BOTULINUM TOXIN A INJECTION PRECISION CONTROL AT SPASTIC FORMS OF CEREBRAL PALSY: METHODOLOGY CHOICE

The article provides general information on botulinum therapy in treating spastic forms of cerebral palsy; a review of modern botulinum toxin A drugs’ injection precision control methods at spasticity and other pathologic states is given; advantages and disadvantages of each injection control method are analyzed in detail. Special attention is paid to the substantiated choice of the injection control method in pediatric practice; muscles of the highest degree of complexity for botulinum therapy at spastic forms of cerebral palsy are described. The authors’ observations and results of applying ultrasound botulinum toxin A drugs’ injection control at different spasticity patterns in children are given.

1. Scott A. B. Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology. 1980; 87 (10): 1044–9.

2. Koman L. A., Mooney J. F., Smith B., Goodman A., Mulvaney T. Management of cerebral palsy with botulinum-A toxin: preliminary investigation. J Pediatr Orthop. 1993; 13 (4): 489–95.

3. Cosgrove A. P., Corry I. S., Graham H. K. Botulinum toxin in the management of the lower limb in cerebral palsy. Dev Med Child Neurol. 1994; 36 (5): 386–96.

4. Dutikova E.M., Lil'in E.T. Farmateka = Pharmateca. 2007; 7 (142): 37–42.

5. Zmanovskaya V.A. Klinicheskie varianty spasticheskikh form detskogo tserebral'nogo paralicha i otsenka effektivnosti botulinoterapii. Avtoref. dis. … kand. med. nauk [Clinical Types of Spastic Form of Cerebral Palsy and Evaluation of Botulinum Toxin Therapy. Author’s abstract]. Ekaterinburg, 2011. 22 p.

6. Kurenkov A.L., Batysheva T.T., Vinogradov A.V., Zyuzyaeva E.K. Zhurnal nevrologii i psikhiatrii – Journal of neuropathology and psychiatry. 2012; 7 (2): 24–28.

7. Graham H. K., Aoki K. R., Autti-Ramo I., Boyd R. N., Delgado M. R., Gaebler-Spira D. J., Gormley M. E., Guyer B. M., Heinen F., Holton A. F., Matthews D., Molenaers G., Motta F., Garcia Ruiz P. J., Wissel J. Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. Gait Posture. 2000; 11 (1): 67–79.

8. Aldosari M. S., Bohlega S. A., Al-Jadid M. A., El-Tamawy M. S., Ramadan M. A., Mousali Y. K., Yaghmour A. T., Kurdi A. M., Koussa S. H., Khamis S. N., Zeljic V. E., Shacfe H. D., Molteni F. G. Pan-Arab consensus statement on the use of botulinum toxin type A in spasticity management. Neurosciences (Riyadh). 2007; 12 (4): 279–81.

9. Heinen F., Desloovere K., Schroeder A. S., Berweck S., Borggraefe I., van Campenhout A., Andersen G. L., Aydin R., Becher J. G., Bernert G., Caballero I. M., Carr L., Valayer E. C., Desiato M. T., Fairhurst C., Filipetti P., Hassink R. I., Hustedt U., Jozwiak M., Kocer S. I., Kolanowski E., Krageloh-Mann I., Kutlay S., Maenpaa H., Mall V., McArthur P., Morel E., Papavassiliou A., Pascual-Pascual I., Pedersen S. A., Plasschaert F. S., van der Ploeg I., Remy-Neris O., Renders A., Di Rosa G., Steinlin M., Tedroff K., Valls J. V., Viehweger E., Molenaers G. The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy. Eur J Paediatr Neurol. 2010; 14 (1): 45–66.

10. Delgado M. R., Hirtz D., Aisen M., Ashwal S., Fehlings D. L., McLaughlin J., Morrison L. A., Shrader M. W., Tilton A., Vargus-Adams J. Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2010; 74 (4): 336–43.

11. Fehlings D., Novak I., Berweck S., Hoare B., Stott N. S., Russo R. N. Botulinum toxin assessment, intervention and followup for paediatric upper limb hypertonicity: international consensus statement. Eur J Neurol. 2010; 17 (Suppl. 2): 38–56.

12. Hoare B. J., Wallen M. A., Imms C., Villanueva E., Rawicki H. B., Carey L. Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE). Cochrane Database Syst Rev. 2010; 1.

