Gkentzi D, Dimitriou G, Karatza A. Neonatal meningococcal disease: an update. J Matern Fetal Neonatal Med. 2022;35(21):4190–4195. doi: https://doi.org/10.1080/14767058.2020.1849092
54. Givan KF, Thomas BW, Johnston AG. Isolation of Neisseria meningitidis from the urethra, cervix, and anal canal: Further observations. Br J Vener Dis. 1977;53(2):109–112. doi: https://doi.org/10.1136/sti.53.2.109
55. Conde-Glez CJ, Calderón E. Urogenital infection due to meningococcus in men and women. Sex Transm Dis. 1991;18(2):72–75. doi: https://doi.org/10.1097/00007435-199118020-00003
56. Maini M, French P, Prince M, Bingham JS. Urethritis due to Neisseria meningitidis in a London genitourinary medicine clinic population. Int J STD AIDS. 1992;3(6):423–425. doi: https://doi.org/10.1177/095646249200300604
57. Lourenço MC, Reis RS, Andrade AC, et al. Subclinical infection of the genital tract with Neisseria meningitidis. Braz J Infect Dis. 2006;10(2):154–155. doi: https://doi.org/10.1590/s1413-86702006000200015
58. Tzeng YL, Bazan JA, Turner AN, et al. Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen. Proc Natl Acad Sci U S A. 2017;114(16):4237–4242. doi: https://doi.org/10.1073/pnas.1620971114
59. Eichberger J, Resch E, Resch B. Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers. Front Pediatr. (2022)10:840288. doi: https://doi.org/10.3389/fped.2022.840288
60. Clegg HW, Todres ID, Moylan FM, et al. Fulminant neonatal meningococcemia. Am J Dis Child. 1980;134(4):354–355. doi: https://doi.org/10.1001/archpedi.1980.04490010012004
61. Embree J, Law BJ, Williams T, Edye-Mazowita G. Early onset neonatal sepsis due to Neisseria meningitidis W135. Pediatr Infect Dis J. 1987;6(3):299–300. doi: https://doi.org/10.1097/00006454-198703000-00024
62. Falero GMP, Arroyos PA, Santillana FL, et al. Late neonatal sepsis with meningitis due to meningococcus serogroup C. An Esp Pediat. 1999;50(6):639–640.
63. Casanova-Román M, Rios J, Garcia-Del-Rio M, Martínez-Valverde A. Early onset neonatal sepsis due to Neisseria meningitidis B. Minerva Pediatr. 2000;52(11):659–660.
64. Furyk JS, Swann O, Molyneux E. Systematic review: neonatal meningitis in the developing world. Trop Med Int Health. 2011;16(6):672–679. doi: https://doi.org/10.1111/j.1365-3156.2011.02750.x
65. Barichello T, Fagundes GD, Generoso JS, et al. Pathophysiology of neonatal acute bacterial meningitis. J Med Microbiol. 2013;62(Pt 12):1781–1789. doi: https://doi.org/10.1099/jmm.0.059840-0
66. Xu M, Hu L, Huang H, et al. Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study. Front. Pediatr. 2019;7:31. doi: https://doi.org/10.3389/fped.2019.00031
67. Володин Н.Н., Дегтярев Д.Н., Байбарина Е.Н., Буслаева Г.Н. Неонатология: национальное руководство / под ред. Н.Н. Володина. — М.: ГЭОТАР-Медиа; 2019. — 896 с. [Volodin NN, Degtyarev DN, Baibarina EN, Buslaeva GN. Neonatologiya: National guidelines. Volodin NN, ed. Moscow: GEOTAR-Media; 2019. 896 p. (In Russ).]
68. Chugh K, Bhalla CK, Joshi KK. Meningococcal brain abscess and meningitis in a neonate. Pediat Infect Dis J. 1988;7(2):136–137. doi: https://doi.org/10.1097/00006454-198802000-00015
69. Kirkpatrick M, Brooker RJ, Helma PJ, Cole GF. Spinal cord dysfunction in neonatal meningococcal meningitis. Eur J Ped. 1994;153:367–368. doi: https://doi.org/10.1007/BF01956421
70. Ramsamy Y, Mahabeer Р, Archary М, et al. An unusual case of neonatal meningococcal meningitis complicated by subdural empyema and hydrocephalus. South African Journal of Child Health. 2013;7(1):35–37. doi: https://doi.org/10.7196/SAJCH.483
71. Tinsa F, Jallouli M, Ben Lassouad M, et al. Neonatal meningitis by Neisseria meningitis. Tunis Med. 2008;86(11):1014–1015.
