COVID-19 Dermatological Manifestations in Children
https://doi.org/10.15690/pf.v19i2.2398
Abstract
This article describes various COVID-19 dermatological manifestations that can develop in children. Their incidence and clinical features are described. Chilblain-like lesions were considered as the most typical in children population after coronavirus infection. Description of skin manifestations in multisystem inflammatory syndrome in children is also presented, issues of laboratory diagnosis are covered as well.
About the Authors
Vladislav V. Ivanchikov
Research Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of Surgery
Russian Federation
Disclosure of interest:
Russian Federation
MD.
Moscow.
eLibrary SPIN: 1078-5850
Disclosure of interest:
Confirmed the absence of a reportable conflict of interests
Eduard T. Ambarchyan
Research Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of Surgery
Russian Federation
Disclosure of interest:
Russian Federation
MD, PhD.
1а Litovsky bulvar, 117593 Moscow.
tel.: +7 (915) 400-00-02
eLibrary SPIN: 4878-5562
Disclosure of interest:
Receiving research grants from pharmaceutical companies Eli Lilly, Novartis, AbbVie, Pfizer, Amryt Pharma plc, scientific consultant of Johnson & Johnson
Anastasia D. Kuzminova
Research Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of Surgery
Russian Federation
Disclosure of interest:
Russian Federation
MD.
Moscow.
eLibrary SPIN: 7014-2239
Disclosure of interest:
Confirmed the absence of a reportable conflict of interests
References
1. Kabeerdoss J, Pilania RK, Karkhele R, et al. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int. 2021;41(1):19-32. doi: https://doi.org/10.1007/s00296-020-04749-4
2. Nuno-Gonzalez A, Martin-Carrillo P, Magaletsky K, et al. Prevalence of mucocutaneous manifestations in 666 patients with COVID-19 in a field hospital in Spain: oral and palmoplantar findings. Br J Dermatol. 2021;184(1):184-185. doi: https://doi.org/10.1111/bjd.19564
3. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. doi: https://doi.org/10.1056/NEJMoa2001017
4. Morris SB, Schwartz NG, Patel P, et al. Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March-August 2020. MMWR Morb Mortal Wkly Rep. 2020;69(40):1450-1456. doi: https://doi.org/10.15585/mmwr.mm6940e1
5. Marzano AV, Cassano N, Genovese G, et al. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue. Br J Dermatol. 2020;183(3):431-442. doi: https://doi.org/10.1111/bjd.19264
6. Labe P, Ly A, Sin C, et al. Erythema multiforme and Kawasaki disease associated with COVID-19 infection in children. J Eur Acad Dermatol Venereol. 2020;34(10):e539-e541. doi: https://doi.org/10.1111/jdv.16666
7. Seque CA, Enokihara MMSES, Porro AM, et al. Skin manifestations associated with COVID-19. An Bras Dermatol. 2022;97(1):75-88. doi: https://doi.org/10.1016/j.abd.2021.08.002
8. Tan SW, Tam YC, Oh CC. Skin manifestations of COVID-19: A worldwide review. JAAD Int. 2021;2:119-133. doi: https://doi.org/10.1016/j.jdin.2020.12.003
9. COVID Symptom Study App (archive). In: British Association of Dermatologists. Available online: https://covidskinsigns.com. Accessed on April 17, 2022.
10. Rocha KO, Zanuncio VV, Freitas BAC, et al. “COVID toes”: A meta-analysis of case and observational studies on clinical, histopathological, and laboratory findings. Pediatr Dermatol. 2021;38(5):1143-1149. doi: https://doi.org/10.1111/pde.14805
11. Andina D, Noguera-Morel L, Bascuas-Arribas M, et al. Chilblains in children in the setting of COVID-19 pandemic. Pediatr Dermatol. 2020;37(3):406-411. doi: https://doi.org/10.1111/pde.14215
12. Andina D, Belloni-Fortina A, Bodemer C, et al. Skin manifestations of COVID-19 in children: Part 1. Clin Exp Dermatol. 2021;46(3):444-450. doi: https://doi.org/10.1111/ced.14481
13. Nemazee L, Elangasinghe V. A Case of ‘Long Covid Toes' with Associated Cryofibrinogenaemia. In: 20th ESPD Annular Meeting, May 12-14, 2021. On-Line Poster.
