The Efficacy of Preventing Rachitis in Babies by Using Vitamin D Solutio Oleosa: the Results of a Short-Term Comparative Investigation

Background: Vitamin D-deficient states remain highly prevalent in children, according to Russian and foreign studies. Because of this, it is important to conduct timely prevention of rachitis in children, taking into account the commitment to therapy from the parents’ side.

Objective: Our aim was to study the preventive efficacy of the Russian-manufactured vitamin D3 solutio oleosa with regard to preventing rachitis.

Methods: A short-term prospective comparative study has been conducted. Vitamin D3 was used in the dosages of 400 and 800 ME or 500 and 1000 ME, in the form of an oil or water solution of cholecalciferol in mature and premature (according to the gestation term) children, correspondingly. The control group was comprised of mature children of a comparable age, who received no vitaminoprophilaxis (parental refusal). We evaluate clinical symptoms of rachitis before and after 1 month after the beginning of the study.

Results: 111 children aged 4–6 months, of them 66 mature and 45 premature were included into the study. None of the children developed rachitis symptoms while taking vitamin D3 while 8 out of 15 controls (53%) developed signs of rachitis.

Conclusion: We demonstrated a comparative efficacy of oil and water solutions of vitamin D3 with regard to preventing rachitis in mature and premature children.

1. Yu C, Fedoric B, Anderson PH, Lopez AF, Grimbaldeston MA. Vitamin D (3) signalling to mast cells: A new regulatory axis. Int J Biochem Cell Biol. 2011;43(1):41–46. doi: 10.1016/ j.biocel.2010.10.011.

2. Lucas Robyn M, Gorman Sh, Geldenhuys S, Hart Prue H. Vitamin D and immunity. F1000Prime Reports. 2014;6:118. doi: 10.12703/p6-118.

3. Norman AW, Henry HH. Vitamin D. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition, 9th ed. Washington DC: ILSI Press; 2006.

4. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. МР 2.3.1.2432-08. М., 2008. [Normy fiziologicheskikh potrebnostei v energii i pishchevykh veshchestvakh dlya razlichnykh grupp naseleniya Rossiiskoi Federatsii. MR 2.3.1.2432-08. Moscow; 2008. (In Russ).]

5. Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGrath JJ, et al. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr. 2007;85(3):649–650. Erratum in: Am J Clin Nutr. 2007;86(3):809.

6. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3): 266–81. doi: 10.1056/nejmra070553.

7. Захарова И. Н., Мальцев С. В., Боровик Т. Э., Яцык Г. В., Малявская С. И., Вахлова И. В., Шуматова Т. А., Романцова Е. Б., Романюк Ф. П., Климов Л. Я., Пирожкова Н. И., Колесникова С. М., Курьяникова В. А., Творогова Т. М., Васильева С. В., Мозжу хина М. В., Евсеева Е. А. Недостаточность витамина D у детей раннего возраста в России: результаты многоцентрового когортного иследования РОДНИЧОК (2013–2014 гг.) // Вопросы современной педиатрии. — 2014. — Т. 13. — № 6 — С. 30–34. [Zakharova IN, Mal’tsev SV, Borovik ТE, et al. Vitamin D insufficiency in children of tender years in Russia: the results of a multicentre cohort study Rodnichok (2013–2014). Current pediatrics. 2014;13(6):30–34. (In Russ).] doi: 10.15690/vsp.v13i6.1198.

8. Национальная программа оптимизации вскармливания детей первого года жизни в Российской Федерации. Москва, 2011. [Natsional’naya programma optimizatsii vskarmlivaniya detei pervogo goda zhizni v Rossiiskoi Federatsii. Moscow; 2011. (In Russ).]

9. d3vit.ru [интернет]. Инструкция по применению биологически активной добавки к пище Д3 Вит беби [доступ от 21.06.2016]. [Instruktsiya po primeneniyu biologicheski aktivnoi dobavki k pishche D3 Vit bebi. (In Russ).] Доступ по ссылке http://d3vit.ru/instruktsiya.

10. Яцык Г. В., Беляева И. А., Шатская С. Ю. Применение витамина D при рахите у недоношенных детей // Российский педиатрический журнал. — 2013. — № 5 — С. 45– 49. [Yatsyk GV, Belyaeva IA, Shatskaya SYu. Exchange of vitamin D and features rickets in premature infants. Rossiiskii pediatricheskii zhurnal. 2013;(5):45–49. (In Russ).]

11. Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy. 2012; 67 (3):296–301. doi: 10.1111/j.1398-9995.2011.02755.x.