ALLOTRANSPLANTATION OF ABO-INCOMPATIBLE KIDNEYS IN CHILDREN
https://doi.org/10.15690/pf.v9i5.456
Abstract
At present the problem of donor organs for transplantation shortage remains unsolved. Cautious and mixed attitude towards the transplantation of incompatible kidneys remains, while it could considerably reduce the donor organ waiting time for a recipient. Experience of 19 allotransplantations of ABO-incompatible kidneys in children is analyzed in the article. A group of 14 patients who received ABOcompatible kidneys was chosen for the comparative analysis. Such parameters as the assessment of function of allotransplanted kidneys, morphology character comparison of biopsy materials of allo-kidneys in both groups, actuarial survival rate of the recipients with functioning allografts are used to assess the results. Comparison of the aforementioned parameters showed practically the same results, and that enables us to assert that transplantations of kidneys of ABO-incompatible donors have the right to exist.
About the Authors
V. A. Goryaynov
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
M. M. Kaabak
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
N. N. Babenko
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
L. A. Shishlo
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
M. M. Morozova
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
A. A. Ragimov
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
N. G. Dashkova
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
E. L. Salimov
Petrovskiy Russian Scientific Center of Surgery, Moscow, RAMS, Russian Federation
Russian Federation
Russian Federation
References
1. Hume D. M., Merrill J. P., Miller D. E., Thorn G. W. Experience with renal homotransplantations in the human: report of nine cases. J Clin Invest. 1955; 34: 327–382.
2. Starzl T. E., Marchioro T. L., Holmes J. H., Hermann G., Brittain R. S., Waddell W. R. Renal homografts in patients with major donor-recipient blood-group incompatibilities. Surgery. 1964; 55: 195–200.
3. Colvin R. B., Smith R. N. Antibody-mediated organ-allograft rejection. Nat Rev Immunol. 2005; 5: 807–817.
4. Slapak M., Neil R. B., Lee H. A. Renal transplant in a patient with major donor-recipient blood-group incompatibility: reversal of acute rejection by the use of modified plasmapheresis. Transplantation. 1981; 31: 4–7.
5. Gloor J. M., Stegal M. D. ABO-incompatible kidney reansplantation. Curr Opin Hephrol Hypertens. 2007; 16 (6): 529–534.
6. Crew Russell J., Ratner Lloyd E. ABO-incompatible kidney transplantation: current practice and the decade ahead. Current Opinion in Organ Transplantation. 2010; 15 (4): 526–530.
7. Arias M., Lypez-Hoyos M. ABO-incompatible living-donor kidney transplantation. Nephrologia. 2010; 30 (1): 10–14.
8. Flint S. M., Walker R. G., Hogan C., Haeusler M. N., Robertson A., Francis D. M., Finlay M., Landgren A., Cohney S. J. Successful ABOincompatible kidney transplantation with antibody removal and standard immunosuppression. Amer J Transplant. 2011; 11 (5): 1016–1024.
9. Warner P. R., Nester T. A. ABO-incompatible solid-organ transplantation. Amer J Clin Pathol. 2006; 125 (Suppl. 1): 87–94.
Review
For citations:
Goryaynov V.A., Kaabak M.M., Babenko N.N., Shishlo L.A., Morozova M.M., Ragimov A.A., Dashkova N.G., Salimov E.L. ALLOTRANSPLANTATION OF ABO-INCOMPATIBLE KIDNEYS IN CHILDREN. Pediatric pharmacology. 2012;9(5):59-64. (In Russ.) https://doi.org/10.15690/pf.v9i5.456
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