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STEVENS-JOHNSON SYNDROME — TOXIC EPIDERMAL NECTROLYSIS IN CHILDREN. PART I. DETERMINATION, ETIOLOGY, PATHOGENESIS, CLINICAL MANIFESTATIONS, SYSTEMIC TREATMENT

Abstract

Part I of the literature review provides modern terminology and classification of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which is now considered different ways of treating the single pathological process induced in children by infections, drugs, malignant and autoimmune diseases. It illustrates in detail the latest data on pathogenesis, describes clinical manifestations of both scenarios and their transition forms. Special emphasis is made on the organisation of care for patients with SJS and TEN. It details various aspects of systemic therapy.
Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, systemic treatment, children.

About the Authors

V.F. Zhernosek
State Educational Institute Belorussian Medical Post-Graduate Academy, Minsk
Belarus
 


T.P. Dyubkova
SEI Belorussian State University, Minsk
Belarus


Review

For citations:


Zhernosek V., Dyubkova T. STEVENS-JOHNSON SYNDROME — TOXIC EPIDERMAL NECTROLYSIS IN CHILDREN. PART I. DETERMINATION, ETIOLOGY, PATHOGENESIS, CLINICAL MANIFESTATIONS, SYSTEMIC TREATMENT. Pediatric pharmacology. 2011;8(1):30-38.

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ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)