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Clinical Cases: Diagnostic Errors of Mastocytosis Cutaneous Forms in Children

https://doi.org/10.15690/pf.v19i3.2439

Abstract

Background. Mastocytosis refers to the group of rare diseases with pathological mast cells accumulation in tissues. Although diagnosis of cutaneous mastocytosis is not usually difficult for experienced physicians, misdiagnosis is possible.

Clinical cases description. The authors describe two clinical cases of patients with mastocytosis cutaneous form, observed due to the skin rashes and without any correctly established diagnosis.

Conclusion. Patients with mastocytosis require specific living conditions and regular dynamic monitoring to prevent disease progression and complications development.

About the Authors

Lianna K. Aslamazyan
Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

str. 1, 10 Fotievoy street, 119333, Moscow

eLibrary SPIN: 1413-5684

 


Disclosure of interest:

Not declared



Kamilla E. Efendieva
Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

Moscow

eLibrary SPIN: 5773-3901

 


Disclosure of interest:

Not declared.



Anna A. Alekseeva
Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery
Russian Federation

MD, PhD

Moscow

eLibrary SPIN: 7253-7970

 


Disclosure of interest:

Not declared.



Julia G. Levina
Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD, PhD

Moscow

eLibrary SPIN: 4626-2800

 


Disclosure of interest:

Not declared.



Alina R. Pankova
Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation

MD

Moscow

eLibrary SPIN: 7741-5933

 


Disclosure of interest:

Not declared.



References

1. Potapenko VG, Skoryukova KA, Lisukova YV, et al. Mastocytosis in children: characteristic of a group of 111 patients. Pediatria. Journal n.a. G.N. Speransky. 2018;97(4):135–140. (In Russ). doi: https://doi.org/10.24110/0031-403X-2018-97-4-135-140

2. Nemat K, Abraham S. Cutaneous mastocytosis in childhood. Allergol Select. 2022;6:1–10. doi: https://doi.org/10.5414/ALX02304E

3. Giona F. Pediatric Mastocytosis: An Update. Mediterr J Hematol Infect Dis. 2021;13(1):e2021069. doi: https://doi.org/10.4084/MJHID.2021.069

4. Brockow K. Epidemiology, prognosis, and risk factors in mastocytosis. Immunol Allergy Clin North Am. 2014;34(2):283–295. doi: https://doi.org/10.1016/j.iac.2014.01.003

5. Klaiber N, Kumar S, Irani AM. Mastocytosis in Children. Curr Allergy Asthma Rep. 2017;17(11):80. doi: https://doi.org/10.1007/s11882-017-0748-4

6. Leung AKC, Lam JM, Leong KF. Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management. Curr Pediatr Rev. 2019;15(1):42–46. doi: https://doi.org/10.2174/1573396315666181120163952

7. Carter MC, Clayton ST, Komarow HD, et al. Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis. J Allergy Clin Immunol. 2015;136(6):1673–1679.e3. doi: https://doi.org/10.1016/j.jaci.2015.04.024

8. Melikyan AL, Subortseva IN, Shuvaev VA, et al. National clinical recommendations for the diagnosis and treatment of mastocytosis. Russian Journal of Hematology and Transfusiology (Gematologiya I transfuziologiya). 2021;66(2):280–311. (In Russ). doi: https://doi.org/10.35754/0234-5730-2021-66-2-280-311


Review

For citations:


Aslamazyan L.K., Efendieva K.E., Alekseeva A.A., Levina J.G., Pankova A.R. Clinical Cases: Diagnostic Errors of Mastocytosis Cutaneous Forms in Children. Pediatric pharmacology. 2022;19(3):258-262. (In Russ.) https://doi.org/10.15690/pf.v19i3.2439

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ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)