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MUCOLYTIC THERAPY IN INFANTS

https://doi.org/10.15690/pf.v10i5.830

Abstract

When prescribing mucolytic therapy for bronchopulmonary diseases to infants, it is necessary to consider not only peculiarities of a small child’s respiratory tract, but also action of mucolytic drugs. The authors exemplify their data on efficacy and safety of the use of mucolytics in children under 2 years of age with acetylcysteine.


About the Authors

I. V. Davydova
Scientific Center of Children’s Health, Moscow
Russian Federation

PhD, head of the department of studies of new technologies in children’s development peculiarities and outpatient health level monitoring of the research institute of preventive pediatrics and medical rehabilitation at the Scientific Center of Children’s Health



T. V. Turti
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation


V. V. Altunin
Scientific Center of Children’s Health, Moscow, Russian Federation
Russian Federation


References

1. Zharkova N. E. Russkii meditsinskii zhurnal = Russian medical journal. 2006; 6: 1171–1174.

2. Klyachkina I. L. Consilium medicum = Consilium medicum. 2008; 10 (3): 124–128.

3. Namazova-Baranova L. S., Alekseeva A. A., Torshkhoeva R. M., Vishneva E. A., Levina Yu. G. Praktika pediatra = Pediatrician practice. 2011; december: 5–9.

4. Namazova-Baranova L. S., Nisevich L. L., Volkov K. S., Vazhnova I. M. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2008; 5 (3): 64–71.

5. Baranov A. A., Al'bitskii V. Yu. Mediko-sotsial'nye problemy sovremennogo sirotstva [Medical and Social Problems of the Contemporary Orphanhood]. Moscow, Soyuz pediatrov Rossii, 2009. pp. 62–71.

6. Namazova-Baranova L. S., Torshkhoeva R. M., Botvin'eva V. V., Tagizade T. G., Taranushenko T. E. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2006; 3 (1): 13–17.

7. Davydova I. V., Yatsyk G. V., Lukina O. F. et al. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2008; 5 (6): 42–44.

8. Davydova I. V., Yatsyk G. V., Tresorukova O. F. Rossiiskii pediatricheskii zhurnal = Russian pediatrical journal. 2008; 6: 10–13.

9. Namazova-Baranova L. S., Turti T. V., Davydova I. V. et al. Floumetriya spokoinogo dykhaniya u detei pervogo goda zhizni. Metodicheskie rekomendatsii [Flowmetry of Breathing in Infants. Methodical Recommendations]. Moscow, Pediatr", 2012. 31 p.

10. Volkov K. S., Nisevich L. L., Namazova-Baranova L. S., Filyanskaya E. G., Alekseeva A. A., Barannik V. A. Voprosy sovremennoi pediatrii = Current pediatrics. 2013; 12 (1): 112–116.

11. Ushkalova E. A. Farmateka = Pharmateca. 2007; 17: 30–36.

12. Aruoma O. L., Halliwell B., Hoey B. M. et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide and hypochlorous acid. Free Radic. Biol. Med. 1989; 6 (6): 593–597.

13. De Flora S., Cesarone C. F., Balansy R. M. et al. N-acetylcysteine. The experimental background. J. Cell. Biochem. 1995; 22: 33–41.

14. Droge W. Cystein and Glutathione Deficiency in AIDS Patients. Pharmacology. 1993; 46: 61–65.

15. Lu Q., Bjorkhem I. et al. N-acetylcysteine improves microcirculatory flow during smoring: new effects of an old drug with possible benefits for smokers. Clin. Cardiol. 2001; 24: 511.

16. Kelly G. S. Clinical applications of N-acetylcysteine. Alt Medical Review. 1998; 24 (2): 114–127.

17. Ostroumova M. N., Kovalenko N. G., Bershtein L. M. Eksperimental'naya onkologiya = Experimental oncology. 1999; 16: 96–101.

18. Grandjean E. M., Berthet P., Ruffman R. et al. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: meta-analysis of published double-blind, placebo-controlled clinical trial. Clin. Therapy. 2000; 22: 209–221.

19. Instruktsiya po meditsinskomu primeneniyu preparata ATsTs (N-atsetil-L-tsistein). Proizvoditel' «Geksal AG» [Instructions for Medical Use of the Drug NAC (N-acetyl-L-cysteine). Manufacturer "Ghexal AG"].

20. Lui R., Nair D., Ix J. et al. N-acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and metaanalysis. J. Gen. Intern. Med. 2005; 20: 193–200.

21. Stey C., Steurer J., Bachmann S. et al. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur. Respir. J. 2000; 16: 253–262.

22. Duijvestijn Y. C. M., Mourdi N., Smuchny J. et al. Acetylcysteine and carbocysteine for acute upper and low respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease (Review). Cochrane Database Syst. Rev. 2010; 9: 1–22.

23. Chalumeau M., Cheron G. Assathiany R., Moulin F. et al. Mucolytic agents for acute respiratory tract infections in infants: pharmacoepidemiologic problem? Archives de Pediatrie. 2002; 9: 1128–1136.

24. Ergreteau L., Gaillard D., Jouet J. B. et al. Effect of carbocysteine on mucus and respiratory mucosa in children with recurrent bronchitis. Eur. Respir. J. 1992; 5: 301.

25. Davydova I. V., Turti T. V., Namazova-Baranova L. S. et al. Pediatricheskaya farmakologiya = Pediatric pharmacolog. 2012; 9 (2): 67–73.


Review

For citations:


Davydova I.V., Turti T.V., Altunin V.V. MUCOLYTIC THERAPY IN INFANTS. Pediatric pharmacology. 2013;10(5):90-93. https://doi.org/10.15690/pf.v10i5.830

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ISSN 1727-5776 (Print)
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