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Педиатрическая фармакология

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Организация грудного вскармливания в отделениях реанимации и интенсивной терапии недоношенных детей: дискуссионные вопросы

https://doi.org/10.15690/pf.v16i3.2027

Полный текст:

Аннотация

Приоритетность обеспечения грудного вскармливания при выхаживании недоношенных младенцев не подвергается сомнению. Для детей, родившихся преждевременно, вскармливание грудным молоком обеспечивает двойной эффект, снижая риск как ближайших, так и отдаленных последствий, связанных с недоношенностью. В этой связи на международном уровне предпринимаются чрезвычайные шаги по поощрению и поддержке вскармливания новорожденных грудным молоком, в том числе в отделениях интенсивной терапии. Собственное молоко матери является первым выбором для кормления недоношенного ребенка. В последние годы обсуждаются проблемы качества и безопасности сцеженного грудного молока — как пастеризованного, так и свежего — для новорожденных пациентов отделений реанимаций и интенсивной терапии. Авторы указывают, что процедуры обработки и условия хранения сцеженного грудного молока существенно различаются, отсутствуют единые критерии его микробиологической безопасности. Все это ограничивает использование сцеженного грудного молока, прежде всего у недоношенных новорожденных. Помимо опасности бактериального инфицирования, в отношении недоношенных младенцев обсуждается риск заражения цитомегаловирусом (ЦМВ) при использовании свежего молока ЦМВ-серопозитивной матери. В обзоре рассматриваются критерии риска инфицирования детей ЦМВ и показания к избирательной обработке грудного молока для инактивации вероятного патогена.

Об авторах

И. А. Беляева
Морозовская детская городская клиническая больница; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова
Россия

Беляева Ирина Анатольевна - доктор медицинских наук, профессор РАН, руководитель неонатологической службы ГБУЗ «Морозовская ДГКБ ДЗМ»; профессор кафедры факультетской педиатрии ФГБОУ ВО «РНИМУ им. Н.И. Пирогова».

119049, Москва, 4-й Добрынинский пер., д. 1/9, тел.: +7 (499) 236-31-21



Л. С. Намазова-Баранова
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова; Центральная клиническая больница Российской академии наук; Белгородский государственный национальный исследовательский университет
Россия

Москва



Н. Н. Володин
Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачёва
Россия

Москва



Е. Е. Петряйкина
Морозовская детская городская клиническая больница; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова
Россия

Москва



Список литературы

1. Torchin H, Ancel PY, Jarreau PH, Goffinet F. Epidemiology of preterm birth: Prevalence, recent trends, short- and long-term outcomes. J Gynecol Obstet Biol Reprod. 2015;44:723-731. doi: 10.1016/j.jgyn.2015.06.010.

2. Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, et al. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: Results of the EPIPAGE-2 cohort study. JAMA Pediatr. 2015;169:230-238. doi: 10.1001/jamapedi-atrics.2014.3351.

3. Vidyasagar D. Half a century of evolution of neonatology: a witness's story. Indian J Pediatr. 2015;82:1117-1125. doi: 10.1007/s12098-015-1838-8.

4. Cleminson JS, Zalewski SP, Embleton ND. Nutrition in the preterm infant: What's new? Curr Opin Clin Nutr Metab Care. 2016;19:220-225. doi: 10.1097/MC0.0000000000000270.

5. Lewis ED, Richard C, Larsen BM, Field CJ. The importance of human milk for immunity in preterm infants. Clin Perinatol. 2017;44:23-47. doi: 10.1016/j.clp.2016.11.008.

6. Spiegler J, PreuG M, Gebauer C, et al. On behalf of the german neonatal network. does breastmilk influence the development of bronchopulmonary dysplasia? J Pediatr. 2016;169:76-80. doi: 10.1016/j.jpeds.2015.10.080.

7. Bharwani SK, Green BF, Pezzullo JC, et al. Systematic review and meta-analysis of human milk intake and retinopathy of prematurity: a significant update. J Perinatol. 2016;36:913-920. doi: 10.1038/jp.2016.98.

