PENDING ISSUES OF PATHOGENESIS IN CHILDREN’S INFLAMMATORY INTESTINAL DISEASES. THE ROLE OF INTESTINAL PARIETAL MICROFLORA

Abstract

Inflammatory intestinal diseases are among the critical issues in modern pediatrics. The article discusses the specific nature of genetic predisposition and immune mechanisms of this pathology, as well as the impact of intestinal microflora on the development and evolution of inflammatory intestinal diseases in children. It outlines current views on pathogenesis of Crohn’s disease and non-specific ulcerative colitis. It describes in detail the local immune system functioning mechanism of the digestive tract system and functions of its individual components. It explains the phenomenon of food tolerance. It demonstrates the results of modern research and further problem study prospects.
Key words: inflammatory intestinal diseases, non-specific ulcerative colitis, Crohn’s disease, pathogenesis, intestinal microflora, children.

(Pediatric Pharmacology. – 2010; 7(5):54-58)