PRACTICAL ASPECTS OF DEVELOPMENTAL CARE OVER NEONATES WITH NEONATAL THROMBOSES
https://doi.org/10.15690/pf.v12i1.1254
Abstract
Increase in the incidence of neonatal thromboses is associated not only with the possibility for women characterized by tendency to high thrombosis to carry pregnancy, but also with the increase in enforced use of invasive treatment methods, such as catheterization of central and peripheral veins and umbilical vessels. This article is aimed at bringing peculiarities of epidemiology, pathogenesis and diagnosis, clinical manifestations and treatment of neonatal thromboses to the attention of practicing physicians. The article present tactics of treating 4 children with thrombi of varying genesis and localization based on clinical observations. The decision to start heparin therapy is made on the individual basis depending on the child's maturity at birth, thrombus localization, presence or absence of complications and nature of the concurrent pathology. The given clinical cases informatively demonstrate reasonability of a multidisciplinary approach to diagnosing and treating patients with this pathology, the need in strict selection of doses of the used drugs and continuous monitoring of coagulogram parameters in the setting of the therapy.
About the Authors
N. A. Kharitonova
Scientific Center of Children's Health, Moscow, Russian Federation
Russian Federation
Russian Federation
I. A. Belyayeva
Scientific Center of Children's Health, Moscow, Russian Federation
Russian Federation
Russian Federation
P. V. Svirin
Morozov Municipal Pediatric Clinical Hospital of the Department of Health of Moscow, Russian Federation
Russian Federation
Russian Federation
A. N. Evdokimova
Scientific Center of Children's Health, Moscow, Russian Federation
Russian Federation
Russian Federation
References
1. Svirin P.V., Rumyantsev S.A., Larina L.E., Suvorova A.V., Zharkov A.P. Treatment of neonatal thrombosis. Neonatologiya = Neonatology. 2013; 1: 76–85.
2. Zhirkova Yu.V., Belyaeva I.A., Kucherov Yu.I. Perkutannaya kateterizatsiya tsentral'nykh ven u novorozhdennykh. Pod red. akad. RAN i RAMN A.A. Baranova [Percutaneous Central Venous Catheterization in Newborns. Ed. by Acad. of RAS and RAMS A.A. Baranov]. Moscow, Pediatr"". 2013. 30 p.
3. Nowak-Gottl U., Von Kries R., Gobel U. Neonatal syptomatic thromboembolism in Germany: two years survey. Arch Dis Child Fetal Neonatal Ed. 1997; 76: F163−167.
4. Zharkov P.A. Vliyanie nositel'stva protromboticheskikh polimorfizmov na risk razvitiya trombozov u detei. Avtoref. dis. …kand. med. nauk [Impact of Prothrombotic Polymorphisms Carrier on the Risk of Thrombosis in Children. Author’s abstract]. Moscow, 2013.
5. Schmidt B., Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics. 1995; 96: 939−934.
6. Tanke R.B., van Megen R., Daniels O. Trombus detection on central venous catheters in neonatal intensive care unit. Angiology. 1994; 45: 477–480.
7. Andrew M., Monagle P., Bgrooker L. Epidemiology of venous thromboembolic evants Thromboembolic Complication during Infancy and Childhood. Hamilton, B.C.: Decker Inc. 2000. 125 р.
8. deVeber G., Andrew M. et al. Cerebral sin venous thrombosis in children. N Engl J Med. 2001; 345: 417−423.
9. deVeber G. The Canadian Pedietric Ischemic Stroke Study Group. Canadian pediatric ischemic stroke register: analysis of children with arterial ischemic stroke. Ann Neurol. 2000; 48: 526.
10. Barkagan L.Z. Narushenie gemostaza u detei [Violation of Hemostasis in Children]. Moscow, Meditsina, 1993. 176 p.
11. Chuchin M.Yu. Cerebral sinus thrombosis in childhood. Pediatriya = Pediatrics. 2005; 2: 63−70.
12. Veldman A., Nord M.F., Michel-Behnke I. Thrombosis in the critically ill neonate: incidence, diagnosis, and management. Vask Health Risk Manag. 2008; 4 (6): 1337−1348.
13. Carvalho K.S., Bodensteiner J.B., Connoly P.J., Garg B.P. Cerebral venous thrombosis in children. J Child Neurol. 2001; 16: 574–580.
14. Carvalho K.S., Gard B.R. Cerebral venous thrombosis and venous malformations in children. Neurol Clin. 2002; 20: 1061−1077.
15. Roy M., Turner- Gomes S., Gill G. et al. Accuracy of Doppler echocardiography for the diagnosis of thrombosis of thrombosis associated with umbilical venosis catheters. J Pediatr. 2002; 140: 131−134.
16. Monagle P., Chan A., Goldenberg N.A. et al. Antithrombotic Therapy in Neonates and Children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 41: 737S−801S.
17. Monagle P., Chan A., Massicotte P., Chalmers E., Michelson A.D. Antithrombotic Therapy in Children. Chest. 2004; 126 (3 Suppl.): 645S–687S.
18. Zharkov P.A. Influence of polymorphisms of genes carrier clotting and metabolism of folate on the risk of thrombosis in adults and children. Voprosy prakticheskoi pediatrii = Problems of practical pediatrics. 2012; 5: 26−32.
Review
For citations:
Kharitonova N.A., Belyayeva I.A., Svirin P.V., Evdokimova A.N. PRACTICAL ASPECTS OF DEVELOPMENTAL CARE OVER NEONATES WITH NEONATAL THROMBOSES. Pediatric pharmacology. 2015;12(1):92-96. https://doi.org/10.15690/pf.v12i1.1254
Views:
745
Email this article 