Vol 6, No 2 (2009)
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AN EDITORIAL ARTICLE
VACCINATION
26-30 501
Abstract
The recurrent and chronic infections are an actual problem in pediatrics. The regular use of antibiotics leads to the resistance of the oral cavity pathogens and disturbances in the normal microflora balance. Bacterial lysates are considered to be the efficient means to prevent and treat the acute and chronic respiratory diseases. The article is an executive summary of literature on the bacterial immune response modulating agents, including the description of the mechanism of action of these medications. The article provides for the information on the peculiarities of the topic bacterial lysates.
Key words: children, acute respiratory infections, chronic pharyngitis, chronic tonsillitis, stomatitis, bacterial immune response modulating agent.
Key words: children, acute respiratory infections, chronic pharyngitis, chronic tonsillitis, stomatitis, bacterial immune response modulating agent.
8-10 417
Abstract
The article is devoted to one of the serious problems of the today's medicine — pneumococcal infection. The authors show its importance for public health in terms of its influence upon infant and child mortality and in validization. They provide a comparative characteristic of pneumococcal vaccines used in the world. The article describes the efficiency and experience of immunizing children with a 7_valent conjugate pneumococcal vaccine in national programs that serve as a basis for recommendations on the prevention of pneumococcal infection given by the World Health Organization.
Key words: pneumococcal infection, 7-valent conjugate pneumococcal vaccine, national immunization programs, children.
Key words: pneumococcal infection, 7-valent conjugate pneumococcal vaccine, national immunization programs, children.
12-14 449
Abstract
Young sexually active men may have anogenital HPV related infection, which can cause the genital penis verruca, penis cancer, perianal and anal cancer. Besides, men's HPV infection may cause an infection and subsequent diseases of cervix of the uterus and other organs among women. The available opportunity to inoculate boys and young men against HPV infection provides for 100% guaranteed protection from severe diseases not only for boys and young men but also for girls and women, who men may have sexual intercourse with.
Key words: papilloma viral infection, men, prevention.
Key words: papilloma viral infection, men, prevention.
GENETICS IN PEDIATRICS
17-19 453
Abstract
It's known, nitrogen oxide takes part in formation of the allergic inflammation. One of the enzymes, which produce NO, is the neuronal NO synthase (n NOS). The research objective is to determine the value of n NOS 276С-Т gene polymorphism in formation of atopic dermatitis in children. The research incorporated 119 children aged from 1 to 18, suffering from atopic dermatitis. The author has identified that n NOS 276С-Т gene polymorphism is associated with the development of atopic dermatitis in children, as well as with the best response to the performed basic therapy. The research proved that there is no relation between n NOS 276С_Т gene polymorphism and illness severity, level of IgE in blood serum.
Key words: atopic dermatitis, children, basic therapy, neuronal NO synthase, gene polymorphism.
Key words: atopic dermatitis, children, basic therapy, neuronal NO synthase, gene polymorphism.
PHARMACOECONOMICS IN PEDIATRICS
PHARMACOECONOMIC JUSTIFICATION OF THE RATIONAL ANTIBIOTIC TREATMENT OF THE THERMAL BURNS IN CHILDREN
20-25 437
Abstract
The rational management for the treatment of the burn disease among children provides for the approach deemed to be justified both from the clinical and economic viewpoints. Considering the importance of the antibacterial component in treatment of the burns, the researchers carried out the pharmacoeconomic analysis of the actual antibiotic treatment for the thermal injuries of children, based on the data from the combustiology department of the 2nd Voronezh regional children's clinical hospital. They defined ways to optimize medical assistance to the burnt children at the hospital stage. By means of the mathematical analysis, they proved the economic efficiency of midecamycin, amikacin, gentamicin, ceftazidime and ceftriaxone application.
Key words: children, burns, antibacterial treatment, pharmacoeconomic analysis.
Key words: children, burns, antibacterial treatment, pharmacoeconomic analysis.
ORIGINAL ARTICLES
31-34 503
Abstract
The researchers examined the opportunities to use determination in the serum among children with chronic liver diseases of various etiologies of the hyaluronic acid levels, collagen type IV, matrix metalloproteinase-2, tissue inhibitor of the matrix proteinases 1 in diagnostics of the liver fibrosis degree. They have found out that children with the given pathology show significantly growing concentrations of these compounds against marked fibrotic changes in the liver parenchyma. Hyaluronic acid, collagen type IV and matrix metalloproteinase 2 may be reliable noninvasive cirrhosis markers and used to monitor the efficiency of therapy for the chronic liver diseases among children.
Key words: matrix metalloproteinase-2, tissular inhibitor of the matrix proteinases 1, liver cirrhosis, markers, diagnostics, children.
Key words: matrix metalloproteinase-2, tissular inhibitor of the matrix proteinases 1, liver cirrhosis, markers, diagnostics, children.
