Management of Children with Speech Disorders via Transcranial Magnetic Stimulation: Non-Randomized Controlled Study
https://doi.org/10.15690/pf.v19i5.2466
Abstract
Background. Speech development impairment is urgent and common problem in pediatric neurology. Transcranial magnetic stimulation (TMS) is one of the promising treatment variants for children with speech disorders. Objective. The aim of the study is to evaluate efficacy and safety of the developed approaches to TMS usage in the management of children with speech disorders. Methods. It was non-randomized controlled study. It included 46 children with speech disorders aged from 3 to 6.5 years. All children were divided into two groups comparable by gender and age: 26 children of the treatment group received TMS course, 20 children of the control group received treatment with hopantenic acid. All patients with speech disorders underwent psychological and pedagogical evaluation of speech and cognitive development, electroencephalography (EEG) before and after treatment. Moreover, comparative analysis of TMS and nootropic therapy efficacy was carried out. Specialized examination of speech and cognitive development was also performed via E.A. Strebeleva method for psychological and pedagogical diagnosis of children development. Furthermore, we carried out side reactions / adverse events registration according to patients and/or their parents complaints confirmed by physical examination, patient’s behavior observation, data from specially developed questionnaire for assessing child’s behavior and well-being (filled up by parents). Finally, we evaluated brain bioelectric activity recorded by EEG. Results. The study results have shown that it is possible to achieve significant positive dynamics in cognitive and speech development in preschool children with speech disorders in both groups (TMS course and medical treatment). But hereby, TMS treatment has demonstrated significantly higher positive dynamics in two out of the three evaluated parameters. There were no cases of adverse events in TMS group leading to early course discontinuation. Conclusion. TMS is non-invasive and safe method for treatment of children with speech disorders. This study has demonstrated the efficacy of the method in the field of personalized management of children with impaired speech and cognitive development.
About the Authors
Julia V. NesterovaRussian Federation
MD, PhD
eLibrary SPIN: 5547-6239
10 Fotievoy street, 119333, Moscow
Disclosure of interest:
Not declared.
George A. Karkashadze
Russian Federation
MD, PhD
eLibrary SPIN: 6248-0970
Moscow
Disclosure of interest:
Lecturing for pharmaceutical companies Sanofi, Geropharm.
Leonid M. Yatsik
Russian Federation
MD
eLibrary SPIN: 3696-1027
Moscow
Disclosure of interest:
Not declared.
Leyla S. Namazova-Baranova
Russian Federation
MD, PhD, Professor, Academician of the RAS
eLibrary SPIN: 1312-2147
Moscow
Disclosure of interest:
Receiving research grants from pharmaceutical companies Pierre Fabre, Genzyme Europe B.V., Astra Zeneca PLC, Gilead / PRA “Pharmaceutical Research Associates CIS”, Teva Branded Pharmaceutical Products R&D, Inc / “PPD Development (Smolensk)” LLC, “Stallerzhen S.A.” / “Quintiles GMBH” (Austria).
Elena A. Vishneva
Russian Federation
MD, PhD, Professor
eLibrary SPIN: 1109-2810
Moscow
Disclosure of interest:
Not declared.
Elena V. Kaytukova
Russian Federation
MD, PhD
eLibrary SPIN: 1272-7036
Moscow
Disclosure of interest:
Not declared.
Kamilla E. Efendieva
Russian Federation
MD, PhD
eLibrary SPIN: 5773-3901
Moscow
Disclosure of interest:
Not declared.
Daria A. Bushueva
Russian Federation
MD
eLibrary SPIN: 8124-5030
Moscow
Disclosure of interest:
Not declared.
Tinatin Yu. Gogberashvili
Russian Federation
MD
eLibrary SPIN: 5723-4805
Moscow
Disclosure of interest:
Not declared.
Tatiana A. Konstantinidi
Russian Federation
MD
eLibrary SPIN: 7971-2040
Moscow
Disclosure of interest:
Not declared.
Natalia E. Sergeeva
Russian Federation
eLibrary SPIN: 9332-5010
Moscow
Disclosure of interest:
Not declared.
Safarbegim H. Sadilloeva
Russian Federation
eLibrary SPIN: 3203-2569
Moscow
Disclosure of interest:
Not declared.
Marina A. Kurakina
Russian Federation
eLibrary SPIN: 7472-6286
Moscow
Disclosure of interest:
Not declared.
Julia E. Kazanceva
Russian Federation
Moscow
Disclosure of interest:
Not declared.
Inessa A. Povalyaeva
Russian Federation
Moscow
Disclosure of interest:
Not declared.
Nadezhda A. Ulkina
Russian Federation
Moscow
Disclosure of interest:
Not declared.
Tatiana A. Salimgareeva
Russian Federation
Moscow
Disclosure of interest:
Not declared.
Natalia S. Sergienko
Russian Federation
MD, PhD
eLibrary SPIN: 3786-8520
Moscow
Disclosure of interest:
Not declared.
Oksana D. Mescheryakova
Russian Federation
MD, PhD
eLibrary SPIN: 45510-3459
Moscow
Disclosure of interest:
Not declared.
Viktor V. Altunin
Russian Federation
MD
eLibrary SPIN: 4818-6385
Moscow
Disclosure of interest:
Not declared.
Elizaveta V. Leonova
Russian Federation
MD
eLibrary SPIN: 7004-9106
Moscow
Disclosure of interest:
Not declared.
Elena S. Zibrova
Russian Federation
MD
Moscow
Disclosure of interest:
Not declared.
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Review
For citations:
Nesterova J.V., Karkashadze G.A., Yatsik L.M., Namazova-Baranova L.S., Vishneva E.A., Kaytukova E.V., Efendieva K.E., Bushueva D.A., Gogberashvili T.Yu., Konstantinidi T.A., Sergeeva N.E., Sadilloeva S.H., Kurakina M.A., Kazanceva J.E., Povalyaeva I.A., Ulkina N.A., Salimgareeva T.A., Sergienko N.S., Mescheryakova O.D., Altunin V.V., Leonova E.V., Zibrova E.S. Management of Children with Speech Disorders via Transcranial Magnetic Stimulation: Non-Randomized Controlled Study. Pediatric pharmacology. 2022;19(5):380-393. (In Russ.) https://doi.org/10.15690/pf.v19i5.2466