Correlations Between Obesity and Autoimmune Diseases
Anatoly I. Khavkin,
Valeriya P. Novikova,
Andrew V. Nalyotov,
Ludmila A. Podorova,
Marina Yu. Komissarova,
Dmitry I. Masyuta https://doi.org/10.15690/pf.v22i5.2972
Abstract
Chronic subacute inflammation typical for obesity may underlie the development of autoimmune diseases. Increased adipokines (such as leptin and resistin) and proinflammatory cytokines secretion are crucial in pathogenesis. Chronic inflammation in obesity promotes accelerated pancreatic β-cells apoptosis, leads to demyelination and damage to neuronal axons, intestinal microbiome changes, and impaired synthesis of thyroid hormones. Altogether, it can result in development of such conditions as type 1 diabetes mellitus, disseminated sclerosis, inflammatory bowel diseases, and autoimmune thyroiditis. Timely management obesity may prevent autoimmune diseases development.
Keywords
Supporting agencies: Not specified.
About the Authors
Anatoly I. Khavkin
Childhood Research Institute; Belgorod State National Research University
Russian Federation
Disclosure of interest:
Russian Federation
Anatoly I. Khavkin, MD, PhD, Professor
62, Bolshaya Serpukhovskaya Str., Moscow, 115093
Belgorod
Disclosure of interest:
Not declared.
Valeriya P. Novikova
Saint-Petersburg State Pediatric Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Valeriya P. Novikova, MD, PhD, Professor
Saint-Petersburg
Disclosure of interest:
Not declared.
Andrew V. Nalyotov
Donetsk State Medical University named after M. Gorky
Russian Federation
Disclosure of interest:
Russian Federation
Andrew V. Nalyotov, MD, PhD, Professor
Disclosure of interest:
Not declared.
Ludmila A. Podorova
Saint-Petersburg State Pediatric Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Ludmila A. Podorova, MD
Saint-Petersburg
Disclosure of interest:
Not declared.
Marina Yu. Komissarova
Saint-Petersburg State Pediatric Medical University; Children’s Clinical Center named after L. M. Roshal
Russian Federation
Disclosure of interest:
Russian Federation
Marina Yu. Komissarova, MD, PhD
Saint-Petersburg
Krasnogorsk
Disclosure of interest:
Not declared.
Dmitry I. Masyuta
Donetsk State Medical University named after M. Gorky
Russian Federation
Disclosure of interest:
Russian Federation
Dmitry I. Masyuta, MD, PhD
Disclosure of interest:
Not declared.
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Khavkin A.I., Novikova V.P., Nalyotov A.V., Podorova L.A., Komissarova M.Yu., Masyuta D.I. Correlations Between Obesity and Autoimmune Diseases. Pediatric pharmacology. 2025;22(5):624-631. (In Russ.) https://doi.org/10.15690/pf.v22i5.2972
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