Cutaneous mastocytosis: Clinical Case
Aset Kh. Ibisheva,
Madina R. Shakhgireeva,
Linda V.-M. Dzhabrailova,
Asya B. Khildikharoeva,
Linda S. Uspanova,
A. A.-R. GetaevaKamila https://doi.org/10.15690/pf.v21i6.2811
Abstract
Skin syndrome is common in the practice of allergologist-immunologist, and it requires differential diagnosis. One of the rare skin diseases among children is mastocytosis caused by excessive accumulation of mast cells in various organs. Cutaneous Mastocytosis is the most common form in children. The disease onset may occur at any age. The pathognomonic symptom of mastocytosis is positive Darier sign. The presented clinical case demonstrates typical picture of cutaneous mastocytosis.
About the Authors
Aset Kh. Ibisheva
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
Aset Kh. Ibisheva, MD
101, Bisultanova Str., Grozny, 364028
Disclosure of interest:
Not declared
Madina R. Shakhgireeva
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
Madina R. Shakhgireeva, MD
Grozny
Disclosure of interest:
Not declared
Linda V.-M. Dzhabrailova
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
Linda V.-M. Dzhabrailova, MD
Grozny
Disclosure of interest:
Not declared
Asya B. Khildikharoeva
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
Asya B. Khildikharoeva, MD
Grozny
Disclosure of interest:
Not declared
Linda S. Uspanova
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
[Linda S. Uspanova, MD
Grozny
Disclosure of interest:
Not declared
A. A.-R. GetaevaKamila
Republican Children’s Clinical Hospital named after E.P. Glinka
Russian Federation
Disclosure of interest:
Russian Federation
Kamila A.-R. Getaeva, MD
Grozny
Disclosure of interest:
Not declared
References
1. Ahmed A, Jan A. Mastocytoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
2. Castells M, Metcalfe DD, Escribano L. Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations. Am J Clin Dermatol. 2011;12(4):259–270. https://doi.org/10.2165/11588890-000000000-00000
3. Hartmann K, Escribano L, Grattan C, et al. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol. 2016;137(1):35–45. https://doi.org/10.1016/j.jaci.2015.08.034
4. Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140(11):1200–1228. https://doi.org/10.1182/blood.2022015850
5. Swarnkar B, Sarkar R. Childhood Cutaneous Mastocytosis: Revisited. Indian J Dermatol. 2023;68(1):121. https://doi.org/10.4103/ijd.ijd_264_22
6. Markeson C, Metkowski A, Huang S, et al. Unusual presentation of maculopapular cutaneous mastocytosis in an infant with skin of color. JAAD Case Rep. 2023;38:105–107. https://doi.org/10.1016/j.jdcr.2023.02.025
7. Fokoloros C, Xepapadaki P, Papadavid E, et al. Mastocytosis in the Skin: Disease Heterogeneity among Children and Adults. Acta Derm Venereol. 2023;103:adv00845. https://doi.org/10.2340/actadv.v103.4461
8. Ługowska-Umer H, Czarny J, Rydz A, et al. Current Challenges in the Diagnosis of Pediatric Cutaneous Mastocytosis. Diagnostics (Basel). 2023;13(23):3583. https://doi.org/10.3390/diagnostics13233583
9. Rydz A, Lange M, Ługowska-Umer H, et al. Diffuse Cutaneous Mastocytosis: A Current Understanding of a Rare Disease. Int J Mol Sci. 2024;25(3):1401. doi: https://doi.org/10.3390/ijms25031401
10. Brockow K, Akin C, Huber M, et al. Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase. J Allergy Clin Immunol. 2002;109(1):82–88. https://doi.org/10.1067/mai.2002.120524
11. Meni C, Georgin-Lavialle S, Le Saché de Peufeilhoux L, et al. Paediatric mastocytosis: long-term follow-up of 53 patients with whole sequencing of KIT. A prospective study. Br J Dermatol. 2018;179(4):925–932. https://doi.org/10.1111/bjd.16795
12. Sathishkumar D, Balasundaram A, Mathew SM, et al. Clinicopathological Profile of Childhood Onset Cutaneous Mastocytosis from a Tertiary Care Center in South India. Indian Dermatol Online J. 2021;12(5):706–713. https://doi.org/10.4103/idoj.IDOJ_924_20
13. Sperr WR, Jordan JH, Fiegl M, et al. Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease. Int Arch Allergy Immunol. 2002;128(2):136–141. https://doi.org/10.1159/000059404
14. Lange M, Niedoszytko M, Renke J, et al. Clinical aspects of paediatric mastocytosis: a review of 101 cases. J Eur Acad Dermatol Venereol. 2013;27(1):97–102. https://doi.org/10.1111/j.1468-3083.2011.04365.x
15. Potapenko VG, Skoryukova KA. Children’s and adults’ mastocytosis: results of the analysis of the Russian patients group. Clinical pathophysiology. 2017;23(3):54–60. (In Russ).
16. Nemat K, Abraham S. Cutaneous mastocytosis in childhood. Allergol Select. 2022;6:1–10. https://doi.org/10.5414/ALX02304E
17. Mori F, Crisafulli G, Bianchi A, et al. Drugs and Vaccines Hypersensitivity in Children with Mastocytosis. J Clin Med. 2022;11(11):3153. https://doi.org/10.3390/jcm11113153
Review
For citations:
Ibisheva A.Kh., Shakhgireeva M.R., Dzhabrailova L.V., Khildikharoeva A.B., Uspanova L.S., GetaevaKamila A.A. Cutaneous mastocytosis: Clinical Case. Pediatric pharmacology. 2024;21(6):492-495. (In Russ.) https://doi.org/10.15690/pf.v21i6.2811
Views:
246
Email this article 