13. Love S. C., Novak I., Kentish M., Desloovere K., Heinen F., Molenaers G., O'Flaherty S., Graham H. K. Botulinum toxin assessment, intervention and after-care for lower limb spasticity in children with cerebral palsy: international consensus statement. Eur J Neurol. 2010; 17 (Suppl. 2): 9–37.

14. Lim E. C., Quek A. M., Seet R. C. Accurate targeting of botulinum toxin injections: how to and why. Parkinsonism Relat Disord. 2011; 17 (Suppl. 1): 34–9.

15. Shaari C. M., Sanders I. Quantifying how location and dose of botulinum toxin injections affect muscle paralysis. Muscle Nerve. 1993; 16 (9): 964–9.

16. Borodic G. E., Ferrante R., Pearce L. B., Smith K. Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections. Mov Disord. 1994; 9 (1): 31–9.

17. Hsu T. S., Dover J. S., Arndt K. A. Effect of volume and concentration on the diffusion of botulinum exotoxin A. Arch Dermatol. 2004; 140 (11): 1351–4.

18. Kinnett D. Botulinum toxin A injections in children: technique and dosing issues. Am J Phys Med Rehabil. 2004; 83 (10 Suppl.): 59–64.

19. Shaari C. M., George E., Wu B. L., Biller H. F., Sanders I. Quantifying the spread of botulinum toxin through muscle fascia. Laryngoscope. 1991; 101 (9): 960–4.

20. Gracies J. M., Hefter H., Simpson D. M., Moore P. Spasticity in adults. In: Moore P., Naumann M., eds. Handbook of botulinum toxin treatment. Oxford: Blackwell Science. 2003. P. 219–71.

21. Pathak M. S., Nguyen H. T., Graham H. K., Moore A. P. Management of spasticity in adults: practical application of botulinum toxin. Eur J Neurol. 2006; 13 (Suppl. 1): 42–50.

22. Shortland A. P., Harris C. A., Gough M., Robinson R. O. Architecture of the medial gastrocnemius in children with spastic diplegia. Dev Med Child Neurol. 2002; 44 (3): 158–63.

23. Vasilescu D., Vasilescu D., Dudea S., Botar-Jid C., Sfrangeu S., Cosma D. Sonoelastography contribution in cerebral palsy spasticity treatment assessment, preliminary report: a systematic review of the literature apropos of seven patients. Med Ultrason. 2010; 12 (4): 306–10.

24. Childers M. K. The importance of electromyographic guidance and electrical stimulation for injection of botulinum toxin. Phys Med Rehabil Clin N Am. 2003; 14 (4): 781–92.

25. Chin T. Y., Nattrass G. R., Selber P., Graham H. K. Accuracy of intramuscular injection of botulinum toxin A in juvenile cerebral palsy: a comparison between manual needle placement and placement guided by electrical stimulation. J Pediatr Orthop. 2005; 25 (3): 286–91.

26. Wissel J., Poewe W. EMG for identification of dystonic, tremulous and spastic muscles and techniques for guidance of injections in Handbook of Botulinum Toxin Treatment, 2nd Edition (Moore N. M., ed.) Blackwell Science: Oxford. 2003. P. 76–98.

27. Comella C. L., Buchman A. S., Tanner C. M., Brown-Toms N. C., Goetz C. G. Botulinum toxin injection for spasmodic torticollis: increased magnitude of benefit with electromyographic assistance. Neurology. 1992; 42 (4): 878–82.

28. Dressler D. Electromyographic evaluation of cervical dystonia for planning of botulinum toxin therapy. Eur J Neurol. 2000; 7 (6): 713–8.

29. Traba Lopez A., Esteban A. Botulinum toxin in motor disorders: practical considerations with emphasis on interventional neurophysiology. Neurophysiol Clin. 2001; 31 (4): 220–9.

30. Schroeder A. S., Berweck S., Lee S. H., Heinen F. Botulinum toxin treatment of children with cerebral palsy — a short review of different injection techniques. Neurotox Res. 2006; 9 (2–3): 189–96.

31. Kalloo A. N., Pasricha P. J. Therapy of sphincter of Oddi dysfunction. Gastrointest Endosc Clin N Am. 1996; 6 (1): 117–25.

32. Lake J. M., Wong R. K. Review article: the management of achalasia — a comparison of different treatment modalities. Aliment Pharmacol Ther. 2006; 24 (6): 909–18.

