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Педиатрическая фармакология

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Кишечная микробиота и аллергия. Про- и пребиотики в профилактике и лечении аллергических заболеваний

https://doi.org/10.15690/pf.v16i1.1999

Полный текст:

Аннотация

Микробиота кишечника является фактором, в значительной степени определяющим здоровье человека. Воздействие на ребенка микробного фактора начинается задолго до рождения, и определенные особенности формирования иммунного ответа и микробиоценоза кишечника дети имеют еще до рождения. Для детей с аллергическими заболеваниями характерно снижение разнообразия кишечной микробиоты в первые месяцы жизни — еще до развития аллергической патологии. Возможности корректировать процесс формирования микробиоты достаточно ограничены, однако показано, что раннее (в течение первых часов жизни) прикладывание к груди, грудное вскармливание в течение как минимум первых 6 мес жизни, использование пребиотиков в составе детских молочных смесей, а также применение пробиотиков с доказанной эффективностью может давать положительные эффекты в отношении профилактики аллергии. В обзоре приведены основные выводы последних метаанализов и согласительных документов международных медицинских сообществ в отношении возможности использования про- и пребиотиков в профилактике и лечении аллергических заболеваний. Несмотря на большой научный и практический интерес к проблеме, авторы метаанализов указывают на недостаточное количество клинических исследований, проведенных с соблюдением принципов доказательной медицины.

Об авторах

С. Г. Макарова
Национальный медицинский исследовательский центр здоровья детей
Россия

Макарова Светлана Геннадиевна, доктор медицинских наук, заведующая отделом профилактической педиатрии

119991, Москва, Ломоносовский пр-т, д. 2/2



Л. С. Намазова-Баранова
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова; Центральная клиническая больница РАН
Россия
Москва


О. А. Ерешко
Национальный медицинский исследовательский центр здоровья детей
Россия
Москва


Д. С. Ясаков
Национальный медицинский исследовательский центр здоровья детей
Россия
Москва


П. Е. Садчиков
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова
Россия
Москва


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Для цитирования:


Макарова С.Г., Намазова-Баранова Л.С., Ерешко О.А., Ясаков Д.С., Садчиков П.Е. Кишечная микробиота и аллергия. Про- и пребиотики в профилактике и лечении аллергических заболеваний. Педиатрическая фармакология. 2019;16(1):7-18. https://doi.org/10.15690/pf.v16i1.1999

For citation:


Makarova S.G., Namazova-Baranova L.S., Ereshko O.A., Yasakov D.S., Sadchikov P.E. Intestinal Microbiota and Allergy. Probiotics and Prebiotics in Prevention and Treatment of Allergic Diseases. Pediatric pharmacology. 2019;16(1):7-18. (In Russ.) https://doi.org/10.15690/pf.v16i1.1999

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