THE ANALYSIS OF THE RESULTS OF ACUTE LYMPHOBLAST LEUKEMIA TREATMENT IN CHILDREN USING A MODIFIED PROTOCOL COALL 92 IN ST. PETERSBURG

E.G. Boichenko; M.B. Ivanovskaya; I.A. Garbuzova; M.A. Shul’gina; M.S. Livshits; T.N. Kulakova; T.A. Makarova; M.B. Belogurova; G.G. Radulesku; T.D. Viktorovich; E.D. Chavpetsova; M.M. Sokolova; Yu.S. Ogorodnikova; G.I. Uleiskaya

THE ANALYSIS OF THE RESULTS OF ACUTE LYMPHOBLAST LEUKEMIA TREATMENT IN CHILDREN USING A MODIFIED PROTOCOL COALL 92 IN ST. PETERSBURG

E.G. Boichenko, M.B. Ivanovskaya, I.A. Garbuzova, M.A. Shul’gina, M.S. Livshits, T.N. Kulakova, T.A. Makarova, M.B. Belogurova, G.G. Radulesku, T.D. Viktorovich, E.D. Chavpetsova, M.M. Sokolova, Yu.S. Ogorodnikova, G.I. Uleiskaya

Abstract

The article presents the results of the treatment of children with acute lymphoblast leukemia (all) according to the coall 92 program in St.-Petersburg from 01.01.1999 to 01.01.2005. 160 primary all patients, aged 4 months to 17 years 4 months were included in the study. International criteria were used to diagnose acute lymphoblast leukemia. A 2 years course of treatment in both risk groups included a 5,5–8 months phase of intensive chemotherapy followed by maintenance therapy. 6 years after the protocol introduction in the common group of patients the following survival rate indices were obtained: the 6 years uneventful survival rate was 63 ± 4,6%, the 6 years relapses free survival rate was 69 ± 4,7%, the 6 years general survival rate was 79 ± 3,7%.

Key words: acute lymphoblast leukemia, children, intensive chemotherapy.