MODERN APPROACHES TO THE ORGANIZATION OF TRANSLATIONAL RESEARCH
https://doi.org/10.15690/pf.v11i3.1002
Abstract
The growing distance between fundamental science and clinical medicine may bring risk of decreasing effectiveness of biomedical research. Translational research is a relatively new concept; it implies application of fundamental research results to practice (from bench to bedside) using a specific combination of research stages. As a result, it provides integrated information on safety, efficacy and effectiveness of a medical technology. However, there is no generally accepted view on aims and structure of translational research. This review presents analysis of different methodological approaches to translational research.
About the Authors
A. S. Kolbin
Pavlov First St. Petersburg State Medical University
St. Petersburg State University
Russian Federation
PhD, professor, head of the department of clinical pharmacology and evidence-based medicine of Pavlov First St. Petersburg State Medical University; professor at the department of pharmacology of the medical faculty of the St. Petersburg State University
Russian Federation
PhD, professor, head of the department of clinical pharmacology and evidence-based medicine of Pavlov First St. Petersburg State Medical University; professor at the department of pharmacology of the medical faculty of the St. Petersburg State University
R. A. Gapeshin
Saint Petersburg State University, Russian Federation
Russian Federation
Russian Federation
S. M. Malyshev
Saint Petersburg State University, Russian Federation
Russian Federation
Russian Federation
References
1. Osnovnye ponyatiya v otsenke meditsinskikh tekhnologii: metod. posobie. Pod obshch. red. A.S. Kolbina, S.K. Zyryanova, D.Yu. Belousova [The Main Terms in the Evaluation of Medical Technologies: Guidance Manual. Edited by A.S. Kolbin, S.K. Zyryanov, D.Yu. Belousov. Illustrated]. Moscow, Izdatel'stvo «OKI», 2013. 42 p.
2. Stafford R. S., Radley D. C. The underutilization of cardiac medications of proven benefit, 1990 to 2002. J. Am. Coll. Cardiol. 2003; 41: 56–61.
3. Hingwala J., Diamond J., Tangri N. et al. Underutilization of peritoneal dialysis: the role of the nephrologist's referral pattern. Nephrol. Dial. Transplant. 2013; 28 (3): 732–40.
4. Lenfant C. Clinical Research to Clinical Practice — Lost in Translation? N. Engl. J. Med. 2003; 349: 868–874.
5. Kessler R., Glasgow R. E. A proposal to speed translation of healthcare research into practice: dramatic change is needed. Am. J. Prev. Med. 2011; 40 (6): 637– 644.
6. High Level Pharmaceutical Forum. Core principles on relative effectiveness. 2008.
7. Kleijnen S., George E., Goulden S. et al. Relative Effectiveness Assessment of Pharmaceuticals: Similarities and Differences in 29 Jurisdictions. Value In Health. 2012; 15: 954–960.
8. Ipatova O.M., Medvedeva N.V., Archakova A.I., Grigor'ev A.I. Vestnik Rossiiskoi akademii meditsinskikh nauk – Annals of the Russian Academy of Medical Sciences. 2012; 6: 57–65.
9. Van der Laan A. L., Boenink M. Beyond Bench and Bedside: Disentangling the Concept of Translational Research. Health Care Anal. 2012. Available at: http://link.springer.com
10. Available at: http://www.inahta.net
11. Wagner P., Srivastava S. New paradigms in translational science research in cancer biomarkers. Translational Research. 2012; 4: 343–353.
12. Solans M., Guillamon I., Permanyer-Miralda G. et al. The impact of Spanish research on mental health: An analysis of how knowledge transfers into clinical practice through guidelines. Catalan Agency for Health Information, Assessment and Quality. 2012; 3: 35–47.
13. Di Sabatino A., Moschetta A., Conte D. et al. The impact of translational research on gastroenterology. Digestive and Liver Disease. 2014; 46 (4): 293–294.
14. Sung N. S., Crowley W. F. Jr., Genel M. et al. Central challenges facing the national clinical research enterprise. JAMA. 2003; 289: 1278–1287.
15. Wehling M. Assessing the translatability of drug projects: what needs to be scored to predict success? Nat. Rev. Drug. Discov. 2009; 8: 541–546.
