ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v11i1.894ppharm-138Research ArticleРЕДКИЕ БОЛЕЗНИRARE DISEASESПАУЦИАРТИКУЛЯРНЫЙ ЮНОШЕСКИЙ АРТРИТ С АНФ-АССОЦИИРОВАННЫМ УВЕИТОМ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ СЕМЕЙНОГО СЛУЧАЯ У МАТЕРИ И ДОЧЕРИ С ИСХОДОМ В АНКИЛОЗИРУЮЩИЙ СПОНДИЛИТ У МАТЕРИPAUCIARTICULAR JUVENILE ARTHRITIS WITH ANF-ASSOCIATED UVEITIS: CLINICAL OBSERVATION OF A FAMILY CASE (MOTHER AND DAUGHTER) WITH ANKYLOSING SPONDYLITIS IN OUTCOME IN THE MOTHERНикишинаИ. П.NikishinaI. P.

кандидат медицинских наук, заведующая лабораторией ревматических заболеваний детского возрастас реабилитационной группой ФГБУ «НИИР им. В.А. Насоновой»

MD, head of the pediatric rheumatic diseases laboratory with a rehabilitation group at the RAMS Nasonova Research Institute of Rheumatology

irpetnik@yandex.ruАрсеньеваС. В.ArsenyevaS. V.АлексеевД. Л.AlexeyevD. L.СмирновА. В.SmirnovA. V.Научно-исследовательский институт ревматологии имени В.А. Насоновой, МоскваРоссияNasonova Research Institute of Rheumatology, MoscowRussian FederationНаучно-исследовательский институт ревматологии имени В.А. Насоновой, МоскваРоссияNasonova Research Institute of Rheumatology, Moscow, Russian FederationRussian Federation201415022014111Педиатрическая фармакология4450Copyright © Никишина И.П., Арсеньева С.В., Алексеев Д.Л., Смирнов А.В., 20142014Никишина И.П., Арсеньева С.В., Алексеев Д.Л., Смирнов А.В.Nikishina I.P., Arsenyeva S.V., Alexeyev D.L., Smirnov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/138

Пауциартикулярный юношеский артрит с дебютом в раннем возрасте, ассоциирующийся с наличием антинуклеарного фактора и увеитом, занимает особое место в структуре ювенильных артритов. При данном варианте нозологические исходы непредсказуемы, и прогноз обычно связывается с неблагоприятным течением увеита. К особенностям суставного синдрома относят частое развитие дактилитов, которые, как правило, ассоциируются с понятием псориатического артрита. В статье приводится клиническое наблюдение семейного случая ювенильного артрита у матери и дочери с началом в раннем возрасте, поражением глаз, однотипными клиническими проявлениями в дебюте и манифестацией тяжелого анкилозирующего спондилита у матери через 25 лет течения болезни. Обеим пациенткам одновременно начата терапия адалимумабом с высокой эффективностью. Клиническое наблюдение иллюстрирует необходимость своевременного назначения патогенетически обоснованной генно-инженерной биологической терапии для предупреждения инвалидизации больных ювенильным артритом по состоянию суставов и органа зрения.

Pauciarticular juvenile arthritis associated with antinuclear factor and uveitis with onset at an early age has a special place in the structure of juvenile arthrites. This variant of arthritis is characterized by unpredictability of nosological outcomes and the prognosis is often associated with unfavorable uveitis course. Joint syndrome is characterized by frequent dactylites, which are usually associated with psoriatic arthritis. The article presents clinical observation of a family case (mother and daughter) of juvenile arthritis with onset at an early age, eye lesion, homogenous clinical manifestations in the onset and manifestation of severe ankylosing spondylitis in the mother 25 years into the disease. Both patients started undergoing adalimumab therapy at the same time and very effectively. Clinical observation illustrates the need in timely prescription of a pathogenetically substantiated genetically engineered biological therapy in order to prevent incapacitation of patients with juvenile arthritis regarding condition of joints and organ of vision.

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The authors declare that there are no conflicts of interest present.