Modern Approaches to the Diagnosis, Treatment and Prevention of Arterial Hypertension in Children
https://doi.org/10.15690/pf.v23i1.3005
Abstract
In recent decades, arterial hypertension (AH) in children has acquired the status of a significant global health problem, with its prevalence steadily increasing. Early detection and accurate diagnosis are crucial, as elevated blood pressure (BP) in childhood is closely linked to the risk of cardiovascular, renal, and neurological complications in adulthood. A significant step forward has been the introduction of ambulatory blood pressure monitoring (ABPM), which allows for identification of white-coat and masked hypertension, as well as more accurate patient stratification. Etiologically, AH in children is divided into primary and secondary forms. The primary form is more often associated with obesity, genetic predisposition, low physical activity and high sodium intake. Secondary form is often caused by kidney, cardiovascular and endocrine disorders. It should be emphasized that hypertension is often asymptomatic in childhood, highlighting the need for regular screening starting at 3 years of age, and even earlier for children at risk. Management is based on a stepwise approach. Non-drug measures are of primary importance — dietary correction, increased physical activity, and normalization of body weight. If these measures are insufficiently effective, pharmacotherapy with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, or thiazide diuretics is prescribed, with individualization of target BP levels depending on age and comorbidities. Given the limited data on the long-term safety of antihypertensive drugs in pediatrics, prevention and early lifestyle modification remain priority areas.
Keywords
About the Authors
D. Yu. VasilyevaRussian Federation
Darya Yu. Vasilyeva - student.
117513, 1 Ostrovityanova Str., building 6, Moscow, 117513; +7 (920) 070-70-47
Disclosure of interest:
Not declared
N. A. Andrianov
Russian Federation
Nikolay A. Andrianov - student.
Smolensk
Disclosure of interest:
Not declared
A. V. Goncharova
Russian Federation
Anastasia V. Goncharova - graduate.
Smolensk
Disclosure of interest:
Not declared
A. I. Klak
Russian Federation
Anastasia I. Klak - student.
Ivanovo
Disclosure of interest:
Not declared
A. I. Minnekhanova
Russian Federation
Aigul I. Minnekhanova, student.
Kazan
Disclosure of interest:
Not declared
J. G. Adzhakavova
Russian Federation
Jennet G. Adzhakavova - student.
Saint Petersburg
Disclosure of interest:
Not declared
Yu. A. Zakharova
Russian Federation
Yulia A. Zakharova - student.
Moscow
Disclosure of interest:
Not declared
E. I. Emelianenko
Russian Federation
Ekaterina I. Emelianenko - student.
Moscow
Disclosure of interest:
Not declared
M. E. Lubenets
Russian Federation
Maria E. Lubenets – student.
Rostov-on-Don
Disclosure of interest:
Not declared
V. V. Laputko
Russian Federation
Victoria V. Laputko - student.
Tomsk
Disclosure of interest:
Not declared
D. D. Abdullina
Russian Federation
Diana D. Abdullina – student.
Kazan
Disclosure of interest:
Not declared
E. R. Yakupova
Russian Federation
Elza R. Yakupova - student.
Samara
Disclosure of interest:
Not declared
E. S. Arustamova
Russian Federation
Elizaveta S. Arustamova - student.
Saint Petersburg
Disclosure of interest:
Not declared
References
1. Blumenthal S, Epps RP, Heavenrich R, et al. Report of the task force on blood pressure control in children. Pediatrics. 1977; 59(5 2 suppl):I–II, 797–820.
