SENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGION
https://doi.org/10.15690/pf.v10i5.821
Abstract
Study of sensitization spread is crucial to the understanding of formation mechanisms of allergic diseases symptoms and development of prevention programs. However, this parameter has been studied very insufficiently in Russia. The aim of this trial is to study spread of sensitization to allergens and skin sensitivity to histamine in the populations of urban and rural schoolchildren using the method of skin prick test. Methods: the authors examined 2,290 urban and rural schoolchildren (1-11 grades). Mixed allergens of house dust mites, cockroach, fish, birch pollen, mixed weeds and cat hair were used for the allergy test. Results: the authors revealed spread of sensitization to various allergens in various age-sex groups of urban and rural schoolchildren in Tomsk Region. Conclusion: the trial revealed that sensitization spread and skin sensitivity to histamine was higher in urban schoolchildren than in their rural peers (p<0.001). Lower sensitization spread index in rural schoolchildren may be caused the skin reactivity reduction.
About the Authors
E. M. Kamaltynova
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service on Surveillance in Healthcare, Tomsk
Russian Federation
MD, assistant professor of the intermediate level pediatrics department with a course in children’s diseases at the medical faculty of the SibSMU
Russian Federation
MD, assistant professor of the intermediate level pediatrics department with a course in children’s diseases at the medical faculty of the SibSMU
I. A. Deev
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service
on Surveillance in Healthcare, Tomsk, Russian Federation
L. M. Ogorodova
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service
on Surveillance in Healthcare, Tomsk, Russian Federation
E. von Mutsius
Academic Teaching Hospital of the Ludwig Maximilian University, Haunerschen Academic Teaching Hospital of Pediatric Surgery, Munich, Germany
Germany
Germany
S. Illi
Academic Teaching Hospital of the Ludwig Maximilian University, Haunerschen Academic Teaching Hospital of Pediatric Surgery, Munich, Germany
Germany
Germany
M. M. Fedotova
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service
on Surveillance in Healthcare, Tomsk, Russian Federation
Russian Federation
Russian Federation
E. A. Karbainova
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service
on Surveillance in Healthcare, Tomsk, Russian Federation
Russian Federation
Russian Federation
D. S. Afanasyeva
Siberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service
on Surveillance in Healthcare, Tomsk, Russian Federation
Russian Federation
Russian Federation
References
1. Asher M. I., Montefort S., Bjorksten et al. ISAAC Phase Three Study. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino conjunctivitis, and eczema in childhood. ISAAC Phases One and Three repeat muliticountry cross-sectional surveys. Lancet. 2006; 368: 733–743.
2. Johansson S. G., Bieber T., Dahl R. et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J. Allergy Clin. Immunol. 2004; 113 (5): 832–6.
3. Pearce N., Pekkanen J., Beasley R. How much asthma is really attributable to atopy? Thorax. 1999; 54 (3): 268–72.
4. Ronmark E., Bjerg A., Perzanowski M. et al. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J. Allergy Clin. Immunol. 2009; 124 (2): 357–63.
5. Carroll W. D., Lenney W., Child F. et al. Asthma severity and atopy: how clear is the relationship? Arch. Dis. Child. 2006; 91: 405–409.
6. Ronchetti R., Villa M. P., Pagani J. et al. Immediate skin reactivity to histamine and to allergens in cohorts of 9-year-old schoolchildren studied 16 years apart. Clin. Exp. Allergy. 2003; 33: 1232–1237.
7. Bousquet J. et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011; 66: 596–604.
8. Dreborg S., Frew A. Allergen standardisation and skin tests. EAACI 1993 subcommittee on skin tests. Allergy. 1993; 14: 48–82.
9. Namazova-Baranova L. S., Ogorodova L. M., Tomilova A. Yu., Deev I. A. et al. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2009; 6 (3): 59–65.
10. Namazova-Baranova L. S., Antonova E. V., Deev I. A. et al. Epidemiologiya allergicheskikh boleznei. Allergiya u detei: ot teorii — k praktike / pod red. L.S. Namazovoi-Baranovoi [Epidemiology of Allergic Diseases. Allergies in Children: from Theory to Practice. Edited by L.S. Namazova-Baranova]. Moscow, Soyuz pediatrov Rossii, 2010–2011. pp. 166–199.
11. Vink N. M., Postma D. S., Schouten J. P. et al. Gender differences in asthma development and remission during transition through puberty: The Tracking Adolescents’ Individual Lives Survey (TRAILS) study. J. Allergy Clin. Immunol. 2010; 126: 498–504.
12. Busse W. W. The National Institutes of Allergy and Infectious Diseases networks on asthma in inner-city children: An approachto improved care. J. Allergy Clin. Immunol. 2010; 125: 529–37.
13. Weinmayr G., Weiland S. K., Bjorksten B. et al. Atopic Sensitization and the International Variation of Asthma Symptom Prevalence in Children. Am. J. Respir. Crit. Care Med. 2007; 176: 565–574.
14. Viinanen A., Munhbayarlah S., Zevgee T. et al. The protective effect of rural living against atopy in Mongolia. Allergy. 2007; 62: 272–280.
15. Remes S. T., Pekkanen J., Soininen L. et al. Does heredity modify the association between farming and allergy in children? Acta Paediatr. 2002; 91: 1163–1169.
16. Majkowska-Wojciechowska B., Pelka J., Korzon L. et al. Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children. Allergy. 2007; 62: 1044–1050.
17. Celedon J. C., Litonjua A. A., Ryan L. et al. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet. 2002; 360 (9335 № 7): 781–2.
18. Perkin M. R., Strachan D. P. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J. Allergy Clin. Immunol. 2006; 117 (6): 1374–81.
19. von Hertzen L., Laatikainen T., Pitkanen T. et al. Microbial content of drinking water in Finnish and Russian Karelia — implications for atopy prevalence. Allergy. 2007; 62 (3): 288–292.
20. Pekkarinen P. T., von Hertzen L., Laatikainen T. et al. A disparity in the association of asthma, rhinitis, and eczema with allergen-specific IgE between Finnish and Russian Karelia. Allergy. 2007; 62: 281–287.
21. Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin. Exp. Allergy. 2005; 35: 153–159.
22. Flohr C., Quinnell R. J., Britton J. Do helminth parasites protect against atopy and allergic disease? Clinical and Experimental Allergy. 2008; 39: 20–32.
23. Evdokimova T. A., Ogorodova L. M. Pediatriya = Pediatrics. 2005; 6: 12–17.
24. Ogorodova L. M., Freidin M. B., Fedorova O. S. et al. Byulleten' sibirskoi meditsiny = Bulletin of siberian medicine. 2006; 4: 48–52.
25. Ogorodova L. M., Deev I. A., Fedorova O. S. et al. Voprosy sovremennoi pediatrii = Current pediatrics. 2011; 10 (3): 43–47.
26. Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin. Exp. Allergy. 2005; 35: 153–159.
Review
For citations:
Kamaltynova E.M., Deev I.A., Ogorodova L.M., von Mutsius E., Illi S., Fedotova M.M., Karbainova E.A., Afanasyeva D.S. SENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGION. Pediatric pharmacology. 2013;10(5):40-45. https://doi.org/10.15690/pf.v10i5.821
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