16. Westfall J. M., Mold J., Fagnan L. Practice-based research — «blue highways» on the NIH roadmap. JAMA. 2007; 297: 403–6.
17. Dougherty D., Conway P. H. The «3T’s» road map to transform US health care: the «how» of high-quality care. JAMA. 2008; 299: 2319–2321.
18. Drolet B., Lorenzi N. Translational research: understanding the continuum from bench to bedside. Translational Research. 2011; 1: 1–5.
19. Khoury M. J., Gwinn M., Yoon P. W. et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genetics in Medicine. 2007; 9 (10): 665–674.
20. Spoth R., Rohrbach L., Greenberg M. et al. Addressing Core Challenges for the Next Generation of Type 2 Translation Research and Systems: The Translation Science to Population Impact (TSci Impact) Framework Springer. Prevention Science. 2013. Р. 1–33.
21. Grimshaw J., Eccles M., Lavis J. et al. Knowledge translation of research findings. Bio Med. Central Implementation Science. 2012; 7: 1–17.
22. Trochim W., Kane C., Graham M. J. et al. Evaluating translational research: a process marker model. Clin. Transl. Sci. 2011; 4 (3): 153–162.
23. Wang P., Heinssen R., Oliveri M. et al. Bridging Bench and Practice: Translational Research for Schizophrenia and Other Psychotic Disorders. Neuropsychopharmacology. 2009; 34: 204–212.
24. Lucas D., Kincl L., Bovbjerg V. et al. Application of a translational research model to assess the progress of occupational safety research in the international commercial fishing industry. Safety Science. 2014; 64: 71–81.
25. Sarkar I., Butte A., Lussier Y. et al. Translational Bioinformatics: linking Knowledge across biological and clinical realms. J. Am. Med. Inform Assoc. 2011; 18: 354–357.
26. Cimino J., Ayres E., Remennik L. et al. The National Institutes of Health’s Biomedical Translational Research Information System (BTRIS): Design, contents, functionality and experience to date. Journal of Biomedical Informatics. 2013. Available at: http://www.j-biomedinform.com
27. Fishburn C. Translational research: the changing landscape of drug discovery. Drug Discovery Today. 2012. pp. 1–8.
28. Butlet D. Translational Research: crossing the value of death. Nature. 2008; 453: 840–842.
29. Millard W. NIH’s New NCATS: Bridging the Gulf From Bench to Bedside. Annals of Emergency Medicine. 2011; 58 (20): 13–17.
30. Evans S., Scarbrough H. Supporting knowledge translation through collaborative translational research initiatives: «Bridging» versus «blurring» boundary-spanning approaches in the UK CLAHRS initiative. Social Science Medicine. 2014; 106: 119–127.
31. Shlyakhto E. V. Translyatsionnaya meditsina: ot nauki k praktike [Translational Medicine: from Theory to Practice]. II Mezhdunarodnyi internet-kongress spetsialistov po vnutrennim boleznyam.15.03.2013 (II International Internet Congress of Internal Medicine Specialists. Dated 15.03.2013).
32. Strategiya razvitiya meditsinskoi nauki do 2025 goda. Rasporyazhenie Pravitel'stva Rossiiskoi Federatsii ot 28 dekabrya 2012 g. [Strategy of Medical Science Development till 2025. Decree of the Government of the Russian Federation dated December 28, 2012].
33. Rossiisko-amerikanskii nauchnyi Forum po biomeditsinskim issledovaniyam. Otchet o 1-i ezhegodnoi konferentsii. Moskva. 16–18 noyabrya 2011 (Russian-American Scientific Forum on Biomedical Research. Summary of the 1st Annual Conference. Moscow. November 16-18, 2011).
34. Fontana J., Alexander E., Salvatore M. Translational research in infectious disease: current paradigms and challenges ahead. Translational Research. 2012; 159 (6): 430–453.
Review
For citations:
Kolbin A.S., Gapeshin R.A., Malyshev S.M. MODERN APPROACHES TO THE ORGANIZATION OF TRANSLATIONAL RESEARCH. Pediatric pharmacology. 2014;11(3):15-19. https://doi.org/10.15690/pf.v11i3.1002
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