14. Volpi S, Picco P, Caorsi R, et al. Type I interferonopathies in pediatric rheumatology. Pediatr Rheumatol Online J. 2016;14(1):35. doi: https://doi.org/10.1186/s12969-016-0094-4
15. Magro C, Mulvey JJ, Berlin D, et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl Res. 2020;220:1-13. doi: https://doi.org/10.1016/j.trsl.2020.04.007
16. Gianotti R, Recalcati S, Fantini F, et al. Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infectionby COVID-19intheNorthernPartof Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases. Am J Dermatopathol. 2020;42(8):564-570. doi: https://doi.org/10.1097/DAD.0000000000001707
17. Andina D, Belloni-Fortina A, Bodemer C, et al. Skin manifestations of COVID-19 in children: Part 2. Clin Exp Dermatol. 2021;46(3):451-461. doi: https://doi.org/10.1111/ced.14482
18. Estebanez A, Perez-Santiago L, Silva E, et al. Cutaneous manifestations in COVID-19: a new contribution. J Eur Acad Dermatol Venereol. 2020;34(6):e250-e251. doi: https://doi.org/10.1111/jdv.16474
19. Young S, Fernandez AP. Skin manifestations of COVID-19. Cleve Clin J Med. 2020 May 14. Online ahead of print. doi: https://doi.org/10.3949/ccjm.87a.ccc031
20. Marzano AV, Genovese G, Fabbrocini G, et al. Varicella-like exanthem as a specific COVID-19-associated skin manifestation: Multicenter case series of 22 patients. J Am Acad Dermatol. 2020;83(1):280-285. doi: https://doi.org/10.1016/j.jaad.2020.04.044
21. Criado PR, Abdalla BMZ, de Assis IC, et al. Are the cutaneous manifestations during or due to SARS-CoV-2 infection/ COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms. Inflamm Res. 2020;69(8):745-756. doi: https://doi.org/10.1007/s00011-020-01370-w
22. de Masson A, Bouaziz JD, Sulimovic L, et al. Chilblains is a common cutaneous finding during the COVID-19 pandemic: A retrospective nationwide study from France. J Am Acad Dermatol. 2020;83(2):667-670. doi: https://doi.org/10.1016/j.jaad.2020.04.161
23. Ventura-Espejo L, Gracia-Darder I, Escriba-Bori S, et al. Patient with H syndrome, cardiogenic shock, multiorgan infiltration, and digital ischemia. Pediatr Rheumatol Online J. 2021;19(1):104. doi: https://doi.org/10.1186/s12969-021-00586-2
24. Manalo IF, Smith MK, Cheeley J, et al. A dermatologic manifestation of COVID-19: transient livedoreticularis. J Am Acad Dermatol. 2020;83(2):700. doi: https://doi.org/10.1016/j.jaad.2020.04.018
25. Galeotti C, Bayry J. Autoimmune and inflammatory diseases following COVID-19. Nat Rev Rheumatol. 2020;16(8):413-414. doi: https://doi.org/10.1038/s41584-020-0448-7
26. Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395(10239):1771-1778. doi: https://doi.org/10.1016/S0140-6736(20)31103-X
27. Young TK, Shaw KS, Shah JK, et al. Mucocutaneous Manifestations of Multisystem Inflammatory Syndrome in Children During the COVID-19 Pandemic. JAMA Dermatol. 2021;157(2):207-212. doi: https://doi.org/10.1001/jamadermatol.2020.4779
28. Naka F, Melnick L, Gorelik M, Morel KD. A dermatologic perspective on multisystem inflammatory syndrome in children. Clin Dermatol. 2021;39(1):163-168. doi: https://doi.org/10.1016/j.clindermatol.2020.09.003
29. Miller J, Cantor A, Zachariah P, et al. Gastrointestinal Symptoms as a Major Presentation Component of a Novel Multisystem Inflammatory Syndrome in Children That Is Related to Coronavirus Disease 2019: A Single Center Experience of 44 Cases. Gastroenterology. 2020;159(4):1571-1574.e2. doi: https://doi.org/10.1053/j.gastro.2020.05.079
30. Andina D, Belloni-Fortina A, Bodemer C, et al. Skin manifestations of COVID-19 in children: Part 3. Clin Exp Dermatol. 2021;46(3):462-472. doi: https://doi.org/10.1111/ced.14483
31. Salian VS, Wright JA, Vedell PT, et al. COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies. Mol Pharm. 2021;18(3):754-771. doi: https://doi.org/10.1021/acs.molpharmaceut.0c00608
32. Centers for Disease Control and Prevention. Interim Guidelines for collecting, handling, and testing clinical specimens from patients under investigation (PUIs) for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) — Version 2.1. Available online: https://www.cdc.gov/coronavirus/mers/downloads/Guidelines-Clinical-Specimens.pdf. Accessed on April 17, 2022.
33. Colonna C, Monzani NA, Rocchi A, et al. Chilblain-like lesions in children following suspected COVID-19 infection. Pediatr Dermatol. 2020;37(3):437-440. doi: https://doi.org/10.1111/pde.14210
34. Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017-1032. doi: https://doi.org/10.1038/s41591-020-0968-3
35. Cazzato, G., Foti, C., Colagrande, A., et al. Skin Manifestation of SARS-CoV-2: The Italian Experience. J Clin Med. 2021;10(8):1566. doi: https://doi.org/10.3390/jcm10081566
36. Ahmed M, Advani S, Moreira A, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020;26:100527. doi: https://doi.org/10.1016/j.eclinm.2020.100527
Review
For citations:
Ivanchikov V.V., Ambarchyan E.T., Kuzminova A.D. COVID-19 Dermatological Manifestations in Children. Pediatric pharmacology. 2022;19(2):105-114. (In Russ.) https://doi.org/10.15690/pf.v19i2.2398
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