Reproductive Health of Female Patients with Connective Tissue Dysplasia
Irina V. Karachentsova,
Anastasia V. Goryainova,
Elena V. Sibirskaya,
Marina Yu. Alekhina,
Amina F. Askerova https://doi.org/10.15690/pf.v20i3.2573
Abstract
Connective tissue dysplasia is congenital anomaly manifesting as different organ's and system's alterations: locomotor, skin, visceral dysfunctions. This article presents literature review covering such topical issues as female reproductive system features affected by mesenchymal pathology (undifferentiated forms of connective tissue dysplasia) and its medicamentous management (microelements, hormonal drugs, adaptogens). The analysis of original studies on this topic has revealed that connective tissue dysplasia has significant effect on female reproductive function development and can be complicated by various menstrual dysfunctions (hypomenorrhea syndrome, oligomenorrhea, opsomenorrhea, uterine bleedings, and secondary amenorrhea) as well as by endocrine changes (anti-Mullerian hormone deficiency, hypoprolactinaemia, hypoestrogenemia, etc.). Gestation and delivery features in patients with connective tissue dysplasia (preeclampsia, premature birth, and fetal abnormalities) were also revealed.
Supporting agencies: Not specified
About the Authors
Irina V. Karachentsova
Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
MD, PhD.
1 Ostrovityanova Str., building 7, Moscow, 117997
Tel.: +7 (925) 505-31-04
Disclosure of interest:
Not declared
Anastasia V. Goryainova
Russian Children's Clinical Hospital, Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
MD, PhD.
Moscow
Disclosure of interest:
Not declared
Elena V. Sibirskaya
Pirogov Russian National Research Medical University; Russian Children's Clinical Hospital, Pirogov Russian National Research Medical University; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Dolgoprudnenskaya Central City Hospital
Russian Federation
Disclosure of interest:
Russian Federation
MD, PhD, Professor.
Moscow
Disclosure of interest:
Not declared
Marina Yu. Alekhina
Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Not declared
Amina F. Askerova
Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Not declared
References
1. Displazii soedinitel'noi tkani: Clinical guidelines. Moscow: Russian Scientific Medical Society of Internal Medicine; 2017. 181 p. (In Russ).
2. Burrows NP. The molecular genetics of the Ehlers-Danlos syndrome. Clin Experim Dermatol. 1999;24(2):99-106. doi: https://doi.org/10.1046/j.1365-2230.1999.00427.x
3. Han YP, Zhou L, Wang J. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem. 2004;279(6):4820-4828. doi: https://doi.org/10.1074/jbc.M310999200
4. Kadler KE, Hill A, Canty-Laird EG. Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol. 2008;20(5):495-501. doi: https://doi.org/10.1016/j.ceb.2008.06.008
5. Kadurina TI, Gorbunova VN. Displaziya soedinitel'noi tkani: guidelines for doctors. St. Petersburg: Elbi; 2009. 714 p. (In Russ).
6. Kadurina TI, Abbakumova LN. Pediatricheskie aspekty diagnostiki sindroma gipermobil'nosti sustavov. Pediatria. Journal n.a. G.N. Speransky. 2013;92(4):46-51. (In Russ).
7. Nechaeva GI, Yakovlev VM, Konev VP, et al. Displaziya soedinitel'noi tkani: osnovnye klinicheskie sindromy, formulirovka diagnoza, lechenie. Lechaschi Vrach. 2008;(1):23-34. (In Russ).
8. Trushina OV, Orlova VS, Kalashnikova IV. Fizicheskoe razvitie i somaticheskii fon devushek-podrostkov, stradayushchikh dismenoreei, sochetannoi s displaziei soedinitel'noi tkani. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya. 2018;41(1):36-45. (In Russ). doi: https://doi.org/10.18413/2075-4728-2018-41-1-36-45
9. Stepanova EA, Kolesnikov SI. Menstrual function disorders in adolescent girls with dysplasia of connective tissues. Acta Biomedica Scientifica. 2012;(2-2):49-53. (In Russ).
10. Khuraseva AB. Rol' sindroma zaderzhki vnutriutrobnogo razvitiya ploda v geneze klinicheskikh proyavlenii displazii soedinitel'noi tkani u devochek-podrostkov. Zhurnal akusherstva i zhenskikh boleznei. 2009;58(6):65-69. (In Russ).
11. Skosyreva GA, Peterson VD, Ryabichenko TI, Kim LB. Stanovlenie reproduktivnogo zdorov'ya devochek-podrostkov s sindromom nedifferentsirovannoi displazii soedinitel'noi tkani. Kazan Medical Journal. 2007;88(5):120-122. (In Russ).
12. Zoloto EV. Predictors of reproductive health disorders in adolescent girls with undifferentiated connective tissue dysplasia. Archives of Clinical and Experimental Medicine. 2019;28(2):160-167. (In Russ).