8. Donovan SM. The role of lactoferrin in gastrointestinal and immune development and function: a preclinical perspective. J Pediatr. 2016;173:16-28. doi: 10.1016/j.jpeds.2016.02.072.

9. Horta BL, Loret de Mola C, Victora CG. Breastfeeding and intelligence: a systematic review and meta-analysis. Acta Paediatr. 2015;104:14-19. doi: 10.1111/apa.13139.

10. Belfort MB, Rifas-Shiman SL, Kleinman KP et al. Infant feeding and childhood cognition at ages 3 and 7 years: effects of breastfeeding duration and exclusivity. JAMA Pediatr. 2013;167:836-844. doi: 10.1001/jamapediatrics.2013.455.

11. Victora CG, Horta BL, de Mola CL, et al. Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Health. 2015;3:199-205. doi: 10.1016/S2214-109X(15)70002-1.

12. Van Odijk J, Kull I, Borres MP et al. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy. 2003;58(9):833-843. doi: 10.1034/j.1398-9995.2003.00264.x.

13. Dogaru CM, Nyffenegger D, Pescatore AM, et al. Breastfeeding and childhood asthma: systematic review and meta-analysis. Am J Epidemiol. 2014;179:1153-1167. doi: 10.1093/aje/kwu072.

14. Amitay EL, Keinan-Boker L. Breastfeeding and childhood leukemia incidence: a meta-analysis and systematic review. JAMA Pediatr. 2015;169(6):e151025. doi: 10.1001/jamapediatrics.2015.1025.

15. Pudla KJ, Gonzalez-Chica DA, de Vasconcelos Fde A. [Effect of breastfeeding on obesity of schoolchildren: influence of maternal education. (Article in Portuguese).] Rev Paul Pediatr. 2015;33(3):295-302. doi: 10.1016/j.rpped.2015.01.004.

16. Horta BL, Loret de Mola C, Victora CG. Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 2015;104:30-37. doi: 10.1111/apa.13133.

17. Singhal A. The impact of human milk feeding on long-term risk of obesity and cardiovascular disease. Breastfeed Med. 2019;14(S1):S9-S10. doi: 10.1089/bfm.2019.0037.

18. Rollins NC, Bhandari N, Hajeebhoy N, et al. Why invest, and what it will take to improve breastfeeding practices? Lancet. 2016;387:491-504. doi: 10.1016/S0140-6736(15)01044-2.

19. World Health Organization (WHO). Guidelines on optimal feeding of low birth-weight infants in low- and middle-income countries. Geneva: WHO; 2011.

20. American Academy of Pediatrics (AAP). Breastfeeding and use of human milk. Pediatrics. 2012;129:e827-841. doi: 10.1542/peds.2011-3552.

21. Arslanoglu S, Corpeleijn W, Moro G, et al. Donor human milk for preterm infants: current evidence and research directions. J Pediatr Gastroenterol Nutr. 2013;57:535-542 doi: 10.1097/MPG.0b013e3182a3af0a.

22. World Health Organization (WHO) / United Nations Children's Fund (UNICEF). Meeting on infant and young child feeding. J Nurs Midw. 1980;25(3):31-38. doi: 10.1016/0091-2182(80)90051-8.

23. Weaver G, Bertino E, Gebauer C, et al. Recommendations for the establishment and operation of human milk banks in Europe: a consensus statement from the European Milk Bank Association (EMBA). Front Pediatr. 2019;7:53. doi: 10.3389/fped.2019.00053.

24. Best practice for expressing, storing and handling human milk in hospitals, homes, and child care settings. 4th edition, HMBANA; 2019. Available from: https://www.hmbana.org/our-work/publica-tions.html.

25. Picaud JC, Houeto N, Buffin R, et al. Additional protein fortification is necessary in extremely low-birth-weight infants fed human milk. J Pediatr Gastroenterol Nutr. 2016;63:103-5. doi: 10.1097/MPG.0000000000001142.

