The Prevalence of Chronic Diseases in Children who Have Undergone Critical Periods with A Different Severity of Organ Dysfunction in the Neonatal Period: A Retrospective Cohort Study

It is assumed that the severity of the multiple organ dysfunctions syndrome (MODS) in children who have experienced critical conditions in the neonatal period may influence the prevalence of chronic diseases in the preschool age. The aim of the study was to study the relationship between the severity of organ dysfunction in children who had undergone critical conditions in the neonatal period, and the prevalence of chronic diseases in preschool age. Methods. The study included children with MODS, the severity of which was assessed on the NEOMOD scale (moderate dysfunction ≤4 points, severe ≥5 points). Data on the prevalence of chronic diseases were obtained from the history of the child’s development (form № 112/y), a card for preventive medical examination of a minor (form № 030-PO/y-12), objective examination data, laboratory and instrumental survey methods, examination data by narrow specialists. Results. The study included 198 children, 100 of them with severe manifestations of SPON and 98 with moderate manifestations of SPON. The groups were comparable by sex, age, social factors (age and level of education of parents), place of residence (city/ village). Chronic diseases in preschool age occurred in 54% and 26% of cases, respectively, p<0.001. The most frequent were psychiatric and behavioral disorders: 40% and 16%, p<0.001, including coarse psychomotor development delay (PDD) of 18% and 1%, p <0.001; diseases of the nervous system: 30 and 14%, p=0.010, including cerebral palsy (CP) 25% and 8%, p=0.002; diseases of the eye: 28% and 24%, p=0.517, including amblyopia 8% and 3% of cases, p=0.113, respectively. Disability occurred in 19 (19%) cases in the main group, and in 5 (5%) cases in the comparison group (p=0.003). The conclusion. Severe manifestations of MODS in the neonatal period are associated with a higher frequency of coarse PDD and CP in preschool age than mild manifestations of MODS, severe manifestations of MODS are not associated with an increase in the frequency of pathology of the eye.

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