2. Pac M, Obrycki Ł, Koziej J, et al. Assessment of hypertensionmediated organ damage in children and adolescents with hypertension. Blood Press. 2023;32(1):2212085. doi: https://doi.org/10.1080/08037051.2023.2212085
3. Flynn JT, Kaelber DC, Baker-Smith CM, et al. Subcommittee on screening and management of high blood pressure in children. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics. 2017;140(3):e20171904. doi: https://doi.org/10.1542/peds.2017-1904
4. Rabi DM, McBrien KA, Sapir-Pichhadze R, et al. Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2020;36(5):596–624. doi: https://doi.org/10.1016/j.cjca.2020.02.086
5. Lurbe E, Agabiti-Rosei E, Cruickshank JK, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016;34(10):1887–1920. doi: https://doi.org/10.1097/HJH.0000000000001039
6. Aleksandrov AA, Kisliak OA, Leontyeva IV. Clinical guidelines on arterial hypertension diagnosis, treatment and prevention in children and adolescents. Systemic Hypertension. 2020;17(2):7–35. (In Russ). doi: https://doi.org/10.26442/2075082X.2020.2.200126
7. Blanchette E, Flynn JT. Implications of the 2017 AAP Clinical Practice Guidelines for Management of Hypertension in Children and Adolescents: a Review. Curr Hypertens Rep. 2019;21(5):35. doi: https://doi.org/10.1007/s11906-019-0943-x
8. Karam S, Cohen DL, Jaoude PA, et al. Approach to Diagnosis and Management of Hypertension: A Comprehensive and Combined Pediatric and Adult Perspective. Semin Nephrol. 2023;43(4):151438. doi: https://doi.org/10.1016/j.semnephrol.2023.151438
9. Burlutskaya AV, Korobkina OG. Predictors of arterial hypertension in children (A Review). Kuban Scientific Medical Bulletin. 2020;27(6):123–135. (In Russ). doi: https://doi.org/10.25207/1608-6228-2020-27-6-123-135]
10. Sharma AK, Metzger DL, Rodd CJ. Prevalence and Severity of High Blood Pressure Among Children Based on the 2017 American Academy of Pediatrics Guidelines. JAMA Pediatr. 2018;172(6):557–565. doi: https://doi.org/10.1001/jamapediatrics.2018.0223
11. Umano GR, Cirillo G, Rondinelli G, et al. LSS rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity. Genes (Basel). 2023;14(8):1618. doi: https://doi.org/10.3390/genes14081618
12. Pickering TG, Hall JE, Appel LJ, et al. Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Circulation. 2005;111(5):697–716. doi: https://doi.org/10.1161/01.CIR.0000154900.76284.F6
13. Ashraf M, Irshad M, Parry NA. Pediatric hypertension: an updated review. Clin Hypertens. 2020;26(1):22. doi: https://doi.org/10.1186/s40885-020-00156-w
14. Stabouli S, Chainoglou A, Evripidou K, et al. Comparison of validation protocols for blood pressure measuring devices in children and adolescents. Front Cardiovasc Med. 2022;9:1001878. doi: https://doi.org/10.3389/fcvm.2022.1001878
15. Basalely A, Hill-Horowitz T, Sethna CB. Ambulatory Blood Pressure Monitoring in Pediatrics, an Update on Interpretation and Classification of Hypertension Phenotypes. Curr Hypertens Rep. 2023;25(1):1–11. doi: https://doi.org/10.1007/s11906-022-01231-3
16. Agapitov LI, Cherepnina IV. Diagnostics and treatment of arterial hypertension in children and adolescents, overview of new clinical guidelines of the American Academy of Pediatrics. Rossiyskiy Vestnik Perinatologii i Pediatrii = Russian Bulletin of Perinatology and Pediatrics. 2019;64(4):114–127. (In Russ). doi: https://doi.org/10.21508/1027-4065-2019-64-4-114-127
17. Fox C. Pediatric Hypertension. Prim Care. 2021;48(3):367–378. doi: https://doi.org/10.1016/j.pop.2021.04.001
18. Bassareo PP, Calcaterra G, Sabatino J, et al. Primary and secondary paediatric hypertension. J Cardiovasc Med (Hagerstown). 2023;24(1):e77–e85. doi: https://doi.org/10.2459/JCM.0000000000001432
19. Mancia G, Kreutz R, Brunström M, et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41(12):1874–2071. doi: https://doi.org/10.1097/HJH.0000000000003480
20. Falkner B, Gidding SS, Baker-Smith CM, et al. Pediatric Primary Hypertension: An Underrecognized Condition: A Scientific Statement From the American Heart Association. Hypertension. 2023;80(6):e101– e111. doi: https://doi.org/10.1161/HYP.0000000000000228
21. Sawyer A, Zeitler E, Trachtman H, Bjornstad P. Kidney Considerations in Pediatric Obesity. Curr Obes Rep. 2023;12(3):332–344. doi: https://doi.org/10.1007/s13679-023-00522-3
22. Urbina EM, Lande MB, Hooper SR, Daniels SR. Target Organ Abnormalities in Pediatric Hypertension. J Pediatr. 2018;202:14–22. doi: https://doi.org/10.1016/j.jpeds.2018.07.026.
