NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT
https://doi.org/10.15690/pf.v10i4.760
Abstract
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report the description of natural regulatory T lymphocytes subpopulations and their transcription factor FOXP3 in frequently ill children. Dynamic changes in Treg concentration and expression of FOXP3 in groups of healthy, children with RRI and children with combination of RRI and allergy are described. It is proved that in case of allergy despite its aetiology and severity, children have increased concentration of CD4+CD25hi in blood. We suggest that in children with RRI and allergy an insufficient function of Treg is compensated by the increased number of cells and in this case they have a remission of allergy. Treatment of acute allergy by topical or inhaled glucocorticosteriods leads to the increased expression of molecular marker FOXP3 and can be considered as one of their modes of action.
About the Authors
A. D. Pertseva
Pirogov Russian National Research Medical University, Moscow
Russian Federation
teaching assistant of Theoretical Pediatrics Department № 1 of Faculty of Pediatrics of Pirogov Russian National
Research Medical University
Russian Federation
teaching assistant of Theoretical Pediatrics Department № 1 of Faculty of Pediatrics of Pirogov Russian National
Research Medical University
N. Z. Zokirov
Research Center of The Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
V. V. Troshina
Federal Medical-Biological Agency, Children’s Health
Russian Federation
Russian Federation
L. S. Namazova-Baranova
Federal Medical-Biological Agency, Children’s Health
The Russian Research Medical University named after N.I. Pirogov, Ministry of Health and Social Development of Russia,
Chair of Intermediate Level Pediatrics № 1 of Pediatric Faculty, Moscow
First Sechenov Moscow State Medical University of the Ministry of Health of the Russian Federation
Central Children’s Hospital of Federal Medical-Biological Agency of Russia (CCH of FMBA), Moscow
Russian Federation
Russian Federation
S. Y. Tarakanova
Research Center of The Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Pertseva A.D., Zokirov N.Z., Troshina V.V., Namazova-Baranova L.S., Tarakanova S.Y. NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT. Pediatric pharmacology. 2013;10(4):96-105. (In Russ.) https://doi.org/10.15690/pf.v10i4.760
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