26. Peters MD, McArthur A, Munn Z. Safe management of expressed breast milk: a systematic review. Women Birth J Aust Coll Midwives. 2016;29:473-481. doi: 10.1016/j.wombi.2016.05.007.

27. Omarsdottir S, Casper C, Akerman A, et al. Breastmilk handling routines for preterm infants in Sweden: a national cross-sectional study. Breastfeed Med Off J Acad Breastfeed Med. 2008;3:165-170. doi: 10.1089/bfm.2007.0033.

28. Steele C, Collins E, eds. Infant and pediatric feedings: guidelines for preparation of human milk and formula in health care facilities. 3rd ed. Chicago, IL: Academy of Nutrition and Dietetics; 2018. 248 р.

29. Moro GE, Arslanoglu S, Bertino E, et al. Human milk in feeding premature infants: from tradition to bioengineering. Proceedings of a consensus development conference — EXPO-2015. J Ped Gastroenterol Nutr. 2015;61:S1-19. doi: 10.1097/MPG.0000000000000897.

30. Picaud JC, Buffin R, Gremmo-Feger G, et al. Review concludes that specific recommendations are needed to harmonise the provision of fresh mother's milk to their preterm infants. Acta Paediatr. 2018;107:1145-1155. doi: 10.1111/apa.14259.

31. Ojo-Okunola A, Nicol M, du Toit E. Human breast milk bacteriome in health and disease. Nutrients. 2018;10:1643. doi: 10.3390/nu10111643.

32. Soeorg H, Metsvaht T, Eelmae I, et al. Coagulase-negative staphylococci in human milk from mothers of preterm compared with term neonates. J Hum Lact. 2017;3:329-340. doi: 10.1177/0890334417691505.

33. Committee on Nutrition; AAP Section on Breastfeeding; Committee on Fetus and Newborn. Donor human milk for the high-risk infant: preparation, safety, and usage options in the united states. Pediatrics. 2017;139:e20163440. doi: 10.1542/peds.2016-3440.

34. Gras-Le Guen C, Lepelletier D, Debillon T, et al. Contamination of a milk bank pasteurizer causing a Pseudomonas aeruginosa outbreak in a neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2003;88:F434-435. doi: 10.1136/fn.88.5.f434.

35. Behari P Englund J, Alcasid G, et al. Transmission of methi-cillin-resistant Staphylococcus aureus to preterm infants through breast milk. Infect Control Hosp Epidemiol. 2004;25:78-80. doi: 10.1086/502476.

36. Landers S, Updegrove K. Bacteriological screening of donor human milk before and after Holder pasteurization. Breastfeed Med. 2010;5:117-121. doi: 10.1089/bfm.2009.0032.

37. Schanler R, Fraley J, Lau C, et al. Breastmilk culture and infection in extremely premature infants. J Perinatol. 2011;31:335-338. doi: 10.1038/jp.2011.13.

38. Eglash A; The Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #8 Human milk storage information for home use for full-term infants. Breastfeed Med. 2010;5:127-130. doi: 10.1089/bfm.2017.29047.aje.

39. AFSSA Recommandations d’hygiene pour la preparation et la conservation des biberons. Juillet; 2005. [accessed on 4 July 2015] Available from: https://www.anses.fr/fr/system/files/MIC-Ra-BIB. pdf.

40. Klotz D, Jansen S, Gebauer C, Fuchs H. Handling of breast milk by neonatal units: large differences in current practices and beliefs. Front Pediatr. 2018;6:235. doi: 10.3389/fped.2018.00235.

41. Steele C. Best practices for handling and administration of expressed human milk and donor human milk for hospitalized preterm infants. FrontNutr. 2018;5:76. doi: 10.3389/fnut.2018.00076.

42. Barbas KH. Mother's milk technicians: a new standard of care. J Hum Lact. 2013;29:323-327. doi: 10.1177/0890334413492910.

43. Omarsdottir S, Casper C, Naver L, et al. Cytomegalovirus infection and neonatal outcome in extremely preterm infants after freezing of maternal milk. Pediatr Infect Dis J. 2015;34:482-489. doi: 10.1097/INF.0000000000000619.

