Genetic and Epigenetic Risk Factors for the Development of Simple Obesity in Children: a Literature Review
Anvar A. Dzhumagaziev,
Dina A. Bezrukova,
Natalia M. Shilina,
Natalia Yu. Otto,
Ekaterina V. Sosinovskaya,
A. V. Filipchuk https://doi.org/10.15690/pf.v21i6.2828
Abstract
Childhood obesity can be persisted into adulthood with a significant degree of probability. The origins of childhood obesity are multifaceted and continue to be intensively studied. Its massive spread over the past decades is primarily due to a violation of the balance between incoming and outgoing energy. The combination of genetic and epigenetic factors that can influence the formation of obesity is an interesting and developing area of research. A systematic review of the literature for 2013–2023 was conducted using eLibrary and PubMed. It has been found that the increase in the prevalence of childhood obesity in recent decades is associated with changes in human lifestyle, which lead to epigenetic changes in the genome. Decoding the interaction of genes with the environment, along with an individual genotype, will allow personalized prediction of obesity associated with a specific genome, epigenome and lifestyle, and the development of targeted preventive measures starting from the antenatal age.
About the Authors
Anvar A. Dzhumagaziev
Astrakhan State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Anvar A. Dzhumagaziev, MD, PhD, Professor
121, Bakinskaya Str., Astrakhan, 414000
Disclosure of interest:
Not declared
Dina A. Bezrukova
Astrakhan State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Dina A. Bezrukova, MD, PhD, Professor
Astrakhan
Disclosure of interest:
Not declared
Natalia M. Shilina
Federal Research Center of Nutrition, Biotechnology and Food Safety
Russian Federation
Disclosure of interest:
Russian Federation
Natalia M. Shilina, MD, PhD
Moscow
Disclosure of interest:
Not declared
Natalia Yu. Otto
Astrakhan State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Natalia Yu. Otto, MD
AstrakhanNot declared
Disclosure of interest:
Not declared
Ekaterina V. Sosinovskaya
Astrakhan State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Ekaterina V. Sosinovskaya, MD
Astrakhan
Disclosure of interest:
Not declared
A. V. Filipchuk
Astrakhan State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Anatoly V. Filipchuk, MD
Astrakhan
Disclosure of interest:
Not declared
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For citations:
Dzhumagaziev A.A., Bezrukova D.A., Shilina N.M., Otto N.Yu., Sosinovskaya E.V., Filipchuk A.V. Genetic and Epigenetic Risk Factors for the Development of Simple Obesity in Children: a Literature Review. Pediatric pharmacology. 2024;21(6):510-515. (In Russ.) https://doi.org/10.15690/pf.v21i6.2828
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