23. Patel N, Walker N. Clinical assessment of hypertension in children. Clin Hypertens. 2016;22:15. doi: https://doi.org/10.1186/s40885-016-0050-0
24. Tullus K, Brennan E, Hamilton G, et al. Renovascular hypertension in children. Lancet. 2008;371(9622):1453–1463. doi: https://doi.org/10.1016/S0140-6736(08)60626-1
25. Vo NJ, Hammelman BD, Racadio JM, et al. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006;36(10):1032–1036. doi: https://doi.org/10.1007/s00247-006-0253-8
26. Vasbinder GB, Nelemans PJ, Kessels AG, et al. Diagnostic tests for renal artery stenosis in patients suspected of having renovascular hypertension: a meta-analysis. Ann Intern Med. 2001;135(6):401–411. doi: https://doi.org/10.7326/0003-4819-135-6-200109180-00009
27. Nam HH, Jang DK, Cho BR. Complications and risk factors after digital subtraction angiography: 1-year single-center study. J Cerebrovasc Endovasc Neurosurg. 2022;24(4):335–340. doi: https://doi.org/10.7461/jcen.2022.E2022.05.001
28. Mitsnefes MM, Wühl E. Role of hypertension in progression of pediatric CKD. Pediatr Nephrol. 2023;38(11):3519–3528. doi: https://doi.org/10.1007/s00467-023-05894-1
29. Boriskov MV, Petshakovskiĭ PIu, Serova TV, Karakhalis NB. Aortic coarctation in newborn. Pirogov Russian Journal of Surgery. 2010;(10):89–94. (In Russ).
30. Salciccioli KB, Zachariah JP. Coarctation of the Aorta: Modern Paradigms Across the Lifespan. Hypertension. 2023;80(10):1970– 1979. doi: https://doi.org/10.1161/HYPERTENSIONAHA.123.19454
31. Rodrigues JCL, Jaring MFR, Werndle MC, et al. Repaired coarctation of the aorta, persistent arterial hypertension and the selfish brain. J Cardiovasc Magn Reson. 2019;21(1):68. doi: https://doi.org/10.1186/s12968-019-0578-8
32. Kaya U, Colak A, Becit N, et al. Surgical Management of Aortic Coarctation from Infant to Adult. Eurasian J Med. 2018;50(1):14–18. doi: https://doi.org/10.5152/eurasianjmed.2017.17273
33. Conti L, Borg Savona S, Spiteri T, et al. Aortic coarctation — never too late to diagnose, never too late to treat. Images Paediatr Cardiol. 2017;19(3):1–11.
34. Cioana M, Deng J, Hou M, et al. Prevalence of Hypertension and Albuminuria in Pediatric Type 2 Diabetes: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(4):e216069. doi: https://doi.org/10.1001/jamanetworkopen.2021.6069
35. Raina R, Krishnappa V, Das A, et al. Overview of Monogenic or Mendelian Forms of Hypertension. Front Pediatr. 2019;7:263. doi: https://doi.org/10.3389/fped.2019.00263
36. Göknar N, Çalışkan S. New guidelines for the diagnosis, evaluation, and treatment of pediatric hypertension. Turk Pediatri Ars. 2020;55(1):11–22. doi: https://doi.org/10.14744/TurkPediatriArs.2020.92679
37. Bloetzer C, Paccaud F, Burnier M, et al. Performance of parental history for the targeted screening of hypertension in children. J Hypertens. 2015;33(6):1167–1173. doi: https://doi.org/10.1097/HJH.0000000000000560
38. Kapur G, Baracco R. Evaluation of hypertension in children. Curr Hypertens Rep. 2013;15(5):433–443. doi: https://doi.org/10.1007/s11906-013-0371-2
39. Spravochnik po vyyavleniyu patsientov s redkimi orfannymi boleznyami v khode provedeniya profilakticheskikh osmotrov. Baranov AA, Namazova-Baranova LS, Vashakmadze ND, eds. 2nd edn., revised and expanded. Moscow: Pediatr; 2025. 428 p. (In Russ).
