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Management of Children with Speech Disorders via Transcranial Magnetic Stimulation: Non-Randomized Controlled Study

https://doi.org/10.15690/pf.v19i5.2466

Abstract

Background. Speech development impairment is urgent and common problem in pediatric neurology. Transcranial magnetic stimulation (TMS) is one of the promising treatment variants for children with speech disorders. Objective. The aim of the study is to evaluate efficacy and safety of the developed approaches to TMS usage in the management of children with speech disorders. Methods. It was non-randomized controlled study. It included 46 children with speech disorders aged from 3 to 6.5 years. All children were divided into two groups comparable by gender and age: 26 children of the treatment group received TMS course, 20 children of the control group received treatment with hopantenic acid. All patients with speech disorders underwent psychological and pedagogical evaluation of speech and cognitive development, electroencephalography (EEG) before and after treatment. Moreover, comparative analysis of TMS and nootropic therapy efficacy was carried out. Specialized examination of speech and cognitive development was also performed via E.A. Strebeleva method for psychological and pedagogical diagnosis of children development. Furthermore, we carried out side reactions / adverse events registration according to patients and/or their parents complaints confirmed by physical examination, patient’s behavior observation, data from specially developed questionnaire for assessing child’s behavior and well-being (filled up by parents). Finally, we evaluated brain bioelectric activity recorded by EEG. Results. The study results have shown that it is possible to achieve significant positive dynamics in cognitive and speech development in preschool children with speech disorders in both groups (TMS course and medical treatment). But hereby, TMS treatment has demonstrated significantly higher positive dynamics in two out of the three evaluated parameters. There were no cases of adverse events in TMS group leading to early course discontinuation. Conclusion. TMS is non-invasive and safe method for treatment of children with speech disorders. This study has demonstrated the efficacy of the method in the field of personalized management of children with impaired speech and cognitive development.

About the Authors

Julia V. Nesterova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 5547-6239

10 Fotievoy street, 119333, Moscow


Disclosure of interest:

Not declared.



George A. Karkashadze
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 6248-0970

Moscow


Disclosure of interest:

Lecturing for pharmaceutical companies Sanofi, Geropharm.



Leonid M. Yatsik
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 3696-1027

Moscow


Disclosure of interest:

Not declared.



Leyla S. Namazova-Baranova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD, Professor, Academician of the RAS

eLibrary SPIN: 1312-2147

Moscow


Disclosure of interest:

Receiving research grants from pharmaceutical companies Pierre Fabre, Genzyme Europe B.V., Astra Zeneca PLC, Gilead / PRA “Pharmaceutical Research Associates CIS”, Teva Branded Pharmaceutical Products R&D, Inc / “PPD Development (Smolensk)” LLC, “Stallerzhen S.A.” / “Quintiles GMBH” (Austria).



Elena A. Vishneva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD, Professor

eLibrary SPIN: 1109-2810

Moscow


Disclosure of interest:

Not declared.



Elena V. Kaytukova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

eLibrary SPIN: 1272-7036

Moscow


Disclosure of interest:

Not declared.



Kamilla E. Efendieva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

eLibrary SPIN: 5773-3901

Moscow


Disclosure of interest:

Not declared.



Daria A. Bushueva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 8124-5030

Moscow


Disclosure of interest:

Not declared.



Tinatin Yu. Gogberashvili
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 5723-4805

Moscow


Disclosure of interest:

Not declared.



Tatiana A. Konstantinidi
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 7971-2040

Moscow


Disclosure of interest:

Not declared.



Natalia E. Sergeeva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

eLibrary SPIN: 9332-5010

Moscow


Disclosure of interest:

Not declared.



Safarbegim H. Sadilloeva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

eLibrary SPIN: 3203-2569

Moscow


Disclosure of interest:

Not declared.



Marina A. Kurakina
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

eLibrary SPIN: 7472-6286

Moscow


Disclosure of interest:

Not declared.



Julia E. Kazanceva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

Moscow


Disclosure of interest:

Not declared.



Inessa A. Povalyaeva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

Moscow


Disclosure of interest:

Not declared.



Nadezhda A. Ulkina
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

Moscow


Disclosure of interest:

Not declared.



Tatiana A. Salimgareeva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

Moscow


Disclosure of interest:

Not declared.



Natalia S. Sergienko
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 3786-8520

Moscow


Disclosure of interest:

Not declared.



Oksana D. Mescheryakova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

eLibrary SPIN: 45510-3459

Moscow


Disclosure of interest:

Not declared.



Viktor V. Altunin
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 4818-6385

Moscow


Disclosure of interest:

Not declared.



Elizaveta V. Leonova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

eLibrary SPIN: 7004-9106

Moscow


Disclosure of interest:

Not declared.



Elena S. Zibrova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation

MD

Moscow


Disclosure of interest:

Not declared.



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Review

For citations:


Nesterova J.V., Karkashadze G.A., Yatsik L.M., Namazova-Baranova L.S., Vishneva E.A., Kaytukova E.V., Efendieva K.E., Bushueva D.A., Gogberashvili T.Yu., Konstantinidi T.A., Sergeeva N.E., Sadilloeva S.H., Kurakina M.A., Kazanceva J.E., Povalyaeva I.A., Ulkina N.A., Salimgareeva T.A., Sergienko N.S., Mescheryakova O.D., Altunin V.V., Leonova E.V., Zibrova E.S. Management of Children with Speech Disorders via Transcranial Magnetic Stimulation: Non-Randomized Controlled Study. Pediatric pharmacology. 2022;19(5):380-393. (In Russ.) https://doi.org/10.15690/pf.v19i5.2466

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