Preview

Pediatric pharmacology

Advanced search

THERAPY OF ACUTE RESPIRATORY INFECTIONS IN CHILDREN: NOVELTIES

https://doi.org/10.15690/pf.v11i1.892

Abstract

The article is dedicated to acute respiratory infections — the most frequent cause of visits to doctors all around the world, especially among children under 5 years of age. The authors cite data on clinical ARI course variants in small children, present data of virologic analysis and immune status peculiarities, list the main methods of ARI prevention in children and assess efficacy of using bacterial lysates in children with acute and recurrent acute respiratory diseases.

 

About the Authors

I. N. Zakharova
Russian Medical Academy of Postgraduate Education of the RF MH (Ministry of Health), Moscow
Russian Federation
PhD, Professor, head of the department of pediatrics of the Russian Medical Academy of Postgraduate Education (State Budgetary Educational Institution) of the RF MH (Ministry of Health), Honored Doctor of the Russian Federation


A. N. Goryaynova
Russian Medical Postgraduate Academy of the RF MH (Ministry of Health), Moscow
Russian Federation


N. V. Koroid
Tushino Children’s Municipal Hospital of Moscow, Russian Federation
Russian Federation


L. B. Torshkhoyeva
Russian Medical Postgraduate Academy of the RF MH (Ministry of Health), Moscow
Russian Federation


I. B. Lagadze
Russian Medical Postgraduate Academy of the RF MH (Ministry of Health), Moscow
Russian Federation


References

1. Garibaldi R. A. Epidemiology of community-acquired respiratory tract infections in adults. Incidence, etiology, and impact. Am. J. Med. 1985 Jun 28;78 (6B): 32–37.

2. Fendrick A. M., Monto A. S., Nightengale B., Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch. Intern. Med. 2003 Feb 24; 163 (4): 487–494.

3. Zakharova I.N., Cheburkin A.V., Malinovskaya V.V. et al. Importance of interferon system for immune response formation in children with acute respiratory viral infections. Voprosy prakticheskoi pediatrii = Problems of practical pediatrics. 2009; 4 (5): 38–45.

4. Zakharova I. N., Malinovskaya V. V., Torshkhoeva L. B. Clinical-immunological efficacy of using a drug based on recombinant IFN-A2 Viferon (suppositories and ointment) for treating acute respiratory infections in small children. Pediatriya = Pediatrics. 2011; 4: 28.

5. Zakharova I.N., Malinovskaya V.V., Korovina N.A. et al. Clinical-immunological substantiation of local interferon therapy for respiratory viral infections in children. Voprosy prakticheskoi pediatrii = Problems of practical pediatrics.2011; 6 (5): 21–26.

6. Zakharova I.N., Torshkhoeva L.B., Zaplatnikov A.L. et al. Interferon system peculiarities at acute respiratory infections and clinical-immunological efficacy of modified interferon therapy in small children. Efficient pharmacotherapy. Pediatriya = Pediatrics. 2011; 1: 70.

7. Zakharova I.N., Torshkhoeva L.B., Zaplatnikov A.L. et al. Modified interferon therapy for acute respiratory infections in small children: pathogenetic substantiation and efficacy. Rossiiskii vestnik perinatologii i pediatrii = Russian bulletin of perinatology and pediatrics. 2011; 56 (3): 49–54.

8. Nelson Essentials of Pediatrics (6th ed.). 2011. 831 p.

9. Malinovskaya V.V., Zakharova I.N., Isaeva E.I. et al. Etiological structure of acute respiratory infections in small children. Voprosy prakticheskoi pediatrii = Problems of practical pediatrics. 2010; 5 (5): 99–104.

10. Botvin'eva V.V., Aref'eva N.A., Aznabaeva L.F., Ivanova R.A., Romantsov M.G. Respiratornye zabolevaniya: etiopatogenez, klinika, lechenie, profilaktika. Rukovodstvo dlya vrachei [Respiratory Diseases: Etiopathogenesis, Clinical Pattern, Treatment, Prevention. Guidelines]. St. Petersburg, 2002. 48 p.

11. Shvets E.Yu. Kliniko-epidemiologicheskie osobennosti i diagnostika bokavirusnoi infektsii u detei. Avtoref. dis. … kand. med. nauk [Clinical and Epidemiological Peculiarities and Bocavirus Infection Diagnostics in Children. Author’s abstract]. Moscow, 2009. 24 p.

