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Functional Gastrointestinal Disorders in Infants: Long-Tern Consequences and Modern Approaches for Prevention and Treatment

https://doi.org/10.15690/pf.v14i5.1788

Abstract

The article discusses modern ideas about the genesis of the most common variants of functional gastrointestinal disorders (FGID) in infants, and their ability to lead to long-term negative consequences for the health of the child. The article provides data on role of intestinal microbiota in development of FGID in infants and current approaches to prevention and correction using probiotics with proven effectiveness.

 

About the Authors

Evgeniya G. Makarova
Nestle Russia, Moscow
Russian Federation


Sergei E. Ukraintsev
Nestle Russia, Moscow; Nationa l Medical Research Center of Children,s Health, Moscow
Russian Federation


References

1. Drossman DA, Dumitrascu DL. Rome III: New standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis. 2006;15(3):237–241.

2. Drossman DА, Richer JE, Talley N, editors. The functional gastrointestinal disorders. Diagnosis, pathophysiology and treatment. A multinational consensus. Boston: Little, Brown & Co; 1994. 370 p.

3. Бельмер С.В., Гасилина Т.В., Хавкин А.И., Эйберман А.С. Функциональные нарушения органов пищеварения у детей. — М.; 2005. — 36 с. [Bel’mer SV, Gasilina TV, Khavkin AI, Eiberman AS. Funktsional’nye narusheniya organov pishchevareniya u detei. Moscow; 2005. 36 p. (In Russ).]

4. Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol. 2009;6(5):306–314. doi: 10.1038/nrgastro.2009.35.

5. Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuro-endocrine factors and stress. J Psychosom Res. 2002;53(4):865–871. doi: 10.1016/S0022-3999(02)00429-4.

6. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014;146(6):1500–1512. doi: 10.1053/j.gastro.2014.02.037.

7. Хавкин А.И., Жихарева Н.С. Подходы к лечению синдрома раз-драженного кишечника у детей // Вопросы современной педиатрии. — 2004. — Т.3. — №2 — С. 30–34. [Khavkin AI, Zhihareva NS. Different approaches to treatment of irritable bowel syndrome in children. Current pediatrics. 2004;3(2):30–34. (In Russ).]

8. Partty A, Kalliomaki M, Salminen S, Isolauri E. Infant distress and development of functional gastrointestinal disorders in childhood: is there a connection? JAMA Pediatr. 2013;167(10):977–978. doi: 10.1001/jamapediatrics.2013.99.

9. Savino F, Castagno E, Bretto R, et al. A prospective 10-year study on children who had severe infantile colic. Acta Paediatr Suppl. 2005;94(449):129–132. doi: 10.1080/08035320510043691.

10. Romanello S, Spiri D, Marcuzzi E, et al. Association between childhood migraine and history of infantile colic. JAMA. 2013;309(15):1607– 1612. doi: 10.1001/jama.2013.747.

11. Canivet C, Jakobsson I, Hagander B. Infantile colic. Follow-up at four years of age: still more “emotional”. Acta Paediatr. 2000;89(1):13–17. doi: 10.1080/080352500750028988.

12. Rautava P, Lehtonen L, Helenius H, Sillanpaa M. Infantile colic: child and family three years later. Pediatrics. 1995;96(1 Pt 1):43–47.

13. Wolke D, Rizzo P, Woods S. Persistent infant crying and hyperactivity problems in middle childhood. Pediatrics. 2002;109(6):1054– 1060. doi: 10.1542/peds.109.6.1054.

14. Rao MR, Brenner RA, Schisterman EF, et al. Long term cognitive development in children with prolonged crying. Arch Dis Child. 2004;89(11):989–992. doi: 10.1136/adc.2003.039198.

15. Wolke D, Schmid G, Schreier A, Meyer R. Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk: a prospective population study. J Dev Behav Pediatr. 2009;30(3):226–238. doi: 10.1097/DBP.0b013e3181a85973.

16. Brown M, Heine RG, Jordan B. Health and well-being in school-age children following persistent crying in infancy. J Paediatr Child Health. 2009;45(5):254–262. doi: 10.1111/j.1440-1754.2009.01487.x.

17. Сорвачева Т.Н., Пашкевич В.В. Функциональные нарушения ЖКТ у грудных детей: методы коррекции // Лечащий врач. — 2006. — №4 — С. 40–46. [Sorvacheva TN, Pashkevich VV. Funktsional’nye narusheniya ZhKT u grudnykh detei: metody korrektsii. Practitioner. 2006;(4):40–46. (In Russ).]

18. Martin AJ, Pratt N, Kennedy JD, et al. Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics. 2002;109(6):1061–1067. doi: 10.1542/peds.109.6.1061.

19. Loening-Baucke V. Constipation in early childhood: patient characteristics, treatment, and longterm follow up. Gut. 1993;34(10):1400– 1404. doi: 10.1136/gut.34.10.1400.

