Современные возможности применения дупилумаба у детей

Дупилумаб — это генно-инженерный иммунобиологический препарат, который в последние годы все чаще используется для лечения бронхиальной астмы (БА), атопического дерматита (АтД) и эозинофильного эзофагита (ЭЭ) у детей. Цель исследования — проанализировать современные литературные данные, посвященные применению дупилумаба в лечении БА, АтД и ЭЭ у детей. Несмотря на недолгую историю применения дупилумаба в педиатрической популяции, его использование показало многообещающие результаты при лечении множества состояний, в патогенезе которых лежит Т2-воспаление, в первую очередь БА, АтД и ЭЭ. Он продемонстрировал эффективность у пациентов с различными клиническими проявлениями, характеризующимися умеренным и тяжелым течением или рефрактерностью к лечению, и привел к улучшению качества жизни пациентов. С расширением применения дупилумаба появляется все больше данных о его полезности в лечении других заболеваний, опосредованных Т-клетками.

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