Metabolic Acidosis: Diagnostics and Treatment
https://doi.org/10.15690/pf.v13i4.1612
Abstract
Metabolic acidosis is the most common child acid-base balance disorder. This condition accompanies a variety of diseases, and the degree of its severity correlates with the patients’ survival: although not a separate disease in itself, metabolic acidosis, however, can worsen the disease course and even lead to death. The pathology causes are various (in connection with life-threatening changes in various organs and systems — lungs, heart and blood vessels, kidneys, and also due to a violation of lipid metabolism, in case of diabetes, poisoning, etc.), which determines the fact that a wide range of specialists are interested in the issue. Approaches to the diagnosis simplify the search for the etiology of metabolic acidosis. This study presents data on the physiological basis of acid-base balance regulation, and its etiology and pathophysiology; the principles of therapy are observed.
About the Authors
R. F. Tepaev
Scientific Center of Children’s Health;
Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
V. V. Lastovka
Scientific Center of Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Pytal
Scientific Center of Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
J. V. Savluk
Scientific Center of Children’s Health
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Jung B, Rimmele T, Le Goff C, et al. Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study. Crit Care. 2011;15(5):R238. doi: 10.1186/cc10487.
2. Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6(5):274–285. doi: 10.1038/nrneph.2010.33.
3. Алипов Н.Н. Основы медицинской физиологии. 2-е изд. — М.: Практика; 2012. — 496 с. [Alipov NN. Osnovy meditsinskoi fiziologii. 2nd ed. Moscow: Praktika; 2012. 496 p. (In Russ).]
4. belmapo.by [интернет]. Сапотницкий А.В., Шишко Г.А., Устинович Ю.А. Новые подходы к диагностике причин метаболического ацидоза в интенсивной терапии новорожденных: анионный промежуток плазмы крови. [Sapotnitsky AV, Shishko GA, Ustinovich YA. New approaches to the diagnosis of the causes metabolic acidosis in the neonatal intensive care: anion gap. (In Russ).] Доступно по: http://belmapo.by/downloads/neonatalogii/2013/novie_podhodi.pdf. Доступ на 16.07.2016.
5. Гайтон А.К. Медицинская физиология. Пер. с англ / Под ред. В.И. Кобрина. — М.: Логосфера; 2008. — 1296 с. [Gaiton AK. Meditsinskaya fiziologiya. Transl. from English. Ed by V.I. Kobrin. Moscow: Logosfera; 2008. 1296 p. (In Russ).]
6. Hatherill M, Waggie Z, Purves L, et al. Mortality and the nature of metabolic acidosis in children with shock. Intensive Care Med. 2003;29(2):286–291. doi: 10.1007/s00134-002-1585-y.
7. medscape.com [Internet]. Christie PT. Metabolic acidosis [cited 2016 Jul 16]. Available from: http://emedicine.medscape.com/article/242975-overview#a6.
8. AJKDblog [Internet]. Emmett M. An unexpected gap effects of salicylates and other conditions on the serum anion gap [updated 2015 Nov 25; cited 2016 Jul 16]. Available from: http://ajkdblog.org/2015/11/23/an-unexpected-gap-effects-of-salicylates-and-otherconditions-on-the-serum-anion-gap/.
9. Barry P, Morris K, Ali T. Oxford specialist handbooks in pediatrics series. Oxford: Oxford University Press; 2010. 896 p.
10. medscape.com [Internet]. Huang LH, Corden TE, Priestley MA. Pediatric metabolic acidosis [cited 2016 Jul 16]. Available from: http://emedicine.medscape.com/article/906819-overview.
11. Khajuria A, Krahn J. Osmolality revisited--deriving and valida ting the best formula for calculated osmolality. Clin Biochem. 2005;38(6):514–519. doi: 10.1016/j.clinbiochem.2005.03.001.
12. medscape.com [Internet]. Gunnerson KJ. Lactic acidosis [cited 2016 Jul 16]. Available from: http://emedicine.medscape.com/article/167027-overview.
13. uchc.edu [Internet]. Graham T. Acid base online tutorial. Case 3 [cited 2016 Jul 17]. Available from: http://fitsweb.uchc.edu/student/selectives/TimurGraham/Case_3.html.
14. Charles JC, Heilman RL. Metabolic acidosis. Clinical review article. Hospital Physician [Internet]. 2005 [cited 2016 Jul 16];(3): 37-42. Available from: http://www.turner-white.com/memberfile.php?PubCode=hp_mar05_acid.pdf. (16.07.2016)
15. Fuhrman BP, Zimmerman JJ, editors. Pediatric critical care. 3rd ed. Philadelphia; 2006. 976 p.
16. Зильбер А.П. Этюды критической медицины. Книга I. Медицина критических состояний. — Петрозаводск: Изд-во Петрозаводского университета; 1995. 360 с. [Zil’ber AP. Etyudy kriticheskoi meditsiny. Kniga I. Meditsina kriticheskikh sostoyanii. Petrozavodsk: Izd-vo Petrozavodskogo universiteta; 1995. 360 p. (In Russ).]
Review
For citations:
Tepaev R.F., Lastovka V.V., Pytal A.V., Savluk J.V. Metabolic Acidosis: Diagnostics and Treatment. Pediatric pharmacology. 2016;13(4):384-389. (In Russ.) https://doi.org/10.15690/pf.v13i4.1612
Views:
24895
Email this article 