L.M. Ogorodova,
I.V. Shakhova,
T.A. Evdokimova,
E.V. Deeva,
L.A. Korepanova,
T.M. Ershova,
E.G. Sadovnikova,
E.V. Yarovenko,
T.G. Dammer,
E.V. Archakova,
Yu.V. Bronnikova,
I.A. Nelikhova,
N.V. Protasova
36-39 510
Abstract
The article provides the data on the implementation of Childhood Asthma Control Test in the primary care. The authors showed the attitude of children, parents and doctors towards the questionnaire. They demonstrated dynamics of control over the disease assessed in ACT points. They found out that 45% of children, who received the combined therapy, may reveal the total control over asthma. For the very first time, they highlighted information on the arising difficulties during the work with ACT at the ambulatory stage.
Key words: bronchial asthma, control, ACT.
Key words: bronchial asthma, control, ACT.
40-42 732
Abstract
This article is devoted to the study of the life quality of the children, suffering from bronchial asthma, allergic rhinitis and atopic dermatitis. The authors identified that children with atopic dermatitis have the lowest level of the life quality, while children, suffering from allergic rhinitis, have the highest values of the given property. It is typical that children and their parents evaluate the life at school extremely low against rather high figures of the physical and emotional functioning.
Key words: bronchial asthma, allergic rhinitis, atopic dermatitis, children, life quality.
Key words: bronchial asthma, allergic rhinitis, atopic dermatitis, children, life quality.
43-48 523
Abstract
The article highlights the evaluation results of the IQ indices demonstrated by the school students, who reside in the regions with different degrees of the iodine deficiency severity and iodine provided regions. The authors performed the comparative analysis of the IQ indices among children with clinically euthyroid diffusive goiter and among children with normal sizes of the thyroid gland. The research included 260 children aged from 8 to 10 from 13 regions of the Russian Federation: 130 patients with the goiter diagnosed subject to the data of the ultrasound investigation and 130 children, who have normal sizes of the thyroid gland (reference group). The comparison groups were homogenous according to the education conditions (as only children from the city comprehensive schools took part in the research). For the evaluation of the intellectual development, authors used R. Kettell's intellect test free from the cultural impact (Сulture-Fair Intelligence Test, CFIT) — CF 2А form. Despite the fact that the average IQ indices in the group of children with goiter were slightly lower than among children with normal sizes of the thyroid gland, the researchers failed to identify statistically significant differences between the average IQ indices among children in the compared groups (р > 0,05). Both in the group of children with goiter and in the reference group, the average IQ indices fell within «the low normal» (80–89 points).
Key words: iodine, hypothyroidism, IQ intellect index, children.
Key words: iodine, hypothyroidism, IQ intellect index, children.
49-52 514
Abstract
High spread of the subnormal vitamin provision of the children population leads to the increased frequency of the hypovitaminosis development. Solution to the problem is to compensate the deficiency of vitamins and microelements by prescribing corresponding combined pharmacological means. The authors show that vitamins and minerals may affect the activity and metabolism of one another by performing their specific functions. The article provides for the findings of the research, in which authors examined the interaction between each single component of the vitamin and mineral complex in the event of their simultaneously absorption.
Key words: vitamins, minerals, hypovitaminosis, treatment, children.
Key words: vitamins, minerals, hypovitaminosis, treatment, children.
53-57 479
Abstract
This article covers one of the most important spheres in medicine — transplantation of a kidney from a live relative donor. The appearance of new generation immunosuppressive medicines has made it possible to boost the survivability of both the kidney and the recipient. The present research has allowed the authors to evaluate the functional state of a kidney transplant at the use of different immuno-suppression protocols (induction therapy with alemtuzumab in the first group and with daclizumab in the second one) by means of a non invasive examination method. Moreover, the authors have defined ultrasound signs of transplant rejection depending on the type (interstitial or vascular).
Key words: kidney transplantation, transplant dysfunction, evaluation of the transplant function, immunosuppression.
Key words: kidney transplantation, transplant dysfunction, evaluation of the transplant function, immunosuppression.
LECTURE
58-66 621
Abstract
The article presents modern data on prevalence, risk factors, diagnostics and treatment of Crohn's diseases among children and teenagers. It covers the issues of nutritive support, enteral feeding, demonstrative data on induction and remission support. The article gives complete information about modern therapy approaches to refractory forms of Crohn's diseases based on a new trend of «biological therapy» — more specifically, based on infliximab.
Key words: kids, teenagers, Crohn's diseases, diagnosis, treatment.
Key words: kids, teenagers, Crohn's diseases, diagnosis, treatment.
67-71 1300
Abstract
Atopic dermatitis is characterized by the chronic recurrent course and often complicated by the consecutive infection and requires an adequate and regular external treatment. This article is devoted to the overview of the key pharmacodynamic and clinical effects of the activated zinc pyrithione for the atopic dermatitis. The activated zinc pyrithione has an expressed, antiinflammatory, proapoptogenic, antifungal and antibacterial effect, owing to which it affects all the components of the atopic dermatitis pathogenesis. The research with nessed the high efficiency and safety of this medication for atopic dermatitis in children, which allows the researchers to classify it as the efficient non steroid medications for the external treatment for the atopic dermatitis among children.