44. Cossey V, Johansson A-B, de Halleux V, Vanhole C. The use of human milk in the neonatal intensive care unit: practices in Belgium and Luxembourg. Breastfeeding medicine. 2012;7(4):302-306. doi: 10.1089/bfm.2011.0112.

45. Lloyd ML, Hod N, Jayaraman J, et al. Inactivation of cytomegalovirus in breast milk using ultraviolet-c irradiation: opportunities for a new treatment option in breast milk banking. PLoS ONE. 2016;11(8):e0161116. doi: 10.1371/journal.pone.0161116.

46. Hamprecht K, Maschmann J, Vochem M, et al. Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding. Lancet. 2001;357:513-518. doi: doi: 10.1016/ S0140-6736(00)04043-5.

47. Mehler K, Oberthuer A, Lang-Roth R, Kribs A. High rate of symptomatic cytomegalovirus infection in extremely low gestational age preterm infants of 22-24 weeks' gestation after transmission via breast milk. Neonatology. 2014;105:27-32. doi: 10.1159/000355306.

48. Gartner LM, Morton J, Lawrence RA, et al. Breastfeeding and the use of human milk. Pediatrics. 2005;115:496-506. doi: 10.1542/peds.2004-2491.

49. Vochem M, Hamprecht K, Jahn G, Speer CP Transmission of cytomegalovirus to preterm infants through breast milk. Pediatr Infect Dis J. 1998;17(1):53-58. doi: 10.1097/00006454-199801000-00012.

50. Hamprecht K, Goelz R. Postnatal cytomegalovirus infection through human milk in preterm infants: transmission, clinical presentation, and prevention. Clin Perinatol. 2017;44:121-130. doi: 10.1016/j.clp.2016.11.012.

51. Hamprecht K, Maschmann J, Jahn G, et al. Cytomegalovirus transmission to preterm infants during lactation. J Clin Virol. 2008;41:198-205. doi: 10.1016/j.jcv.2007.12.005.

52. Lopes A-A, Champion V, Mitanchez D. Nutrition of preterm infants and raw breast milk-acquired cytomegalovirus infection: French National Audit of Clinical Practices and Diagnostic Approach. Nutrients. 2018;10:1119. doi: 10.3390/nu10081119.

53. Hamprecht K, Maschmann J, Muller D, et al. Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing. Pediatr Res. 2004;56:529-535. doi: 10.1203/01.PDR.0000139483.35087.BE.

54. Omarsdottir S, Casper C, Naver L, et al. CMV infection and neonatal outcome in extremely preterm infants after freezing of maternal milk. Pediatr Infect Dis J. 2015;34:482-489. doi: 10.1097/INF.0000000000000619.

55. Stock K, Griesmaier E, Brunner B, et al. Pasteurization of breastmilk decreases the rate of postnatally acquired cytomegalovirus infections, but shows a nonsignificant trend to an increased rate of necrotizing enterocolitis in very preterm infants-a preliminary study. Breastfeed Med. 2015;10:113-117. doi: 10.1089/bfm.2014.0108.

56. Yoo HS, Sung SI, Jung YJ, et al. Prevention of cytomegalovirus transmission via breast milk in extremely low birth weight infants. Yonsei Med J. 2015;56:998-1006. doi: 10.3349/ymj.2015.56.4.998.

57. Lanzieri TM, Dollard SC, Josephson CD, et al. Breast milk-acquired cytomegalovirus infection and disease in VLBW and premature infants. Pediatrics. 2013;131:e1937-e1945. doi: 10.1542/peds.2013-0076.

58. Goelz R, Meisner C, Bevot A, et al. Long-term cognitive and neurological outcome of preterm infants with postnatally acquired CMV infection through breast milk. Arch Dis Child Fetal Neonatal Ed. 2013;98:F430-433. doi: 10.1136/archdis-child-2012-303384.

59. Josephson CD, Caliendo AM, Easley KA, et al. Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study. JAMA Pediatr. 2014;168:1054-1062. doi: 10.1001/jamapediat-rics.2014.1360.

