PULSE WAVE VELOCITY AND CENTRAL AORTIC PRESSURE IN OBESE CHILDREN ACCORDING TO THE NON-INVASIVE ARTERIOGRAPHY RESULTS

The article presents information value of non-invasive arteriography, which reveals early signs of cardiovascular pathology formation in children, using a large number of trials in children. The authors examined predictors of cardiovascular catastrophes’ development, confirmed in adults: aortic wall’s stiffness, central aortic pressure and pulse pressure – that have not been sufficiently studied in children yet. The article shows that the high-technology method of non-invasive arteriography allows revealing changes of these parameters in children on the preclinical stage. It also shows their correlation with body mass index, fatty hepatosis, direct correlation of weight gain with connection of pulse wave velocity and central blood pressure and importance of follow-up evaluation of these parameters. Heterogeneity of the group of obese children in terms of these parameters is a premise for development of individual approach to control and prevention of cardiovascular complications’ development risk in childhood.

1. Baranov A. A. Pediatriya. Zhurnal im. G. N. Speranskogo = PEDIATRIYA - MOSCOW. 2005; 3: 4–7.

2. WHO. Available at: http://www.who.int/dietphysicalactivity/childhood/ru

3. Oganov R. G. Arkh. patologii = Achive of pathology. 1992; 4: 13–15.

4. Logacheva O. S., O. V. Kozhevnikova, A. E. Pal'tseva, L. S. Namazova-Baranova, A. K. Gevorkyan Pediatricheskaya farmakologiya = Pediatric pharmacology. 2013; 10 (2): 117–120.

5. Baranov A. A., Al'bitskii V. Yu., Vinyarskaya I. V. Voprosy sovremennoi pediatrii = Current pediatrics. 2005; 4 (2): 7–12.

6. Logachyeva O. S., Kozhevnikova O. V., Namazova-Baranova L. S. Parameters of arterial stiffness and lipid metabolism in children with obesity. 7th international symposium on arterial stiffness and the 5th congress of the Hungarian society of arterial stiffness. Depresen. Hungarian. 2011. P. 25.

7. Kozhevnikova O. V., Smirnov I. E., Kucherenko A. G., Dombrovskaya I. A., Kupriyanova O. O., Ivanov A. P. et al. Pediatriya = Pediatrics. 1996; 6: 25–29.

8. WHO. Available at: http://www.who.int/dietphysicalactivity/childhood/ru

9. Logacheva O. S., Kozhevnikova O. V., Namazova-Baranova L. S., Pal'tseva A. E., Ryzhkova L. A., Shirokova I. V. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2009; 6 (5): 38–41.

10. Mitchell G. F., Hwang S. J., Vasan R. S. et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2009; 121 (4): 505–511.

11. Cecelja M., Chowienczyk Ph. Role of arterial stiffness in cardiovascular disease. J. R. Soc. Med. Cardiovasc. 2012; 1 (4): 11.

12. Arterial'naya gipertenziya = Hipertension. 2010; 1 (9): 9–28.

13. Miklosh I., Khidvegi E. V., Iiesh M., Bentsur B., Bochkei R., Radgeber L. et al. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2013; 10 (2): 72–78.

14. Wilkinson I. B., MacCallum H., Flint L. et al. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000; 525 (Pt. 1): 263–270.

15. Dzyak G. V., Kolesnik T. V., Kolesnik E. L. Tsentral'noe aortal'noe davlenie na fone dlitel'noi kombinirovannoi antigipertenzivnoi terapii. Ukr. Med. Chasopis. = Ukrainian medical journal. 2012; 4 (90): VII/VIII. Available at: http://www.umj.com.ua

16. Rosario A. S., Kurth B. M., Stolzenberg H., Ellert U., Neuhauser H. Body mass index percentiles for children and adolescents in Germany based on a nationally representative sample (KiGGS 2003–2006). Eur. J. Clin. Nutr. 2010; 64: 341–349.

17. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114 (2 Suppl. 4): 555–576.

18. Boutouyrie P., Bussy C., Lacolley P. et al. Association between local pulse pressure, mean blood pressure, and large-artery remodeling. Circulation. 1999; 100 (13): 1387–1393.

19. Boitsov S. A. Bolezni serdtsa i sosudov = Heart and vascular diseases. 2006; 1 (3): 36.

20. Roman M. J., Okin P. M., Kizer J. R. et al. Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study. J. Hypertens. 2010; 28 (2): 384–388.

21. Roman M. J., Devereux R. B., Kizer J. R. et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. 2007; 50 (1): 197–203.

22. Wang K. L., Cheng H. M., Chuang S. Y. et al. Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J. Hypertens. 2009; 27 (3): 461–467.