Vol 3, No 5 (2006)
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AN EDITORIAL ARTICLE
ORIGINAL ARTICLES
6-8 529
Abstract
Rational antibacterial therapy of patients, suffering from cystic fibrosis (CF) is one of the urgent problems in pulmonology. In recent years, there has been an increase of resistant strains of microogranisms, which contributes to advance of pulmonary tissue damage and worsens the forecast of a disease. Results of bacterial research among patients, suffering from CF, not only reflect the gravity of a pathological process, but also help the doctors choose the regime of antibacterial therapy. Cefoperazone + sulbactam is a highly active antipseudomonal medication, which is effective in treatment of children, suffering from CF.
Key words: cystic fibrosis, children, cefoperazone + sulbactam.
Key words: cystic fibrosis, children, cefoperazone + sulbactam.
9-13 1045
Abstract
The authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nitrogen oxide in respiratory condensate as a biomarker during the bronchial asthma. All the patients (n = 54) have undergone determination of the bronchial hypere activity level, nitrite level in respiratory condensate, relative number of eosinophiles of nasal secretion against the background of the anti-inflammatory basic therapy application adequate to the degree of bronchial asthma severity. the researchers have revealed that application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity led to achievement of the criteria for the control over bronchial asthma symptoms among the majority of patients already towards the end of the 12th week. Nevertheless, the accurate reduction of biomarkers of allergic inflammation was registered only in the end of the treatment period (24 weeks). Thus, the application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity is necessary within no less than 24 weeks. It helps to achieve the control over symptoms of the disease, as well as it is accompanied by the accurate reduction of biomarkers of atopic inflammation, and there? Fore, it leads to the activity reduction of the respiratory tract inflammation. Biomarkers may be used not only for the purpose to assess the inflammation of the respiratory passages, but also as a marker for the asthma therapy effectiveness, which can allow optimizing the bronchial asthma therapy among children.
Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity.
Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity.
15-16 424
Abstract
The article deals with the results of antibacterial therapy of 224 children aged between 1 and 14 years old, suffering from tick-borne borreliosis (acute period). The authors have defined that selection of a medication is dependent on the form and clinical symptoms of a disease, indicators of specific immunity and peripheral blood. For the people, suffering from non erythema form of borre liosis, it is expedient to apply therapy of the 3rd generation cephalosporins, while for the people, suffering from erythema form of borreliosis, it is expedient to apply antibiotics of the penicillin group.
Key words: children, tick borne borreliosis, treatment.
Key words: children, tick borne borreliosis, treatment.
18-21 633
Abstract
The aim of the study is to identify the significant factors for the risk of candidemia development among children, suffering from burns. The authors have conducted an analytical retrospective controlling study. It shows that statistically significant factors the risk of candidemia development among children with major heat injury (burns of III–IV degree) were the area of the full? Thickness burn over 40% (or boundless, p = 0,008); use of car bapenem class antibiotics (or 0,16 with 95% confidence interval 0,08–0,36, p = 0,023); glycopeptids (or 0,13 with 95% confidence interval 0,05–0,33, p = 0,008); mucosa colonization of the upper respiratory tracts with сandida SPP (or 0,14 with 95% confidence interval 0,06–0,32, p = 0,011). Among patients with the above listed factors for the risk of candidemia development it is necessary to conduct prophylaxis by systemic antimicotics, such as: lipid associated forms of amphotericin в and fluconasol.
Key words: children, burns, intrusive candidiasis, risk factors.
Key words: children, burns, intrusive candidiasis, risk factors.
REVIEW
22-28 399
Abstract
The literature overview is dedicated to the application experience of immune response modifiers of various classes in treatment of allergic diseases among children. the authors of the article justify the prescription of immune response modifiers by frequent inter current acute respiratory diseases and complications of allergic pathology connected therewith on one hand and by the capability of immune response modifiers to change the activity of tymphocytes and inhibit the reproduction of Ige, thus, increasing the effectiveness of therapy in treatment of allergic diseases among children on the other hand.
Key words: children, allergic diseases, respiratory infections, immunity, prevention, treatment, vaccines, immune response modifiers.