20. Molloy CA, Manning-Courtney P. Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism. 2003;7(2):165–171. doi: 10.1177/1362361303007002004.

21. Niehus R, Lord C. Early medical history of children with autism spectrum disorders. J Dev Behav Pediatr. 2006;27(2):S120–127. doi: 10.1097/00004703-200604002-00010.

22. Valicenti-McDermott M, McVicar K, Rapin I, et al. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr. 2006;27(2 Suppl):S128–136. doi: 10.1097/00004703-200604002-00011.

23. McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014;133(5):872–883. doi: 10.1542/peds.2013-3995.

24. Foster J, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013;36(5):305– 312. doi: 10.1016/j.tins.2013.01.005.

25. Naseribafrouei A, Hestad K, Avershina E, et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014;26(8):1155–1162. doi: 10.1111/nmo.12378.

26. Mayer EA, Padua D, Tillisch K. Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays. 2014;36(10):933– 939. doi: 10.1002/bies.201400075.

27. Song YL, Liu CX, Finegold SA. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol. 2004;70(11):6459– 6465. doi: 10.1128/Aem.70.11.6459-6465.2004.

28. Simren M, Barbara G, Flint HJ, et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut. 2013;62(1):159–176. doi: 10.1136/gutjnl-2012-302167.

29. Mayer EA, Tillisch K. The brain-gut axis in abdominal pain syndromes. Annu Rev Med. 2011;62:381–396. doi: 10.1146/annurev-med-012309-103958.

30. Berrill JW, Gallacher J, Hood K, et al. An observational study of cognitive function in patients with irritable bowel syndrome and inflammatory bowel disease. Neurogastroenterol Motil. 2013;25(11):918– E704. doi: 10.1111/nmo.12219.

31. Crouzet L, Gaultier E, Del’Homme C, et al. The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota. Neurogastroenterol Motil. 2013;25(4):e272– e282. doi: 10.1111/nmo.12103.

32. Kunze WA, Mao YK, Wang BX, et al. Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J Cell Mol Med. 2009;13(8b):2261–2270. doi: 10.1111/j.1582-4934.2009.00686.x.

33. Iyer LM, Aravind L, Coon SL, et al. Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends Genet. 2004;20(7):292–299. doi: 10.1016/j.tig2004.05.007.

34. Asano Y, Hiramoto T, Nishino R, et al. Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice. Am J Physiol Gastrointest Liver Physiol. 2012;303(11):G1288–1295. doi: 10.1152/ajpgi.00341.2012.

35. Sobko T, Huang LY, Midtvedt T, et al. Generation of NO by probiotic bacteria in the gastrointestinal tract. Free Radic Biol Med. 2006;41(6):985–991. doi: 10.1016/j.freeradbiomed.2006.06.020.

36. Schicho R, Krueger D, Zeller F, et al. Hydrogen sulfide is a novel prosecretory neuromodulator in the guinea-pig and human colon. Gastroenterology. 2006;131(5):1542–1552. doi: 10.1053/j. gastro.2006.08.035.

37. Myint AM, Kim YK. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypotheses. 2003;61(5-6):519–525. doi: 10.1016/S0306-9877(03)00207-X.

38. Appel E, Kolman O, Kazimirsky G, et al. Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli. Neuroreport. 1997;8(15):3309–3312. doi: 10.1097/00001756-199710200-00023.

39. Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry. 2003;54(1):70–75. doi: 10.1016/S0006-3223(03)00181-1.

40. Kimura I, Inoue D, Maeda T, et al. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A. 2011;108(19):8030–8035. doi: 10.1073/pnas.1016088108.

41. Grider JR, Piland BE. The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G429–G437. doi: 10.1152/ajpgi.00376.2006.

42. Vecsey CG, Hawk JD, Lattal KM, et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation. J Neurosci. 2007;27(23):6128– 6140. doi: 10.1523/Jneurosci.0296-07.2007.

43. Stefanko DP, Barrett RM, Ly AR, et al. Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci U S A. 2009;106(23):9447–9452. doi: 10.1073/pnas.0903964106.

44. Gecse K, Roka R, Ferrier L, et al. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity. Gut. 2008;57(5):591–599. doi: 10.1136/gut.2007.140210.

45. Carroll IM, Ringel-Kulka T, Ferrier L, et al. Fecal protease activity is associated with compositional alterations in the intestinal microbiota. PLoS One. 2013;8(10):e78017. doi: 10.1371/journal.pone.0078017.

46. Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology. 2009;136(6):2003–2014. doi: 10.1053/j. gastro.2009.01.075.

47. Theodorou V, Ait Belgnaoui A, Agostini S, Eutamene H. Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. Gut Microbes. 2014;5(3):430–436. doi: 10.4161/ gmic.29796.

