ROLE OF STREPTOCOCCUS PNEUMONIAE IN THE STRUCTURE OF BACTERIAL INFECTIONS IN THE CHILDREN HOSPITALIZED TO INPATIENT HOSPITALS IN MOSCOW IN 2011–2012
https://doi.org/10.15690/pf.v10i5.816
Abstract
Data on the spread of Streptococcus pneumoniae serotypes in the RF are extremely limited. 3 pneumococcal conjugated vaccines are approved in
Russia; however, neither has yet been employed in the framework of the national population immunization program. At the same time, it is the data
on the serotype range of pneumococcal infections that may be considered the prognostic efficacy criterion for the national vaccination programs.
The objective of this research is identification of the circulating S. pneumoniae serotypes and spread of pneumococcal etiology infections in the structure of bacterial infections in the infants hospitalized to 5 inpatient hospital of Moscow in 2011–2012. The trial involved 864 patients in tote. Vast majority of patients (86%) had acute purulent otitis media and sinusitis. Community-acquired pneumonia was diagnosed in 9% of patients, sepsis and bacteremia — in 3.6%; purulent meningitis — 1.2% of patients. It has been revealed that S. pneumoniae is the primary pathogen in the structure of nasopharyngeal carriage in the children under 5 years of age hospitalized with acute bacterial infections, and the primary bacterial causative agent of acute otitis media at this age. Nasopharyngeal pneumococcal carriage analysis revealed the prevalent serotypes — 19F, 14, 23F, 3, 6A and B; they were present in 3/4 of all cases; 19F was the most frequent (> 20%). Diversity of the S. pneumoniae serotypes detected in middle ear liquid was less significant — 17 serotypes (in comparison with 24 serotypes in nasopharynx). The 5 prevalent serotypes were 19F, 3, 14, 23F, 6B and 19A (> 75% in tote). Detection rate of serotypes 3 and 19A in middle ear liquid significantly exceeded the detection rate of these serotypes in case of nasopharyngeal carriage. The study of invasive infections revealed serotypes 14, 23F, 3 and 15C. These data may be used as a benchmark for future monitoring and evaluation of effect of PCV vaccines on epidemiology of serotypes and antibiotic resistance of S. pneumoniae in Russia after introduction of PCV into the national vaccinal prevention calendar.
Russia; however, neither has yet been employed in the framework of the national population immunization program. At the same time, it is the data
on the serotype range of pneumococcal infections that may be considered the prognostic efficacy criterion for the national vaccination programs.
The objective of this research is identification of the circulating S. pneumoniae serotypes and spread of pneumococcal etiology infections in the structure of bacterial infections in the infants hospitalized to 5 inpatient hospital of Moscow in 2011–2012. The trial involved 864 patients in tote. Vast majority of patients (86%) had acute purulent otitis media and sinusitis. Community-acquired pneumonia was diagnosed in 9% of patients, sepsis and bacteremia — in 3.6%; purulent meningitis — 1.2% of patients. It has been revealed that S. pneumoniae is the primary pathogen in the structure of nasopharyngeal carriage in the children under 5 years of age hospitalized with acute bacterial infections, and the primary bacterial causative agent of acute otitis media at this age. Nasopharyngeal pneumococcal carriage analysis revealed the prevalent serotypes — 19F, 14, 23F, 3, 6A and B; they were present in 3/4 of all cases; 19F was the most frequent (> 20%). Diversity of the S. pneumoniae serotypes detected in middle ear liquid was less significant — 17 serotypes (in comparison with 24 serotypes in nasopharynx). The 5 prevalent serotypes were 19F, 3, 14, 23F, 6B and 19A (> 75% in tote). Detection rate of serotypes 3 and 19A in middle ear liquid significantly exceeded the detection rate of these serotypes in case of nasopharyngeal carriage. The study of invasive infections revealed serotypes 14, 23F, 3 and 15C. These data may be used as a benchmark for future monitoring and evaluation of effect of PCV vaccines on epidemiology of serotypes and antibiotic resistance of S. pneumoniae in Russia after introduction of PCV into the national vaccinal prevention calendar.
About the Authors
A. A. Baranov
First Sechenov Moscow State Medical University of the Ministry of Health of the Russian Federation
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
L. S. Namazova-Baranova
Scientific Center of Children’s Health, Moscow, Russian Federation
First Sechenov Moscow State Medical University of the Ministry of Health of the Russian Federation
Pirogov Russian National Medical Research University, Moscow
Russian Federation
Russian Federation
N. A. Mayanskiy
Scientific Center of Children’s Health, Moscow, Russian Federation
T. V. Kulichenko
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
head of the emergency pediatrics department with the anesthesiology-resuscitation group at the FSBI “SCCH”
Russian Federation
head of the emergency pediatrics department with the anesthesiology-resuscitation group at the FSBI “SCCH”
T. A. Polunina
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
A. V. Lazareva
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
N. M. Alyabyeva
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
L. K. Katosova
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
O. A. Ponomarenko
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation
Russian Federation
I. E. Koltunov
Morozovskaya Children’s Municipal Hospital № 1, Moscow, Russian Federation
Russian Federation
Russian Federation
A. M. Ivanenko
Morozovskaya Children’s Municipal Hospital № 1, Moscow, Russian Federation
E. A. Degtyaryova
Children’s Infectiousdiseases Clinical Hospital № 6 of the Moscow Public Health Department, Russian Federation
Russian Federation
Russian Federation
N. V. Kondratenko
Speranskiy Children’s Municipal Clinical Hospital № 9 of the Moscow Public Health Department, Russian Federation
A. A. Korsunsky
Детская городская клиническая больница № 9 им. Г.Н. Сперанского Департамента здравоохранения Москвы, Российская Федерация
Russian Federation
Russian Federation
K. V. Konstantinov
Filatov Children’s Municipal Clinical Hospital № 13 of the Moscow Public Health Department, Russian Federation
D. A. Tulupov
Filatov Children’s Municipal Clinical Hospital № 13 of the Moscow Public Health Department, Russian Federation
Russian Federation
Russian Federation
M. A. Lazareva
Scientific Center of Children’s Health, Moscow, Russian Federation
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Review
For citations:
Baranov A.A., Namazova-Baranova L.S., Mayanskiy N.A., Kulichenko T.V., Polunina T.A., Lazareva A.V., Alyabyeva N.M., Katosova L.K., Ponomarenko O.A., Koltunov I.E., Ivanenko A.M., Degtyaryova E.A., Kondratenko N.V., Korsunsky A.A., Konstantinov K.V., Tulupov D.A., Lazareva M.A. ROLE OF STREPTOCOCCUS PNEUMONIAE IN THE STRUCTURE OF BACTERIAL INFECTIONS IN THE CHILDREN HOSPITALIZED TO INPATIENT HOSPITALS IN MOSCOW IN 2011–2012. Pediatric pharmacology. 2013;10(5):6-12. https://doi.org/10.15690/pf.v10i5.816
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