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N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN DIAGNOSTICS OF NON-COMPACTED MYOCARDIUM IN CHILDREN

https://doi.org/10.15690/pf.v9i5.457

Abstract

Non-compacted myocardium is a rare congenital cardiomyopathy. Due to the lack of uniform criteria, diagnostics of this condition is complicated presently, which results in over-diagnosing. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of chronic cardiac insufficiency (CCI) in children. The results of the study of NT-proBNP in non-compacted myocardium diagnostics are represented in this article. It was established, that serum NT-proBNP levels were higher in children with non-compacted myocardium than in children with CCI and without this disorder (р < 0,01). The received data can be useful in clinical practice.

About the Authors

E. N. Arkhipova
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


I. V. Sil’nova
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


E. N. Basargina
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


I. V. Dvoryakovskii
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


A. B. Sugak
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


N. A. Mayanskii
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


M. K. Umarova
Scientific Center of Children’s Health of RAMS, Moscow, Russian Federation
Russian Federation


References

1. Sanchez-Quintana D., Garcia-Martinez V., Climent V., Hurle J. M. Morphological changes in the normal pattern of ventricular myoarchitecture in the developing human heart. Anat. Rec. 1995; 243: 483–495.

2. Sedmera D., Pexieder T., Vuillemin M. et al. Developmental patterning of the myocardium. Anat. Rec. 2000; 258: 319–337. 3. Srivastava D., Olson E. N. A genetic blueprint for cardiac development. Nature. 2000; 407: 221–226.

3. Nugent A. W., Daubeney P. E., Chondros P. et al. National Australian childhood cardiomyopathy study: the epidemiology of childhood cardiomyopathy in Australia. N Engl J Med. 2003; 348: 1639–1646.

4. Sasse-Klaassen S., Gerull B., Oechslin E. et al. Isolated noncompaction of the left ventricular myocardium in the adult is an autosomal dominant disorder in the majority of patients. Am J Med Genet. 2003; 119A: 162–167.

5. Junga G., Kneifel S., Von Smekal A. et al. Myocardial ischaemia in children with isolated ventricular non-compaction. Eur Heart J. 1999; 20 (12): 910–916.

6. Jenni R., Wyss C., Oechslin E., Kaufmann P. Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol. 2002; 39: 450–454.

7. Alsaileek A. A., Syed I., Seward J. B., Julsrud P. Myocardial fibrosis of left ventricle: magnetic resonance imaging in noncompaction. J Magn Reson Imaging. 2008; 27 (3): 621–624.

8. Finsterer J., Stollberger C., Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.

9. Freedom R., Yoo S-J., Perrin D. et al. The morphological spectrum of ventricular noncompaction. Cardiol Young. 2005; 15: 345–364.

10. Ross R. Grading the severity of congestive heart failure in infants. Pediatr Cardiol. 1992; 13: 72–75.

11. Toyono M., Kondo C., Nakajima Y. et al. Effects of carvedilol on left ventricular function, mass, and scintigraphic findings in isolated left ventricular non-compaction. Heart. 2001; 86: 4–6.

12. Braunwald E. The management of heart failure: the past, the present, and the future. Circ Heart Fail. 2008; 1: 58–62.

13. Katz A. M. Heart failure: pathophysiology, molecular biology, and clinical management. Philadelphia: Lippincott Williams & Wilkins. 2000.

14. Konstam M. A. «Systolic and diastolic dysfunction» in heart failure? Time for a new paradigm. J Card Fail. 2003; 9: 1–3.

15. Packer M. How should physician view heart failure? The philosophical and physiological evolution of three conceptual models of the disease. Am J Cardiol. 1993; 71: 3–11.

16. Nakao K., Itoh H., Saito Y. et al. The natriuretic peptide family. Curr Opin Nephrol Hypertens. 1996; 5: 4–11.

17. Levin E. R., Gardner D. G., Samson W. K. Natriuretic peptides. N Engl J Med. 1998; 339: 321–328.

18. Johns M. C., Stephenson C. Amino-terminal pro-B-type natriuretic peptide testing in neonatal and pediatric patients. Am J Cardiol. 2008; 101: 76–81.

19. Davis G. K., Bamforth F., Sarpal A. B-type natriuretic peptide in pediatrics. Clin Biochem. 2006; 39: 600–605.

20. Mir T. S., Marohn S., Laer S. et al. Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure. Pediatrics. 2002; 110 (6): 76.

21. Bolger A. P., Sharma R., Li W. et al. Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation. 2002; 106: 92–99.

22. Ohuchi H., Ohashi H., Park J. et al. Abnormal postexercise cardio: vascular recovery and its determinants in patients after right ventricular outflow tract reconstruction. Circulation. 2002; 106: 2819–2826.

23. Price J. F., Thomas A. K., Grenier M. et al. B-type natriuretic peptide predicts adverse cardiovascular events in pediatric outpatients with chronic left ventricular systolic dysfunction. Circulation. 2006; 114: 1063–1069.

24. Архипова Е. Н., Родионова Т. В., Басаргина Е. Н., Маянский Н. А. Закономерности изменения содержания NT-proBNP в крови и их диагностическая значимость у детей с хронической сердечной недостаточностью. Лабораторная диагностика в педиатрии. 2012; 4 (3): 11–16.


Review

For citations:


Arkhipova E.N., Sil’nova I.V., Basargina E.N., Dvoryakovskii I.V., Sugak A.B., Mayanskii N.A., Umarova M.K. N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN DIAGNOSTICS OF NON-COMPACTED MYOCARDIUM IN CHILDREN. Pediatric pharmacology. 2012;9(5):65-69. (In Russ.) https://doi.org/10.15690/pf.v9i5.457

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