48. Uribe A, Alam M, Johansson O, et al. Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat. Gastroenterology. 1994;107(5):1259–1269. doi: 10.1016/0016-5085(94)90526-6.

49. Tortorella C, Neri G, Nussdorfer GG. Galanin in the regulation of the hypothalamic-pituitary-adrenal axis (Review). Int J Mol Med. 2007;19(4):639–647. doi: 10.3892/ijmm.19.4.639.

50. Giordano R, Pellegrino M, Picu A, et al. Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: effects of GABA- , mineralocorticoid-, and GH-Secretagogue-receptor modulation. Scientific World Journal. 2006;6:1–11. doi: 10.1100/ tsw.2006.09.

51. Savino F, Cordisco L, Tarasco V, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics. 2010;126(3):e526–e533. doi: 10.1542/ peds.2010-0433.

52. Indrio F, Riezzo G, Raimondi F, et al. Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants. Eur J Clin Invest. 2011;41(4):417–422. doi: 10.1111/j.1365-2362.2010.02425.x.

53. Coccorullo P, Strisciuglio C, Martinelli M, et al. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. J Pediatr. 2010;157(4):598–602. doi: 10.1016/j.jpeds.2010.04.066.

54. Romano C, Ferrau’ V, Cavataio F, et al. Lactobacillus reuteri in children with functional abdominal pain (FAP). J Paediatr Child Health. 2014;50(10):E68–71. doi: 10.1111/j.1440-1754.2010.01797.x.

55. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: Comparison of two probiotic agents. Pediatrics. 2005;115(1):5–9. doi: 10.1542/peds.2004-1815.

56. Корниенко Е.А., Вагеманс Н.В., Нетребенко О.К. Младенческие кишечные колики: современные представления о механизмах развития и новые возможности терапии // Современная педиатрия. — 2010. — №5 — С. 176–183. [Kornienko EA, Vagemans NV, Netrebenko OK. Infant intestial colics: the modern view about mechanisms of development and new abilities of treatment. Sovremennaya pediatriya. 2010;(5):176–183. (In Russ).]

57. Schaefer L, Auchtung T, Hermans K, et al. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology. 2010;156(Pt 6):1589– 1599. doi: 10.1099/mic.0.035642-0.

58. Нетребенко О.К., Корниенко Е.А., Кубалова С.С. Использование пробиотиков у детей с младенческими коликами // Педиатрия. Журнал имени Г.Н. Сперанского. — 2014. — Т.93. — №4 — С. 86–93. [Netrebenko OK, Kornienko EA, Kubalova SS. Ispol’zovanie probiotikov u detei s mladencheskimi kolikami. Pediatriia. 2014;93(4):86–93. (In Russ).]

59. Valeur N, Engel P, Carbajal N, et al. Colonization and immuno-modulation by Lactobacillus reuteri ATCC 55730 in the human gastrointestinal tract. Appl Environ Microbiol. 2004;70(2):1176–1181. doi: 10.1128/Aem.70.2.1176-1181.2004.

60. Jakobsson T, Abrahamsson T, Blörgsten B, et al. The effect of oral supplementation of Lactobacillus reuteri, on the immunologic composition of breast milk: OP4-05. J Pediatr Gastroenterol Nutr. 2005;40(5):624. doi: 10.1097/00005176-200505000-00042.

61. Gabriela Bergonzelli Degonda (Bussigny), Magali Faure (Forel), Nicole Kusy (Montet). Lactobacillus Reuteri DSM 17938 for the Development of the Enteric Nervous System Patent Application (Application #20140363409); EP20110196138 20111230; Dec 11, 2014.

62. Kamiya T, Wang L, Forsythe P, et al. Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats. Gut. 2006;55(2):191–196. doi: 10.1136/ gut.2005.070987.

63. Savino F, Pelle E, Palumeri E et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007;119(1):e124–130. doi: 10.1542/peds.2006-1222.

64. wpengine.net [Internet]. Cabana MD, Chau K, D’Amico FJ, et al. Is Lactobacillus reuteri DSM 17938 effective for the treatment of infant colic? Results from an International Individual Participant Data Meta-Analysis (IPDMA). Murdoch Childrens Research Institute and The Royal Children’s Hospital Centre for Community Child Health [cited 2017 Aug 29]. Available from: http://4cau4jsaler1zglkq3wnmje1. wpengine.netdna-cdn.com/wp-content/uploads/2016/06/group-1-approved.pdf.

65. Cruchet S, Furnes R, Maruy A, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Pediatric Drugs. 2015;17(3):199–216. doi: 10.1007/s40272-015-0124-6.


Review

For citations:


Makarova E.G., Ukraintsev S.E. Functional Gastrointestinal Disorders in Infants: Long-Tern Consequences and Modern Approaches for Prevention and Treatment. Pediatric pharmacology. 2017;14(5):392-399. (In Russ.) https://doi.org/10.15690/pf.v14i5.1788

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