PAUCIARTICULAR JUVENILE ARTHRITIS WITH ANF-ASSOCIATED UVEITIS: CLINICAL OBSERVATION OF A FAMILY CASE (MOTHER AND DAUGHTER) WITH ANKYLOSING SPONDYLITIS IN OUTCOME IN THE MOTHER
https://doi.org/10.15690/pf.v11i1.894
Abstract
Pauciarticular juvenile arthritis associated with antinuclear factor and uveitis with onset at an early age has a special place in the structure of juvenile arthrites. This variant of arthritis is characterized by unpredictability of nosological outcomes and the prognosis is often associated with unfavorable uveitis course. Joint syndrome is characterized by frequent dactylites, which are usually associated with psoriatic arthritis. The article presents clinical observation of a family case (mother and daughter) of juvenile arthritis with onset at an early age, eye lesion, homogenous clinical manifestations in the onset and manifestation of severe ankylosing spondylitis in the mother 25 years into the disease. Both patients started undergoing adalimumab therapy at the same time and very effectively. Clinical observation illustrates the need in timely prescription of a pathogenetically substantiated genetically engineered biological therapy in order to prevent incapacitation of patients with juvenile arthritis regarding condition of joints and organ of vision.
About the Authors
I. P. Nikishina
Nasonova Research Institute of Rheumatology, Moscow
Russian Federation
MD, head of the pediatric rheumatic diseases laboratory with a rehabilitation group at the RAMS Nasonova Research Institute of Rheumatology
Russian Federation
MD, head of the pediatric rheumatic diseases laboratory with a rehabilitation group at the RAMS Nasonova Research Institute of Rheumatology
S. V. Arsenyeva
Nasonova Research Institute of Rheumatology, Moscow, Russian Federation
Russian Federation
Russian Federation
D. L. Alexeyev
Nasonova Research Institute of Rheumatology, Moscow, Russian Federation
Russian Federation
Russian Federation
A. V. Smirnov
Nasonova Research Institute of Rheumatology, Moscow, Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Nikishina I.P., Arsenyeva S.V., Alexeyev D.L., Smirnov A.V. PAUCIARTICULAR JUVENILE ARTHRITIS WITH ANF-ASSOCIATED UVEITIS: CLINICAL OBSERVATION OF A FAMILY CASE (MOTHER AND DAUGHTER) WITH ANKYLOSING SPONDYLITIS IN OUTCOME IN THE MOTHER. Pediatric pharmacology. 2014;11(1):44-50. https://doi.org/10.15690/pf.v11i1.894
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