Key words: children, allergic diseases, respiratory infections, immunity, prevention, treatment, vaccines, immune response modifiers.
30-40 418
Abstract
The article deals with the recommendations based on modern literature and own experience in treatment of girls, suffering from inflammatory genital diseases of chlamydia and mycoplasmal etiology. The authors examined the prescription principles of etiological, pathogenetic and symptomatic therapy, determination of terms for the therapy, criteria of chlamydiosis and genital mycoplasmosis cure, as well as backset prevention, reinfection and complications.
Key words: chlamydiosis, genital mycoplasmoses, children, teenagers, treatment.
Key words: chlamydiosis, genital mycoplasmoses, children, teenagers, treatment.
CLINICAL RECOMMENDATIONS
DOCTOR’S MANUAL
L.S. Namazova,
V.K. Tatochenko,
S.G. Aleksina,
M.G. Galitskaya,
Z.A. Izvol'skaya,
A.G. Il'in,
V.N. Sadovnikova,
O.V. Chumakova
48-59 419
Abstract
The present textbook for the doctors highlights the latest data on the flu spread, its clinical manifestations, as well as opportunities for its prevention and treatment. The authors especially carefully described the methods of immunoprophylaxis, including specific like type. They listed all the registered vaccines and vaccines of local and foreign origin to be registered in the Russian federation, methods of their injection, probable undesirable phenomena. Specific stress was laid onto the own personal data of the authors as to application of the vaccines against the flu among both healthy children and those, who suffer from various disturbances or chronic diseases, including pernicious run. The textbook was approved at the meeting of the scientific council of the general directorate, scientific center of children's health, Russian academy of medical sciences, on September 14, 2006.
For Pediatricians' Practice
60-62 14953
Abstract
Research goal — comparative evaluation of efficiency of amoxicillin/clavulanat versus unprotected penicillins and first generation cephalosporins for treatment of children with acute community acquired pneumonia. 62 children with acute pneumonia took part in the research. The main group was comprised of 47 children aged 3–17 who received amoxicillin/clavulanat, comparison group — of 16 children who received unprotected penicillins or first generation cephalosporin. Treatment efficiency was evaluated by the main clinical symptoms changes dynamics. Amoxicillin/clavulanat clinical efficiency amounted to 87,23%. Compared to comparison group, treatment with amoxicillin /clavulanat helped to speed up reduction of inflammatory processes in lungs, prevent the need for refresher courses of treatment with antimicrobials, reduce the time of stay in hospital and total amount of received medication. Research results prove the advisability of more extensive amoxicillin/clavulanat use for treatment of patients with acute community acquired pneumonia both in hospital environment and in outpatient situations.
Key words: antimicrobials, amoxicillin/clavulanat, treatment, pneumonia, children.
Key words: antimicrobials, amoxicillin/clavulanat, treatment, pneumonia, children.
63-67 504
Abstract
The article deals with the clinical case of alprostadil application for the patient, suffering from systemic lupus erythematosus (SLE) and severe anti-phospholipid syndrome, which was complicated by the arterial thrombosis. The disease has been characterized by the high activity and aggressive run. The leading factor in the clinical picture was severe anti-phospholipid syndrome, which was complicated by the arterial thrombosis along with the growth of fore necrosis on the hand skin. The active treatment, which included synchronic therapy, glucocorticoids and medications, which improved blood circulation (pentoxifylline, dipiridamol, heparin), endovenous immunoglobulin transfusion had insufficiently reduced the activity of the disease and never inhibited thrombosis growth. The alprostadil application allowed cutting short the arterial thrombosis within the first hours and preventing growth of necrosis on the hand skin, as well as completely restoring the blood circulation in the affected parts of the hands. The findings of the clinical observation allowed the researchers to make a conclusion about effectiveness of a medication and possibility to use it among the patients, suffering from sle in children's rheumatologic practice.
Key words: systemic lupus erythematosus, alprostadil, children, treatment.
Key words: systemic lupus erythematosus, alprostadil, children, treatment.
JUBILEE
ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)
ISSN 2500-3089 (Online)