13. National recommendations of the Russian scientific society of internal medicine for diagnostics, treatment and rehabilitation of patients with connective tissue dysplasia. Medical News of the North Caucasus. 2016;11(1):2-76. (In Russ). doi: https://doi.org/10.14300/mnnc.2016.11001
14. Smirnova TL, Gerasimova LI. Specific Clinical Features of Undifferentiated Connective Tissue Dysplasia Syndrome. Doctor.Ru. 2018;(8):40-44. (In Russ). doi: https://doi.org/10.31550/1727-2378-2018-152-8-40-44
15. Zoloto EV. Features of hormonal status of teenage girls with menstrual cycle disorders associated with undifferentiated connective tissue dysplasia. Medical and Social Problems Of Family. 2019;24(1):23-27. (In Russ).
16. Goryainova AV, Karachentsova IV, Sibirskaya EV, et al. Features of pubertal development of adolescent girls with cystic fibrosis. Rossiyskiy Pediatricheskiy Zhurnal = Russian Pediatric Journal. 2022;25(4):230-235. (In Russ). doi: https://doi.org/10.46563/1560-9561-2022-25-4-230-235
17. Orlova VS, Trushina OV, Kalashnikova IV. Dysplasia of the connective tissue is a factor, aggravating menstrual pain syndrome in adolescent girls. Journal of Obstetrics and Women's Diseases. 2018;67(1):38-46. (In Russ). doi: https://doi.org/10.17816/jowd67138-46
18. Nechayeva GI, Druk IV. Psychosomatic correlations in dysplasia of connective tissue. Siberian Herald of Psychiatry and Addiction Psychiatry. 2005;(3):78-80. (In Russ).
19. Kogan M, Nikolenko V, Zanozin A, et al. The syndrome of undifferentiated connective tissue dysplasia in a combination with hereditary thrombophilia as a cause of primary female infertility. Medical News of the North Caucasus. 2016;11(2-2):324-326. (In Russ). doi: https://doi.org/10.14300/mnnc.2016.11067
20. Il'ina IYu, Chikisheva AA. Course of the pregnancy in women with connective tissue disorders. Russian Journal of Woman and Child Health. 2020;3(3):182-188. (In Russ). doi: https://doi.org/10.32364/2618-8430-2020-3-3-182-188
21. Pavlov O, Lukina T, Kozina E. Management of pregnant women with undifferentiated connective tissue dysplasia. Journal of New Medical Technologies. EJournal. 2015;(4). (In Russ). doi: https://doi.org/10.12737/16165
22. Gevorgyan AP, Sibirskaya EV, Adamyan LV, Arslanyan KN. Primary dysmenorrhea in adolescent girls as a predictor of the development of undifferentiated connective tissue dysplasia. Russian Journal of Human Reproduction. 2017;23(3):77-85. (In Russ). doi: https://doi.org/10.17116/repro201723377-85
23. Gumenyuk OI, Chernenkov YuV. Dysmenorrhea in adolescent girls. Meditinskaya sestra. 2015;(3):31-33. (In Russ).
24. Kucherov BA, Kravtsov YuA, Yavorskaya MV, Matveev CV. Possibilities of treatment of connective tissue dysplasia in children and adolescents (literature review). Ural Medical Journal. 2019;(2):20-25. (In Russ). doi: https://doi.org/10.25694/URMJ.2019.02.21
25. Patent No. 2657751 C1 Russian Federation, IPC A61K 31/565, A61K 31/568, A61K 38/24. Method of age-specific therapy and prevention of connective tissue dysplasia: № 2016129888: declare 20.07.2016: publ. 15.06.2018. Kravtsov YuA, Yavorskaya MV, Pakholyuk YuP. 14 p. (In Russ).
26. Gipogonadizm u detei i podrostkov: Clinical guidelines. Russian Association of Endocrinology; 2016. 56 p. (In Russ).
27. Korennaya VV. NSAIDs in the treatment of patients with primary dysmenorrhea. Gynecology. 2015;17(1):55-58. (In Russ).
28. Jurova EG, Rjabichenko TI, Skosyreva GA, et al. Rehabilitation of the teenagers with reproductive function disorders, associated with the connective tissue dysplasia at children sanatorium “Belokuriha”. Kuban Scientific Medical Bulletin. 2009;(6):83-86. (In Russ).
Review
For citations:
Karachentsova I.V., Goryainova A.V., Sibirskaya E.V., Alekhina M.Yu., Askerova A.F. Reproductive Health of Female Patients with Connective Tissue Dysplasia. Pediatric pharmacology. 2023;20(3):267-273. (In Russ.) https://doi.org/10.15690/pf.v20i3.2573
Views:
544
Email this article 