72. Oordt-Speets AM, Bolijn R, van Hoorn RC, et al. Global etiology of bacterial meningitis: A systematic review and meta-analysis. PLoS One. 2018;13(6):e0198772. doi: https://doi.org/10.1371/journal.pone.0198772
73. Kumar D, Yadav RK, Singh DK, et al. Fulminant meningococcemia with meningococcal meningitis in the neonate: a case report. Int J Contemp Pediatr. 2014;1:190–192. doi: https://doi.org/10.5455/2349-3291.ijcp20141117
74. Smith A, Zehetner A. Early onset neonatal serogroup B meningococcal meningitis and septicaemia. J Paediatr Child Health. 2013;49(2):158. doi: https://doi.org/10.1111/jpc.12079
75. Fuentes DA, Fuhrmann FC, Santis AD. Neonatal meningococcal disease. An Pediatr (Barc). 2011;75(3):213–215. doi: https://doi.org/10.1016/j.anpedi.2011.04.010
76. Thompson MJ, Ninis N, Perera R, et al. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006;367(9508):397–403. doi: https://doi.org/10.1016/S0140-6736(06)67932-4
77. Menon K, Schlapbach L, Akech S, et al. for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine. Criteria for Pediatric Sepsis — A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce. Crit Care Med. 2022;50(1):21–36. doi: https://doi.org/10.1097/CCM.0000000000005294
78. Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):762–774. doi: https://doi.org/10.1001/jama.2016.0288
79. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. doi: https://doi.org/10.1007/s00134-021-06506-y
80. Devi U, Mahanta J. Neonatal meningitis due to Neisseria meningitidis serogroup Y. Indian Pediatr. 2014;51(9):757.
81. Спицин А.Н., Уткин Д.В., Куклев В.Е. и др. Применение MALDI масс-спектрометрии в диагностике особо опасных инфекционных болезней: современное состояние и перспективы // Проблемы особо опасных инфекций. 2014. — № 3. — С. 77–82. — doi: https://doi.org/10.21055/0370-1069-2014-3-77-82
82. Garges HP, Moody CM, Cotten PB, et al. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006;117(4):1094–1100. doi: https://doi.org/10.1542/peds.2005-1132
83. Viallon A, Bothelo-Nevers E, Zeni F. Clinical decision rules for acute bacterial meningitis: current insights. Open Access Emerg Med. 2016;8:7–16. doi: https://doi.org/10.2147/OAEM.S69975
84. Olin A, Henckel E, Chen Y, et al. Stereotypic Immune System Development in Newborn Children. Cell. 2018;174(5):1277–1292. e14. doi: https://doi.org/10.1016/j.cell.2018.06.045
85. Keij FM, Achten NB., Tramper-Stranders GA, et al. Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine. Front Pediatr. 2021;9:590969. doi: https://doi.org/10.3389/fped.2021.590969
86. Marchant A, Sadarangani M, Garand M, et al. Maternal immunisation: collaborating with mother nature. Lancet Infect Dis. 2017;17(7):e197–e208. doi: https://doi.org/10.1016/S1473-3099(17)30229-3
87. Abu Raya B, Sadarangani M. Meningococcal vaccination in pregnancy. Hum Vaccin Immunother. 2018;14(5):1188–1196. doi: https://doi.org/10.1080/21645515.2018.144544
Рецензия
Для цитирования:
Извекова И.Я. Генерализованная менингококковая инфекция у новорожденного: клинический пример и обзор литературы. Педиатрическая фармакология. 2023;20(2):141–155. https://doi.org/10.15690/pf.v20i2.2544
For citation:
Izvekova I.Y. Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review. Pediatric pharmacology. 2023;20(2):141–155. (In Russ.) https://doi.org/10.15690/pf.v20i2.2544
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