Key words: atopic dermatitis, treatment, activated zinc pyrithione, children.
Key words: atopic dermatitis, treatment, activated zinc pyrithione, children.
72-75 476
Abstract
The article highlights the treatment of the respiratory tract diseases accompanied by the development of mucostasis and dyscrinia among children. The author described the mucolytic therapy thoroughly by the original medication from the N_acetylcysteine group, which has both mucolytic and antioxidant and antiinflammatory effects. These properties are more important in the event of the chronic bronchopul-monary pathology and explain its high efficiency. Different dosage forms allow the doctor to apply a medication among patients of various age, including neonates and infants.
Key words: respiratory tract diseases, mucostasis, dyscrinia, mucolytic therapy, children.
Key words: respiratory tract diseases, mucostasis, dyscrinia, mucolytic therapy, children.
For Pediatricians' Practice
76-80 705
Abstract
Deterioration of the children's health, especially as long as they study in school is one of the key issues today. The article highlights the results of the «Healthy school» program implementation, which was developed by the «Quality of life» charity fund involving Solvay Pharma. Much attention was paid to the pharmacoepidemiological study of the digestive diseases among teenagers — conformance evaluation of the given nosology pharmacotherapy at the outpatient stage to the existing standards of the evidence based medicine. The researcher described in detail nonconformances to the generally accepted recommendations identified during the study — nonprescription and/or unjustified application of the medications. They also provided the structure of the enzymatic drugs application.
Key words: pharmacoepidemiology, gastrointestinal disturbances, pharmacotherapy, children.
Key words: pharmacoepidemiology, gastrointestinal disturbances, pharmacotherapy, children.
81-84 437
Abstract
The article is devoted to the functional disorders of the large bowel motility among children. The authors examine the reasons for the given pathology and opportunities for the lactulose application as a prebiotic within the comprehensive therapy.
Key words: constipation, treatment, prebiotics, children.
Key words: constipation, treatment, prebiotics, children.
85-89 713
Abstract
The article is devoted to an important matter of pediatrics — hypovitaminosis prevention among children. The author generally provided for the functions of vitamins in ensuring the normal vital functions of the organism, as well as described the properties of certain vitamins and microelements, their uniqueness and irreplaceability. Therefore, considering great troubles in ensuring the optimal contents of these substances in the ration, the author showed the necessity of the preventive prescription of the vitamin and mineral complexes. Besides, their application is expedient during the period of recovery from acute infectious diseases and in the comprehensive therapy of the chronic somatic diseases. The author points out to the necessity to choose the dosage form of a vitamin and mineral complex with due regard for the daily requirement for the vitamins and minerals among children from different age groups.
Key words: vitamins, microelements, hypovitaminosis, prevention, children.
Key words: vitamins, microelements, hypovitaminosis, prevention, children.
90-93 525
Abstract
Nowadays, H. pylori contamination spread among people became a pandemic, including children population. Persistence of the given infection may lead not only to marked inflammatory changes in the mucous coat of stomach and duodenum but also to metastatic processes. It is undoubtedly necessary to duly perform an adequate eradication therapy. The authors of the given study share their experience in treatment of children with chronic H. pylori associated gastroduodenitis.
Key words: H. pylori, eradication, children.
Key words: H. pylori, eradication, children.
94-98 517
Abstract
In the article, the authors highlight a frequent infant's pathology of urinary system — pyelonephritis. They provided new data on the most frequent causative agents of the illness, as well as on the factors, contributing to the development and chronization of the inflammatory process. The researchers give a detailed description of the diagnostics issues, treatment and prevention principles along with etiology and pathogenesis. The authors share their own experience in the given pathology therapy with the colleagues.
Key words: urinary system infection, pyelonephritis, etiology, pathogenesis, diagnostics, clinical course, treatment, children.
Key words: urinary system infection, pyelonephritis, etiology, pathogenesis, diagnostics, clinical course, treatment, children.
99-102 575
Abstract
Shockwave lithotripsy implemented in the clinical practices in the 1980-s drastically altered the treatment approach for the urolithiasis and took a leading place in the therapy of this disease. The key task of the distant shockwave lithotripsy is to provide for the fast, reliable, safe and noninvasive kidney and renal duct litholysis. The article highlights the outcome of the shockwave lithotripsy application on Econolith 3000 for the treatment of 27 children. The results of the performed treatment indicated the high efficiency and low invasiveness of this method to eliminate the concrements, as well as the perspective of its use, including in the infants. Shockwave lithotripsy allows the specialists to abandon the traumatic surgeries.
Key words: distant shockwave lithotripsy, urolithiasis, children.
Key words: distant shockwave lithotripsy, urolithiasis, children.
FROM THE UNION OF PEDIATRICIANS OF RUSSIA
ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)
ISSN 2500-3089 (Online)