12. Kozulina I.S., Samsygina G.A., Isaeva E.I., Legkova T.P., Shevchenko I.M., Donin I.M., Pavlov S.A. Metapneumovirus infection in children. Pediatriya = Pediatrics. 2009; 88 (5): 58–62.

13. Braido F., Tarantini F., Ghiglione V., Melioli G., Canonica G.W. Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections. International Journal of COPD. 2007; 2 (3): 335–345.

14. Sramek J., Josifko M., Helcl J., Holoubkova E., Janout V., Kozesnik B., Macatova I. Bacterial lysate (I.R.S. 19) applied intranasally in the prevention of acute respiratory diseases in children: a randomized double-blind study. J. Hyg. Epidemiol. Microbiol. Immunol. 1986; 30 (4): 377–385.

15. Binder P., Gendre F., Huart B., Paucod J.C., Deschaux P., Fontan ges R. Immunomodulation in offspring mice after neonatal immunostimulation of mothers or newborn mice. Tohoku J. Exp. Med. 1985 Aug; 146 (4): 379–383.

16. Razi C., Harmanci K., Abaci A., Ozdemir O., Hizli S., Renda R., Keskin F. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J. Allergy Clin. Immunol. 2010; 126: 763–769.

17. Schaad U., Mutterlein R., Goffin H. BV-child study group. Immunostimulation with OM-85 in children with acute recurrent infections of the upper respiratory tract. Chest. 2002; 122: 2042–2049.

18. Gutierrez-Tarango M., Berber A. Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months. Chest. 2001; 119: 1742–1748.

19. Schaad U. Prevention of paediatric respiratory tract infections: emphasis on the role of OM-85. Eur. Respir. Rev. 2005; 14: 74–77.

20. Maestroni G., Losa G. Clinical and immunobiological effects of an orally administered bacterial extract. Int. J. Immunopharmacol. 1984; 6: 111–117.

21. Berber A., Del-Rio-Navarro B. Use of Broncho-Vaxom in private practice: phase IV trial in 587 children. Clin. Ther. 1996 Nov-Dec; 18 (6): 1068–1079.

22. Emmerich B., Emslander H., Milatovic D., Hallek M., Pachmann K. Effects of a bacterial extract on local immunity of the lung in patients with chronic bronchitis. Respiration. 1990; 57 (2): 90–99.

23. Soler M., Mutterlein R., Cozma G. Double-Blind Study of OM-85 in Patients with Chronic Bronchitis or Mild Chronic Obstructive Pulmonary Disease. Respiration. 2007; 74: 26–32.

24. Carmona-Ramirez M., Alvarez-Gomez V., Berber A. Use of OM-85 BV for the Prevention of Acute Respiratory Tract Infections in Occupational Medicine. The Journal of International Medical Research. 2002; 30: 325–329.

25. Navarro S., Cossalter G., Chiavaroli C., Kanda A., Fleury S., Lazzari A., Cazareth J., Sparwasser T., Dombrowicz D., Glaichenhaus N., Julia V. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunology. 2011; 4 (1): 53–65.

26. Steurer-Stey C., Bachmann L., Steurer J., Tramer M. R. Oral purified bacterial extracts in chronic bronchitis and COPD: systematic review. Chest. 2004 Nov; 126 (5): 1645–55.

27. Jonston S., Pattermore P., Sanderson G., Smith S., Lampe F., Josephs S. et al. Role of virus infections in exacerbations in children with recurrent wheeze or cough. Thorax. 1993; 48: 1055.

28. Jonston S., Pattermore P., Sanderson G., Smith S, Lampe F., Josephs L., Symington P., O'Toole S., Myint S.H., Tyrrell D.A. et al. Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ. 1995; 310: 1225–9.

29. Pessey J. J., Megas F., Arnould B., Baron-Papillon F. Prevention of recurrent rhinopharyngitis in at-risk children in France: a costeffectiveness model for a nonspecific immunostimulating bacterial extract (OM-85 BV). Pharmacoeconomics. 2003; 21 (14): 1053–1068.


Review

For citations:


Zakharova I.N., Goryaynova A.N., Koroid N.V., Torshkhoyeva L.B., Lagadze I.B. THERAPY OF ACUTE RESPIRATORY INFECTIONS IN CHILDREN: NOVELTIES. Pediatric pharmacology. 2014;11(1):31-36. https://doi.org/10.15690/pf.v11i1.892

Views: 757


ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)