60. Gunkel J, Wolfs TF, de Vries LS, Nijman J. Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment. Expert Rev Anti Infect Ther. 2014;12: 1345-1355. doi: 10.1586/14787210.2014.966080.

61. Kurath S, Halwachs-Baumann G, Muller W, Resch B. Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review. Clin Microbiol Infect. 2010;16:1172-1178. doi: 10.1111/j.1469-0691.2010.03140.x.

62. Kurath S, Resch B. Cytomegalovirus and transmission via breast milk: how to support breast milk to premature infants and prevent severe infection? Pediatr Infect Dis J. 2010;29:680-681. doi: 10.1097/INF.0b013e3181dc4d4a.

63. Bevot A, Hamprecht K, Krageloh-Mann I, et al. Long-term outcome in preterm children with human cytomegalovirus infection transmitted via breast milk. Acta Paediatr. 2012;101(4):e167-172. doi: 10.1111/j.1651-2227.2011.02538.x.

64. Okulu E, Akin IM, Atasay B, et al. Severe postnatal cytomegalovirus infection with multisystem involvement in an extremely low birth weight infant. J Perinatol. 2012;32:72-74. doi: 10.1038/jp.2011.58.

65. Lopes A-A, Belhabri S, Karaoui L. Erratum: clinical findings and autopsy of a preterm infant with breast milk-acquired cytomegalovirus infection. AJP Rep. 2016;6:e367. doi: 10.1055/s-0036-1593627.

66. Kelly MS, Benjamin DK, Puopolo KM, et al. Postnatal cytomegalovirus infection and the risk for bronchopulmonary dysplasia. JAMA Pediatr. 2015;169:e153785. doi: 10.1001/jamapediat-rics.2015.3785.

67. Ross SA, Ahmed A, Palmer AL, et al. Detection of congenital cytomegalovirus infection by real-time polymerase chain reaction analysis of saliva or urine specimens. J Infect Dis. 2014;210:1415-1418. doi: 10.1093/infdis/jiu263.

68. Boppana SB, Ross SA, Shimamura M, et al. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011;364:2111-2118. doi: 10.1056/NEJMoa1006561.

69. Romero-Gomez MP, Cabrera M, Montes-Bueno MT, et al. Evaluation of cytomegalovirus infection in low-birth weight children by breast milk using a real-time polymerase chain reaction assay. J Med Virol. 2015;87:845-850. doi: 10.1002/jmv.24101.

70. Hamprecht K, Vochem M, Baumeister A, et al. Detection of cytomegaloviral DNA in human milk cells and cell free milk whey by nested PCR. J Virol Methods. 1998;70:167-176. doi: 10.1016/S1386-6532(03)00074-X.

71. Zwiauer K. Pravention von CMV-infektionen bei fruhge-borenen durch muttermilch. Monatsschrift Kinderheilkunde. 2009;157(8):795-797. doi: 10.1007/s00112-009-2019-5.

72. Risiko der Zytomegalievirus-Infektion durch Mutter-milchernahrung von sehr unreifen Fruhgeborenen. Empfehlung der Nationalen Stillkommission [cited 2006 Juni 7]. Available from: https://studylibde.com/doc/2484799/empfehlungen-risiko-der-zytomegalievirus.


Рецензия

Для цитирования:


Беляева И.А., Намазова-Баранова Л.С., Володин Н.Н., Петряйкина Е.Е. Организация грудного вскармливания в отделениях реанимации и интенсивной терапии недоношенных детей: дискуссионные вопросы. Педиатрическая фармакология. 2019;16(3):152-158. https://doi.org/10.15690/pf.v16i3.2027

For citation:


Belyaeva I.A., Namazova-Baranova L.S., Volodin N.N., Petryaykina E.E. Organization of breastfeeding in neonatal intensive care units: discussion issues. Pediatric pharmacology. 2019;16(3):152-158. (In Russ.) https://doi.org/10.15690/pf.v16i3.2027

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