Preview

Pediatric pharmacology

Advanced search

MAGNESIUM DEFICIT AS A MODERN NUTRITIONAL ISSUE IN CHILDREN AND ADOLESCENTS

https://doi.org/10.15690/pf.v11i1.891

Abstract

The review is dedicated to the issues of body magnesium deficit. The authors used data of the evidence-based trials. The authors consider pathologic conditions predisposed by magnesium deficit, i.e. excess weight and obesity, attention deficit and hyperactivity disorder, impaired glucose intolerance, arterial hypertension, gallstone disease and other conditions in detail. The authors dwell upon ways of magnesium deficit correction. The article shows that the most effective method is application of organic magnesium salts (lactate, pidolate, citrate).

 

About the Author

O. Alekseevna Gromova
http://www.isma.ivanovo.ru/divisions/65/posts/172
Russian Satellite Centre of Trace Element — Institute for UNESCO, Moscow Ivanovo State Medical Academy
Russian Federation
PhD, Professor of the department of clinical pharmacology of the Ivanovo State Medical Academy, academic advisor the Russian Satellite Centre of Trace Element — Institute for UNESCO


References

1. Vorontsov I.M. Aktovaya rech' v chest' 80-letiya Sankt-Peterburgskoi pediatricheskoi akademii [Commencement Address Dedicated to the 80th Anniversary of St. Petersburg Pediatric Academy]. Moscow, M-Praktika, 2007.

2. Torshin I.Yu., Gromova O. A. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science, 2011. 250 p. ISBN-10:1-60741-704-709.

3. Svyatova N.V., Sitdikov F.G., Egerev E.S., Kosov A.V., Gainullin A.A. Magnesium effect on a child’s body. Fundamental'nye issledovaniya = Fundamental research. 2013; 8: 7–9.

4. Shibata T., Murakami T., Nakagaki H., Narita N., Goshima M., Sugiyama T., Nishimuta M. Calcium, magnesium, potassium and sodium intakes in Japanese children aged 3 to 5 years. Asia Pac. J. Clin. Nutr. 2008; 17 (3): 441–445.

5. Ozmen H., Akarsu S., Polat F., Cukurovali A. The levels of calcium and magnesium, and of selected trace elements, in whole blood and scalp hair of children with growth retardation. Iran J. Pediatr. 2013 Apr; 23 (2): 125–130.

6. Morales-Ruan Mdel C., Villalpando S., Garcia-Guerra A., Shamah- Levy T., Robledo-Perez R., Avila-Arcos M. A., Rivera J. A. Iron, zinc, copper and magnesium nutritional status in Mexican children aged 1 to 11 years. Salud Publica Mex. 2012 Mar-Apr; 54 (2): 125–134.

7. De la Cruz-Gongora V., Gaona B., Villalpando S., Shamah-Levy T., Robledo R. Anemia and iron, zinc, copper and magnesium deficiency in Mexican adolescents: National Health and Nutrition Survey 2006. Salud Publica Mex. 2012 Mar-Apr; 54 (2): 135–145.

8. Gromova O.A. Mikronutrienty v oftal'mologii [Micronutrients in Ophthalmology]. DSM, 2008. 110 p.

9. Afridi H. I., Kazi T. G., Kazi N., Kandhro G. A., Baig J. A., Shah A. Q., Khan S., Kolachi N. F., Wadhwa S. K., Shah F. Evaluation of status of calcium, magnesium, potassium, and sodium levels in biological samples in children of different age groups with normal vision and night blindness. Clin. Lab. 2011; 57 (7–8): 559–574.

10. Sahin G., Ertem U., Duru F., Birgen D., Yuksek N. High prevelance of chronic magnesium deficiency in T cell lymphoblastic leukemia and chronic zinc deficiency in children with acute lymphoblastic leukemia and malignant lymphoma. Leuk Lymphoma. 2000 Nov; 39 (5–6): 555–562.

11. Vanaelst B., Huybrechts I., Michels N., Florez M. R., Aramendia M., Balcaen L., Resano M., Vanhaecke F., Bammann K. Hair minerals and metabolic health in Belgian elementary school girls. Biol. Trace Elem. Res. 2013 Mar; 151 (3): 335–343.

12. Fulgoni V. L., Quann E. E. National trends in beverage consumption in children from birth to 5 years: analysis of NHANES across three decades. Nutr. J. 2012 Oct 31; 11: 92.

13. Celik N., Andiran N., Yilmaz A. E. The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. J. Pediatr. Endocrinol. Metab. 2011; 24 (9–10): 675–678.

