LEUKOTRIENES AND ANTILEUKOTRIENE DRUGS IN ALLERGIC RHINITIS

Abstract

Allergic rhinitis is an allergic inflammation of the nasal mucosa due to sensitization to some inhalation allergens. There are two phases of a systemic allergic reaction depending on interaction of different cell types a biochemical mediators — the early (acute) and the late (chronic). Leukotrienes are primary mediators of the late phase of allergic inflammation. The leukotrienes are a group of derivates of arachidonic acid metabolism. Antagonists of CysLT1 include montelukast, zafirlukast and pranlukast. Recently there were some studies regarding using of antileukotriene drugs for monotherapy of allergic rhinitis. Evidence of efficacy of Montelukast is provided in more than 25 randomized researches.
Key words: allergic rhinitis, leukotrienes, antileukotriene drugs, montelukast.