ATOPIC DERMATITIS IN CHILDREN AND ANTIBODIES TO STAHPYLOCOCCUS AUREUS SUPERANTIGENS: A COMPARISON WITH SUSCEPTIBILITY TO ANTIBIOTICS
https://doi.org/10.15690/pf.v9i3.325
Abstract
Background. Staphylococcus aureus function in atopic dermatitis (AD) children skin is double-handed: an infectious trigger and an allergen. The aim of the study was to evaluate the frequency of S. aureus enterotoxins the IgE in children with infected AD skin and to compare the IgE levels with antibiotic resistance of S. aureus. Methods: specific IgE to S. aureus enterotoxins A and B (ImmunoCap, Phadia AB, Sweden) were detected in the serum of 90 children infected with AD. The IgE levels were compared with the resistance to antibiotics (McNemar test and 95% confidential intervals of related frequencies). Results: specific IgE > 0,35 kUA/l to S. aureus enterotoxin A were found with a frequency of 0,29; to enterotoxin B — 0,36; to at least one of them — 0,43. The number of children with IgE > 0,35 kUA/l and S. aureus resistant to antibiotics was about 1/3 of the number of children with IgE < 0,35 kUA/l and S. aureus sensitive to antibiotics (р < 0,001). S. aureus in children with IgE > 0,35 kUA/l remained sensitive to oxacillin. Conclusion. In children infected with AD S. aureus enterotoxins A or/and B are revealed in 25–50% of cases. Specific IgE levels to S. aureus enterotoxins are similar in antibiotic resistant and antibiotic sensitive S. aureus skin swabs — about 30%. The IgE level to enterotoxins of S. aureus and its antibiotic resistance don't seem to be conditioned by each other.
About the Authors
M. S. Treneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
Russian Federation
Russian Federation
A. N. Pampura
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
Russian Federation
Russian Federation
T. S. Okuneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
Russian Federation
Russian Federation
References
1. Leuden J. J., Marples R. R., Kligman A. M. Staphylococcus aureus in the lesions of atopic dermatitis. Br. J. Dermatol. 1974; 90: 525–530.
2. Hauser C., Prins C., Lacour M. The role of infection agents in atopic dermatitis. In: Leung D. Y. M., ed. Atopic dermatitis: from pathogenesis to treatment. Ney York: Chapman & Hall. 1996: 67–112.
3. Елисютина О. Г., Феденко Е. С. Роль Staphylococcus aureus в патогенезе атопического дерматита. Российский аллергологический журнал. 2004; 1: 17–22.
4. Hauk P. J., Leung D. Y. Takrolimus (FK506): new treatment approach in superantigen-associated diseases like atopic dermatitis? J. Allergy Clin. Immunol. 2001; 107: 391–392.
5. Воронина В. Р., Феденко Е. С., Пампура А. Н. Влияние колонизации кожи стафилококком и выделяемых им суперантигенов на течение атопического дерматита у детей. Российский аллергологический журнал. 2004; 3: 36–42.
6. Bunikowski R., Mielke M., Skarabis H. et al. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus derived superantigens SEA and SEB in children with atopic dermatitis. J. Allergy Clin. Immunol. 1999; 103: 119–124.
7. Nomura I., Tanaka K., Tomita H. et al. Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. J. Allergy Clin. Immunol. 1999; 104: 441–446.
8. Gong J. Q., Line L., Line T. et al. Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial. Br. J. Dermatol. 2006; 155 (4): 680–687.
9. Schuttelaar M. L., Coenraads P. J. A randomized, doubleblind study to assess the efficacy of addition of tetracycline to triamcinolone acetonide in the treatment of moderate to severe atopic dermatitis. J. Eu.r Acad. Dermatol. Venereol. 2008; 22 (9): 1076–1082.
10. Herbert S., Barry P., Novick R. P. Subinhibitory clindamycin differencially inhibits transcription of exoprotein genes in Staphylococcus aureus. Infect. Immun. 2001; 69: 2996–3003.
11. Тренева М. С., Пампура А. Н., Феденко Е. С. и др. Атопический дерматит у детей: антибиотикорезистентность золотистого стафилококка в 2002–2004 и 2007–2009 годах. Российский вестник перинатологии и педиатрии. 2011; 6: 98–101.
Review
For citations:
Treneva M.S., Pampura A.N., Okuneva T.S. ATOPIC DERMATITIS IN CHILDREN AND ANTIBODIES TO STAHPYLOCOCCUS AUREUS SUPERANTIGENS: A COMPARISON WITH SUSCEPTIBILITY TO ANTIBIOTICS. Pediatric pharmacology. 2012;9(3):68-71. (In Russ.) https://doi.org/10.15690/pf.v9i3.325
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