33. Game X., Castel-Lacanal E., Bentaleb Y., Thiry-Escudie I., De Boissezon X., Malavaud B., Marque P., Rischmann P. Botulinum toxin A detrusor injections in patients with neurogenic detrusor overactivity significantly decrease the incidence of symptomatic urinary tract infections. Eur Urol. 2008; 53 (3): 613–8.

34. Lim E. C., Seet R. C. Botulinum toxin: description of injection techniques and examination of controversies surrounding toxin diffusion. Acta Neurol Scand. 2008; 117 (2): 73–84.

35. Reddymasu S. C., Singh S., Sankula R., Lavenbarg T. A., Olyaee M., McCallum R. W. Endoscopic pyloric injection of botulinum toxin-A for the treatment of postvagotomy gastroparesis. Am J Med Sci. 2009; 337 (3): 161–4.

36. Blitzer A. Spasmodic dysphonia and botulinum toxin: experience from the largest treatment series. Eur J Neurol. 2010; 17 (Suppl. 1): 28–30.

37. Glass G. A., Ku S., Ostrem J. L., Heath S., Larson P. S. Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollis. Parkinsonism Relat Disord. 2009 Sep; 15 (8): 610–3.

38. Yoon S. J., Ho J., Kang H. Y., Lee S. H., Kim K. I., Shin W. G., Oh J. M. Low-dose botulinum toxin type A for the treatment of refractory piriformis syndrome. Pharmacotherapy. 2007; 27 (5): 657–65.

39. Fischer A. Q., Carpenter D. W., Hartlage P. L., Carroll J. E., Stephens S. Muscle imaging in neuromuscular disease using computerized real-time sonography. Muscle Nerve. 1988; 11 (3): 270–5.

40. Schiano T. D., Fisher R. S., Parkman H. P., Cohen S., Dabezies M., Miller L. S. Use of high-resolution endoscopic ultrasonography to assess esophageal wall damage after pneumatic dilation and botulinum toxin injection to treat achalasia. Gastrointest Endosc. 1996; 44 (2): 151–7.

41. Berweck S., Feldkamp A., Francke A., Nehles J., Schwerin A., Heinen F. Sonography-guided injection of botulinum toxin A in children with cerebral palsy. Neuropediatrics. 2002; 33 (4): 221–3.

42. Berweck S., Heinen F. Use of botulinum toxin in pediatric spasticity (cerebral palsy). Mov Disord. 2004; 19 (Suppl. 8): 162–7.

43. Willenborg M. J., Shilt J. S., Smith B. P., Estrada R. L., Castle J. A., Koman L. A. Technique for iliopsoas ultrasound-guided active electromyography-directed botulinum a toxin injection in cerebral palsy. J Pediatr Orthop. 2002; 22 (2): 165–8.

44. Westhoff B., Seller K., Wild A., Jaeger M., Krauspe R. Ultrasoundguided botulinum toxin injection technique for the iliopsoas muscle. Dev Med Child Neurol. 2003; 45 (12): 829–32.

45. Alter K. E. High-frequency ultrasound guidance for neurotoxin injections. Phys Med Rehabil Clin N Am. 2010; 21 (3): 607–30.

46. Hustedt U. Botulinumtoxin bei spastischen Bewegungsstorungen. Ultraschallgestutzte Technik und Anwendung. KVM. 2010. P. 13–15.

47. Berweck S., Schroeder A. S., Fietzek U. M., Heinen F. Sonography- guided injection of botulinum toxin in children with cerebral palsy. Lancet. 2004; 363 (9404): 249–50.

48. Py A. G., Zein Addeen G., Perrier Y., Carlier R. Y., Picard A. Evaluation of the effectiveness of botulinum toxin injections in the lower limb muscles of children with cerebral palsy. Preliminary prospective study of the advantages of ultrasound guidance. Ann Phys Rehabil Med. 2009; 52 (3): 215–23.

49. Kwon J. Y., Hwang J. H., Kim J. S. Botulinum toxin a injection into calf muscles for treatment of spastic equinus in cerebral palsy: a controlled trial comparing sonography and electric stimulationguided injection techniques: a preliminary report. Am J Phys Med Rehabil. 2010; 89 (4): 279–86.

50. Baranov A.A., Klochkova O.A., Kurenkov A.L., Namazova-Baranova L. S., Nikitin S.S., Artemenko A.R., Mamed"yarov A.M. Pediatricheskaya farmakologiya – Pediatric pharmacology. 2012; 9 (6): 24–32.