Preview

Pediatric pharmacology

Advanced search

Multidisciplinary Approach to Recurrent Upper Respiratory Tract Diseases in Children. Intermediate Study Results

https://doi.org/10.15690/pf.v19i6.2472

Abstract

The issue of recurrent upper respiratory tract diseases in children is common and relevant. Commonly this pathology is associated with other diseases that lead to the prolonged, complicated, or chronic course of the inflammatory process in the upper respiratory tract. Objective. The aim of the study is to improve management principles for children with recurrent upper respiratory tract diseases according to the developed multidisciplinary and personalized approach (modern methods of diagnosis and health monitoring) for achieving long-term remission. Methods. The study included 65 children aged from 3 to 17 years 11 months with recurrent upper respiratory tract diseases. Examination: nasal, nasopharynx and larynx endoscopy, abdominal ultrasound with aqueous-siphon test, tympanometry, and laboratory tests (complete blood count, evaluation of total and specific IgE levels, antistreptolysin O, nasopharynx and oropharynx microbiological study, enzyme-linked immunosorbent fecal analysis for Helicobacter pylori). Results. 88% of examined children showed allergic pathology according to our study results. Clinical signs of gastroesophageal reflux disease (GERD) were revealed in 30% of children with chronic oropharynx inflammation. GERD signs were revealed both via abdominal ultrasound with aqueous-siphon test and via fiberoptic laryngoscopy and later confirmed by esophagogastroscopy in 8.7% of patients. Obtained data indicates high prevalence of allergic and gastroenterological pathology in children with recurrent upper respiratory tract diseases. Conclusion. Obtained results allow us to establish scientifically multidisciplinary and personalized approach for the management of children with recurrent upper respiratory tract disease. This approach shall include key diagnostic methods required for improvement of comorbid conditions revealing, and achieving and maintaining control over the disease symptoms. The study is currently ongoing.

About the Authors

Leyla S. Namazova-Baranova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD, Professor, Academician of the RAS

eLibrary SPIN: 1312-2147

10, Fotievoi str., building 1, Moscow, 113999


Disclosure of interest:

Not declared.



Svetlana G. Gubanova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 8275-0163

Moscow


Disclosure of interest:

Not declared.



Elena A. Vishneva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD, Professor

eLibrary SPIN: 1109-2810

Moscow


Disclosure of interest:

Not declared.



Irina V. Zelenkova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 6206-6040

Moscow


Disclosure of interest:

Not declared.



Viktor A. Gankovskii
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 2745-7739

Moscow


Disclosure of interest:

Not declared.



Marina V. Egorova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 4758-1553

Moscow


Disclosure of interest:

Not declared.



Julia G. Levina
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

eLibrary SPIN: 4626-2800

Moscow


Disclosure of interest:

Not declared.



Elena V. Kaytukova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

eLibrary SPIN: 1272-7036

Moscow


Disclosure of interest:

Not declared.



Kamilla E. Efendieva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

eLibrary SPIN: 5773-3901

Moscow


Disclosure of interest:

Not declared.



References

1. Gulotta G, Iannella G, Vicini C, et al. Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art. Int J Environ Res Public Health. 2019;16(18):3235. https://doi.org/10.3390/ijerph16183235

2. Lou Z. Adenoid hypertrophy in children and allergic rhinitis. Eur Arch Otorhinolaryngol. 2018;275(3):831–832. https://doi.org/10.1007/s00405-017-4737-y

3. El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastroesophageal reflux disease: a systematic review. Gut. 2014;63(6):871–880. https://doi.org/10.1136/gutjnl-2012-304269

4. Ledford DK, Lockey RF. Asthma and comorbidities. Curr Opin Allergy Clin Immunol. 2013;13(1):78–86. https://doi.org/10.1097/ACI.0b013e32835c16b6

5. Formanek M, Zelenik K, Kominek P, Matousek P. Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using PEPTEST. Int J Pediatr Otorhinolaryngol. 2015;79(5):677–679. https://doi.org/10.1016/j.ijporl.2015.02.013

6. Orlandi RR, Kingdom TT, Hwang PH, et al. International consensus statement on allergy and rhinology: rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(Suppl 1):S22–S209. https://doi.org/10.1002/alr.21695

7. Katle EJ, Hart H, Kjaergaard T, et al. Nose-and sinus-related quality of life and GERD. Eur Arch Otorhinolaryngol. 2012;269(1):121–125. https://doi.org/10.1007/s00405-011-1675-y

