Preview

Pediatric pharmacology

Advanced search

Curcumin as a Novel Trend in Adjunctive Therapy for Ulcerative Colitis

https://doi.org/10.15690/pf.v21i6.2840

Abstract

Management of ulcerative colitis remains challenging. The search of new treatment approaches for this disease is constantly continuing. In recent years, the focus was changed to curcumin, active polyphenol found in turmeric roots, that has numerous positive effects on the human body such as anti-inflammatory, anti-carcinogenic, and antioxidant features. Curcumin affects several signaling cellular pathways and gut microbiota content. This review summarizes modern data on the curcumin potential use in ulcerative colitis management.

About the Authors

Anatoly I. Khavkin
Research and Clinical institute for Children; Beigorod State University
Russian Federation

Anatoly I. Khavkin, MD, PhD, Professor 

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

 


Disclosure of interest:

Not declared



Andrew V. Naiyotov
Donetsk State iVledicai University named after iVI. Gorky
Russian Federation

Andrew V. Nalyotov, MD, PhD, Professor

Donetsk

 


Disclosure of interest:

Not declared



References

1. Khavkin AI, Nalyotov AV, Marchenko NA. Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2023;33(6):7–15. (In Russ). https://doi.org/10.22416/1382-4376-2023-33-6-7-15

2. Khavkin AI, Nalyotov AV, Fedulova EN, Marchenko NA. Inflammatory bowel diseases in children: diagnostic algorithms and modern therapy strategies. Voprosy dietologii = Nutrition. 2023;13(3):32–42. (In Russ). https://doi.org/10.20953/2224-5448-2023-3-32-42

3. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet. 2017;390(10114):2769–2778. https://doi.org/10.1016/S0140-6736(17)32448-0

4. Khavkin AI, Nalyotov AV, Marchenko NA. Intestinal microbiota and microRNA in inflammatory bowel diseases: review of current data and future research prospects. Voprosy dietologii = Nutrition. 2023;13(4):55–63. (In Russ). https://doi.org/10.20953/2224-5448-2023-4-54-63

5. Serrano-Moreno C, Brox-Torrecilla N, Arhip L, et al. Diets for inflammatory bowel disease: What do we know so far? Eur J Clin Nutr. 2022;76(9):1222–1233. https://doi.org/10.1038/s41430-021-01051-9

6. Kucharzik T, Koletzko S, Kannengiesser K, Dignass A. Ulcerative colitis-diagnostic and therapeutic algorithms. Dtsch Arztebl Int. 2020;117(33-34):564–574. https://doi.org/10.3238/arztebl.2020.0564

7. Sachdeva V, Roy A, Bharadvaja N. Current prospects of nutraceuticals: A review. Curr Pharm Biotechnol. 2020;21(10):884–896. https://doi.org/10.2174/1389201021666200130113441

8. Perrone D, Ardito F, Giannatempo G, et al. Biological and therapeutic activities, and anticancer properties of curcumin. Exp Med. 2015;10(5):1615–1623. https://doi.org/10.3892/etm.2015.2749

9. European Food Safety Authority Panel on Food Additives and Nutrient Sources added to Food. Scientific Opinion on the re-evaluation of curcumin (E 100) as a food additive. EFSA J. 2010;8:1679.

10. Kharat M, Du Z, Zhang G, McClements DJ. Physical and chemical stability of curcumin in aqueous solutions and emulsions: impact of pH, temperature and molecular environment. J Agric Food Chem. 2017;65(8):1525–1532. https://doi.org/10.1021/acs.jafc.6b04815

11. Scazzocchio B, Minghetti L, D’Archivio M. Interaction between gut microbiota and curcumin: A new key of understanding for the health effects of curcumin. Nutrients. 2020;12(9):2499. https://doi.org/10.3390/nu12092499

12. Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011;108(16):6615–6620. https://doi.org/10.1073/pnas.1016217108

13. Tabanelli R, Brogi S, Calderone V. Improving curcumin bioavailability: Current strategies and future perspectives. Pharmaceutics. 2021;13(10):1715. https://doi.org/10.3390/pharmaceutics13101715

14. Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660–665. https://doi.org/10.1248/bpb.34.660

15. Schiborr C, Kocher A, Behnam D, et al. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014;58(3):516–527. https://doi.org/110.1002/mnfr.201300724

16. Wang Y, Tang Q, Duan P, Yang L. Curcumin as a therapeutic agent for blocking NFB activation in ulcerative colitis. Immunopharmacol. 2018;40(6):476–482. https://doi.org/10.1080/08923973.2018.1469145

17. Ng QX, Soh AYS, Loke W, et al. A Meta-analysis of the clinical use of curcumin for irritable bowel syndrome (IBS). J Clin Med. 2018;7(10):298. https://doi.org/10.3390/jcm7100298

18. Jabczyk M, Nowak J, Hudzik B, Zubelewicz-Szkodzińska B. Curcumin and its potential impact on microbiota. Nutrients. 2021;13(6):2004. https://doi.org/10.3390/nu13062004

19. Peterson CT, Vaughn AR, Sharma V, et al. Effects of turmeric and curcumin dietary supplementation on human gut microbiota: A double-blind, randomized, placebo-controlled pilot study. J Evid Based Integr Med. 2018;23:2515690X18790725. https://doi.org/10.1177/2515690X18790725

20. LeBlanc JF, Segal JP, de Campos Braz LM, Hart AL. The Microbiome as a therapy in pouchitis and ulcerative colitis. Nutrients. 2021;13(6):1780. https://doi.org/10.3390/nu13061780

21. McFadden RM, Larmonier CB, Shehab KW, et al. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis. 2015;21(11):2483–2494. https://doi.org/10.1097/MIB.0000000000000522

22. Ohno M, Nishida A, Sugitani Y, et al. Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PLoS One. 2017;12(10):e0185999. https://doi.org/10.1371/journal.pone.0185999

23. Chandan S, Mohan BP, Chandan OC, et al. Curcumin use in ulcerative colitis: Is it ready for prime time? A systematic review and meta-analysis of clinical trials. Ann Gastroenterol. 2020;33:53–58. https://doi.org/10.20524/aog.2019.0439

24. Zheng T, Wang X, Chen Z, et al. Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials. J Gastroenterol Hepatol. 2020;35(5):722–729. https://doi.org/10.1111/jgh.14911

25. Coelho MR, Romi MD, Ferreira DMTP, et al. The use of curcumin as a complementary therapy in ulcerative colitis: A systematic review of randomized controlled clinical trials. Nutrients. 2020;12(8):2296. https://doi.org/10.3390/nu12082296

26. Goulart RA, Barbalho SM, Rubira CJ, et al. Curcumin therapy for ulcerative colitis remission: Systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2020;14(12):1171–1179. https://doi.org/10.1080/17474124.2020.1808460

27. Yin J, Wei L, Wang N., et al. Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis. J Ethnopharmacol. 2022;289:115041. https://doi.org/10.1016/j.jep.2022.115041


Review

For citations:


Khavkin A.I., Naiyotov A.V. Curcumin as a Novel Trend in Adjunctive Therapy for Ulcerative Colitis. Pediatric pharmacology. 2024;21(6):534-538. (In Russ.) https://doi.org/10.15690/pf.v21i6.2840

Views: 256


ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)