DIAGNOSTICS OF GLOMERULAR CAUSES OF HEMATURIA IN CHILDREN
https://doi.org/10.15690/pf.v9i3.321
Abstract
Hematuria is a significant manifestation, which can reflect both renal disorders and other urinary tract diseases and also be a symptom of systemic illnesses. High prevalence, diversity of etiological and trigger factors, latent course of hematuria and phenotypic resemblance of a number of underlying nephropathies symptoms cause increased interest and urgency of further investigations of such diseases features. The examination of 56 children showed that the most common cause of glomerular hematuria was hereditary kidney diseases, associated with collagen IV type mutations — 64% (Alport syndrome — 56%, thin basement membrane disease — 44%) and IgA-nephropathy — 36%. Comparative analysis of these conditions is presented in this study.
About the Authors
A. P. Potemkina
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
T. V. Margieva
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
O. V. Komarova
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
P. E. Povilaitite
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
L. V. Leonova
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
T. V. Vashurina
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
O. I. Zrobok
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
A. N. Tsygin
Scientific Centre of Children’s Health RAMS, Moscow
Russian Federation
Russian Federation
References
1. Борисов В. В., Вашурина Т. В., Вознесенская Т. С. и др. Нефрология: национальное руководство / под ред. Н. А. Мухина. М.: ГЭОТАР-Медиа. 2009. С. 112–118.
2. Лойманн Э., Цыгин А. Н., Саркисян А. А. Практическое руководство. Детская нефрология. Москва: Литтерра. 2010. С. 84–85, 172–178.
3. Cameron J. S. The patient with proteinuria and/or haematuria. In: Oxford textbook of Clinikal nephrology, 2-nd ed. Oxford University, Press London. 1998. Р. 441–455.
4. Wilcox C. S., Berl T., Himmelfarb J. et al. Therapy in nephrology and hypertension: a companion to Brenner and Rector's. The kidney. 2008 P. 503–507.
5. Комарова О. В., Маргиева Т. В., Цыгин А. Н. Синдром гематурии у детей. Вопросы диагностики в современной педиатрии. 2009; 1 (4): 28–31.
6. Комарова О. В. Синдром гематурии у детей. Медицинский научный и учебно-методический журнал. 2006; 30.
7. Geary D. F., Schaefer F. Comprehensive Pediatric Nephrology. Philadelphia: Mosby. 2008. Р. 179–184, 229–235.
8. Roth S., Renner E., Rathert P. Microscopic hematuria: advances in identification of glomerular dysmorphic erythrocytes. J Urol. 1991; 146 (3): 680–684.
9. Приходина Л. С., Малашина О. А. Современные представления о гематурии у детей. Нефрология и диализ. 2000; 3: 42–49.
10. Сергеева Т. В., Дмитриенко С. В., Цыгин А. Н. Синдром гематурии у детей. Качество жизни. 2006; 4 (15): 68–71.
11. Bohler W. J., Luft F. C. et al. Nephrologie. Pathologie-KlinikNierenersetzverfahren. Thieme-Stuttgart. 2008. Р. 12.
12. Zaman Z., Proesmans W. Dysmorphic erythrocytes and G1 cells as markers of glomerular hematuria. Pediatric. Nephrology. 2000; 14: 980–984.
13. Gubler M. C. Inherited diseases of the glomerular basement membrane. Nat Clin Pract Nephrol. 2008; 4 (1): 24–37.
14. Jedlicka J. N. Die interstitielle entzundung im rahmen des alport syndroms. Munchen-Pasing. 2011. Р. 74.
15. D'Amico G. Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis. 2000; 36 (2): 227–237.
16. Tumlin J. A., Madaio M. P., Hennigar R. Idiopathic IgA nephropathy: pathogenesis, histopathology and therapeutic options. CJASN. 2007; 2 (5): 1054–1061.
17. Schroder C. H., Bontemps C. M., Assmann J. M. et al. Renal biopsy and family studies in 65 children with isolated hematuria. Acta Paediatrica. 1990; 79 (6–7): 630–636.
18. Игнатова М. С. Гематурия при наследственных нефропатиях. Нефрология и диализ. 2006; 4: 64–71.
19. Jais J., Knebelmann B., Giatras I. et al. X-linked alport syndrome: natural history and genotype-phenotype correlation in girls and women belonging to 195 families: A «European community alport syndrome concerted action» study. J Am Soc Nephrol. 2003; 14: 2603–2610.
Review
For citations:
Potemkina A.P., Margieva T.V., Komarova O.V., Povilaitite P.E., Leonova L.V., Vashurina T.V., Zrobok O.I., Tsygin A.N. DIAGNOSTICS OF GLOMERULAR CAUSES OF HEMATURIA IN CHILDREN. Pediatric pharmacology. 2012;9(3):46-51. (In Russ.) https://doi.org/10.15690/pf.v9i3.321
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