8. Bohnhorst I, Jawad S, Lange B, et al. Prevalence of chronic rhinosinusitis in a population of patients with gastroesophageal reflux disease. Am J Rhinol Allergy. 2015;29(3):e70–e74. https://doi.org/10.2500/ajra.2015.29.4167

9. Rosen N, Vandenplas Y, Singendonk M, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the north American society for pediatric gastroenterology, hepatology and nutrition (NASPGHAN) and the European society for pediatric gastroenterology, hepatology and nutrition (ESPGHAN). J Pediatr Gastronetrol Nutr. 2018;66(3):516–554. https://doi.org/10.1097/MPG.0000000000001889

10. Loehrl TA, Samuels TL, Poetker DM, et al. The role of extraesophageal reflux in medically and surgically refractory rhinosinusitis. Laryngoscope. 2012;122(7):1425–1430. https://doi.org/10.1002/lary.23283

11. Wang Q, Lenham RK, Wang X, et al. A pilot study demonstrating the evidence for reflux disease in patients presenting with non-allergic rhinitis (NAR) — reflux disease in association with non-allergic rhinitis. Ann Esophagus. 2019;2:6. https://doi.org/10.21037/aoe.2019.03.02

12. Kurtaran H, Uyar ME, Kasapoglu B, et al. Role of Helicobacter Pylori in pathogenesis of upper respiratory system diseases. J Nat Med Assoc. 2008;100(10):1224–1230. https://doi.org/10.1016/s0027-9684(15)31471-1

13. Edouard S, Million M, Bachar D, et al. The nasopharyngeal microbiota in patients with viral respiratory tract infections is enriched in bacterial pathogens. Eur J Clin Microbiol Infect Dis. 2018;37(9):1725–1733. https://doi.org/10.1007/s10096-018-3305-8

14. Shargorodsky J, Bhattacharyya N. What is the role of nasal endoscopy in the diagnosis of chronic rhinosinusitis? Laryngoscope. 2013;123(1):4–6. https://doi.org/10.1002/lary.23385

15. Pau BC, Ng DK. Prevalence of otitis media with effusion in children with allergic rhinitis, a cross sectional study. Int J Pediatr Otorhinolaryngol. 2016;84:156–160. https://doi.org/10.1016/j.ijporl.2016.03.008

16. Dogru M, Kuran G, Haytoglu S, et al. Role of laryngopharyngeal reflux in the pathogenesis of otitis media with effusion. J Int Adv Otol. 2015;11(1):66–71. https://doi.org/10.5152/iao.2015.642

17. Mold JW, Fox C, Wisniewski A, et al. Implementing asthma guidelines using practice facilitation and local learning collaboratives: a randomized controlled trial. Ann Fam Med. 2014;12(3):233–240. https://doi.org/10.1370/afm.1624

18. Detskaya ul’trazvukovaya diagnostika: Textbook. Vol. 1. Gastroenterologiya. Pykov MI, Gurevich AI, Osmanov IM; Pykov MI, ed. Moscow: Publishing House Vidar; 2014. 256 p. (In Russ).

19. Ishida T, Manabe A, Yang SS, et al. Patterns of adenoid and tonsil growth in Japanese children and adolescents: A longitudinal study. Sci Rep. 2018;8(1):17088. https://doi.org/10.1038/s41598-018-35272-z

20. Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020;13(2):100080. https://doi.org/10.1016/j.waojou.2019.100080

21. Winter HS. Clinical manifestations and diagnosis of gastroesophageal reflux in children and adolescents. In: UpToDate. Available online: https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-gastroesophageal-reflux-disease-in-children-and-adolescents. Accessed on December 09, 2022.

22. Akhparov NN, Nemilova TK, Kagan AV, Suleymanova SB. Modern approaches to the diagnosis of gastroesophageal reflux disease in children. Russian Pediatric Journal. 2015;18(5):15–20. (In Russ).


Review

For citations:


Namazova-Baranova L.S., Gubanova S.G., Vishneva E.A., Zelenkova I.V., Gankovskii V.A., Egorova M.V., Levina J.G., Kaytukova E.V., Efendieva K.E. Multidisciplinary Approach to Recurrent Upper Respiratory Tract Diseases in Children. Intermediate Study Results. Pediatric pharmacology. 2022;19(6):437-447. (In Russ.) https://doi.org/10.15690/pf.v19i6.2472

Views: 427


ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)