Effects of Carbamazepine on Cardiovascular System: Literature Review
https://doi.org/10.15690/pf.v19i6.2491
Abstract
Carbamazepine is an anticonvulsant that is commonly used in neurological and psychiatric patients to treat epileptic seizures, neuropathic pain, or bipolar disorder. Carbamazepine side effects, as well as side effects of many antiepileptic drugs, include cardiotoxic effects such as atrioventricular block, bradycardia, and cardiac rhythm disorders. However, carbamazepine has also been reported to have antiarrhythmic, normotimic, and membrane-stabilizing effects. This results in its administration to treat arrhythmias in children. Based on literature, carbamazepine administration as anti-arrhythmic drug is known in cases where the basic therapy was ineffective. The medication is not registered anywhere in the world for this purpose. Thus, it can be administered only off-label. The aim of our literature review is to analyze and summarize the existing data on carbamazepine effects on cardiovascular system, to determine its safety as anti-arrhythmic drug, and to describe various factors fostering its side effects.
About the Authors
Leonid S. Gordeev
National Medical Research Center of Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
MD
2 Lomonosovsky Ave., building 2, Moscow, 119296
Disclosure of interest:
Not declared.
Ekaterina K. Kulbachinskaya
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
MD
Moscow
Disclosure of interest:
Not declared.
Vera V. Bereznitskaya
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
MD, PhD
Moscow
Disclosure of interest:
Not declared.
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Review
For citations:
Gordeev L.S., Kulbachinskaya E.K., Bereznitskaya V.V. Effects of Carbamazepine on Cardiovascular System: Literature Review. Pediatric pharmacology. 2022;19(6):484-491. (In Russ.) https://doi.org/10.15690/pf.v19i6.2491
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