Benzocaine-Induced Methemoglobinemia. A Clinical Case
Rustem F. Tepaev,
Vladimir A. Vishnevskiy,
Sergey A. Kuzin,
Iuliia V. Sergey,
Olga B. Gordeeva,
Anna V. Pytal,
Nikolay N. Murashkin https://doi.org/10.15690/pf.v15i5.1962
Abstract
The article describes a clinical case of the development of a severe, life-threatening methemoglobinemia in a patient with a dystrophic form of congenital epidermolysis bullosa while receiving a drug containing benzocaine. The current data on classification, pathogenesis, clinical course and methods for treating this state has been presented. Many substances and drugs that are methemoglobin formers are widespread and can cause chronic methemoglobinemia. Acute severe methemoglobinemia is accompanied by life-threatening organ disorders. In some cases, it may be difficult to diagnose methemoglobinemia due to the polymorphism of the clinical picture, the need for laboratory confirmation of the diagnosis, which may be underperformed in the absence of adequate alertness. The presented clinical case will be useful for doctors of various specialties.
Keywords
children,
methemoglobin,
benzocaine,
methylene blue,
epidermolysis bullosa,
esophageal dilatation,
intensive care
Supporting agencies: Not specified
About the Authors
Rustem F. Tepaev
National Medical Research Center for Children’s Health;
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Moscow
Russian Federation
Moscow
Vladimir A. Vishnevskiy
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Sergey A. Kuzin
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Iuliia V. Sergey
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Olga B. Gordeeva
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Anna V. Pytal
National Medical Research Center for Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
Nikolay N. Murashkin
National Medical Research Center for Children’s Health;
Sechenov First Moscow State Medical University (Sechenov University);
Central State Medical Academy of the Department of Presidential Affairs of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
References
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Review
For citations:
Tepaev R.F., Vishnevskiy V.A., Kuzin S.A., Sergey I.V., Gordeeva O.B., Pytal A.V., Murashkin N.N. Benzocaine-Induced Methemoglobinemia. A Clinical Case. Pediatric pharmacology. 2018;15(5):396-401. (In Russ.) https://doi.org/10.15690/pf.v15i5.1962
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