40. Appel LJ. The Effects of Dietary Factors on Blood Pressure. Cardiol Clin. 2017;35(2):197–212. doi: https://doi.org/10.1016/j.ccl.2016.12.002
41. Vasyukova OV, Okorokov PL, Malievskiy OA, et al. Clinical guidelines “Obesity in children”. Obesity and metabolism. 2024;21(4):439–453. (In Russ). doi: https://doi.org/10.14341/omet13194
42. Kelly RK, Thomson R, Smith KJ, et al. Factors Affecting Tracking of Blood Pressure from Childhood to Adulthood: The Childhood Determinants of Adult Health Study. J Pediatr. 2015;167(6):1422– 1428.e2. doi: https://doi.org/10.1016/j.jpeds.2015.07.055
43. Campbell EK, Taillie L, Blanchard LM, et al. Post hoc analysis of food costs associated with Dietary Approaches to Stop Hypertension diet, whole food, plant-based diet, and typical baseline diet of individuals with insulin-treated type 2 diabetes mellitus in a nonrandomized crossover trial with meals provided. Am J Clin Nutr. 2024;119(3):769–778. doi: https://doi.org/10.1016/j.ajcnut.2023.12.023
44. Chaturvedi S, Lipszyc DH, Licht C, et al. Pharmacological interventions for hypertension in children. Evid Based Child Health. 2014;9(3):498–580. doi: https://doi.org/10.1002/ebch.1974
45. Samuels J, Bell C, Samuel J, Swinford R. Management of Hypertension in Children and Adolescents. Curr Cardiol Rep. 2015;17(12):107. doi: https://doi.org/10.1007/s11886-015-0661-1
46. Meyers KE, Cahill AM, Sethna C. Interventions for pediatric renovascular hypertension. Curr Hypertens Rep. 2014;16(4):422. doi: https://doi.org/10.1007/s11906-014-0422-3
47. Heger M, Willfort A, Neunteufl T, et al. Vascular dysfunction after coarctation repair is related to the age at surgery. Int J Cardiol. 2005;99(2):295–299. doi: https://doi.org/10.1016/j.ijcard.2004.02.001
48. Seirafi PA, Warner KG, Geggel RL, et al. Repair of coarctation of the aorta during infancy minimizes the risk of late hypertension. Ann Thorac Surg. 1998;66(4):1378–1382. doi: https://doi.org/10.1016/s0003-4975(98)00595-5
49. Khoury M, Urbina EM. Cardiac and Vascular Target Organ Damage in Pediatric Hypertension. Front Pediatr. 2018;6:148. doi: https://doi.org/10.3389/fped.2018.00148
50. Rovio SP, Pahkala K, Nevalainen J, et al. Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study. J Am Coll Cardiol. 2017;69(18):2279–2289. doi: https://doi.org/10.1016/j.jacc.2017.02.060
51. Lande MB, Kaczorowski JM, Auinger P, et al. Elevated blood pressure and decreased cognitive function among schoolage children and adolescents in the United States. J Pediatr. 2003;143(6):720–724. doi: https://doi.org/10.1067/S0022-3476(03)00412-8
52. Malcolm DD, Burns TL, Mahoney LT, Lauer RM. Factors affecting left ventricular mass in childhood: the Muscatine Study. Pediatrics. 1993;92(5):703–709.
53. de Simone G, Daniels SR, Devereux RB, et al. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol. 1992;20(5):1251–1260. doi: https://doi.org/10.1016/0735-1097(92)90385-z
54. Kulsum-Mecci N, Goss C, Kozel BA, et al. Effects of Obesity and Hypertension on Pulse Wave Velocity in Children. J Clin Hypertens (Greenwich). 2017;19(3):221–226. doi: https://doi.org/10.1111/jch.12892
55. Prasad RM, Bali A, Tikaria R. Microalbuminuria. 2023 May 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
56. Mitsnefes M, Ho PL, McEnery PT. Hypertension and progression of chronic renal insufficiency in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). J Am Soc Nephrol. 2003;14(10):2618–2622. doi: https://doi.org/10.1097/01.asn.0000089565.04535.4b
57. Warady BA, Abraham AG, Schwartz GJ, et al. Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort. Am J Kidney Dis. 2015;65(6):878–888. doi: https://doi.org/10.1053/j.ajkd.2015.01.008
Review
For citations:
Vasilyeva D.Yu., Andrianov N.A., Goncharova A.V., Klak A.I., Minnekhanova A.I., Adzhakavova J.G., Zakharova Yu.A., Emelianenko E.I., Lubenets M.E., Laputko V.V., Abdullina D.D., Yakupova E.R., Arustamova E.S. Modern Approaches to the Diagnosis, Treatment and Prevention of Arterial Hypertension in Children. Pediatric pharmacology. 2026;23(1):27-39. (In Russ.) https://doi.org/10.15690/pf.v23i1.3005
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