14. Evangelopoulos A. A., Vallianou N. G., Panagiotakos D. B., Georgiou A., Zacharias G. A., Alevra A. N., Zalokosta G. J., Vogiatzakis E. D., Avgerinos P. C. An inverse relationship between cumulating components of the metabolic syndrome and serum magnesium levels. Nutr. Res. 2008; 28 (10): 659–663.

15. Jose B., Jain V., Vikram N. K., Agarwala A., Saini S. Serum Magnesium in Overweight Children. Indian Pediatr. 2011. Indian Ped: S097475591100061-S.

16. Huerta M. G., Roemmich J. N., Kington M. L., Bovbjerg V. E., Weltman A. L., Holmes V. F., Patrie J. T., Rogol A. D., Nadler J. L. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 2005; 28 (5): 1175–1181.

17. Gromova O.A. Magnii i piridoksin: osnovy znanii [Magnesium and Pyridoxine: Basics]. Moscow, ProtoTip, 2006. 234 p.

18. Gromova O.A. Elementnyi status i sposoby ego korrektsii u detei s razlichnymi iskhodami perinatal'noi entsefalopatii. Avtoref. dis. … dokt. med. nauk [Elemental Status and Means of Correcting thereof in Children with Various Perinatal Encephalopathy Outcomes. Author’s abstract]. 2001. 47 p.

19. Schreier B., Hocker B. Engineering the enolase magnesium II binding site: implications for its evolution. Biochemistry. 2010; 49: 7582–7589.

20. Kim K. H., Ishizaki N., Iguchi E., Funaba M., Matsui T. Effect of Magnesium Deficiency on Various Mineral Concentrations in Rat Liver. Biol. Trace Elem. Res. 2011. С. 335–338.

21. Tsai C. J., Leitzmann M. F., Willett W. C., Giovannucci E. L. Longterm effect of magnesium consumption on the risk of symptomatic gallstone disease among men. Am. J. Gastroenterol. 2008; 103 (2): 375–382.

22. Inoue I. Lipid metabolism and magnesium. Clin. Calcium. 2005; 15 (11): 65–76.

23. Rosanoff A., Seelig M. S. Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals. J. Am. Coll Nutr. 2004; 23 (5): 501–505.

24. Fujii H. Nuclear Receptor PPARs and magnesium. Clin. Calcium. 2005; 15 (11): 52–64.

25. Blinov D.V. Objective methods of severity determination and prognosis of perinatal hypoxic-ischemic CNS lesion prognosis. Akusherstvo, ginekologiya i reproduktsiya = Obstetrics, gynecology and reproduction. 2011; 2: 5–12.

26. Qina J., Chaia G., Brewerb J. M., Lovelacea L. L., Lebiodaa L. Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunits interaction and inhibitors cooperativity. J. Inorg Biochem. 2012 June; 111: 187–194.

27. Ogoma Y., Kobayashi H., Fujii T., Kondo Y., Hachimori A., Shimizu T., Hatano M. Binding study of metal ions to S100 protein: 43Ca, 25Mg, 67Zn and 39K n.m.r. Int. J. Biol. Macromol. 1992; 14 (5): 279–286.

28. McCann D., Barrett A., Cooper A., Crumpler D., Dalen L., Grimshaw K., Kitchin E., Lok K., Porteous L., Prince E., Sonuga-Barke E., Warner J. O., Stevenson J. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet. 2007; 370 (9598): 1560–1567.

29. Gansler D. A., Fucetola R., Krengel M., Stetson S., Zimering R., Makary C. Are there cognitive subtypes in adult attention deficit/hyperactivity disorder? J. Nerv Ment Dis. 1998 Dec; 186 (12): 776–781.

30. Starobrat-Hermelin B. The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders. Article in Polish Ann. Acad. Med. Stetin. 1998; 44: 297–314.

31. Gromova O.A., Torshin I.Yu., Kalacheva A.G., Zhidomorov N.Yu., Grishina T.R., Volkov A.Yu., Glagovskii P.B., Nazarenko O.A., Sadin A.V., Satarina T.E., Yurgel' I.S. Blood magnesium concentration dynamics after intake of various magnesium-containing preparations. Farmateka = Pharmateca. 2009; 10: 63–68.

32. Torshin I.Yu., Gromova O.A. Dvadtsat' pyat' mgnovenii molekulyarnoi farmakologii [Twenty-five Moments of Molecular Pharmacology]. Moscow, A Grif, 2013. 674 p.


Review

For citations:


Gromova O.A. MAGNESIUM DEFICIT AS A MODERN NUTRITIONAL ISSUE IN CHILDREN AND ADOLESCENTS. Pediatric pharmacology. 2014;11(1):20-30. https://doi.org/10.15690/pf.v11i1.891

Views: 1338


ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)