Hormone-producing Ovarian Tumors in Children. Literature Review
https://doi.org/10.15690/pf.v21i1.2710
Abstract
Hormone-producing ovarian tumors in girls are an actual problem in modern gynecology, which is associated with certain difficulties in managing patients. Firstly, it is worth taking into account the higher anatomical mobility of tumors in girls than in adults, due to the high location of the ovaries, weakness of the ligamentous apparatus and the active lifestyle of the child, which causes a higher incidence of torsion of the volumetric mass in children. Secondly, surgical treatment of hormone-producing ovarian tumors leads to a decrease in ovarian reserve and irreversible consequences in the reproductive health of patients in the future, which is an extremely undesirable complication in childhood. Therefore, methods of fertility preservation should be discussed with girls and their parents. It is also important to note that hormone-producing ovarian tumors have a certain degree of malignancy and a tendency to recur. Thus, the relevance of this topic lies in the complexity of management of pediatric patients with this pathology due to the clinical features of the course and a higher probability of complications. Hormone-producing ovarian masses should also include follicular cysts and corpus luteum cysts, but the above structures are excluded from the discussion in this article.
Keywords
About the Authors
Elena V. SibirskayaRussian Federation
MD, PhD, Professor.
117, Leninskiy avenue, Moscow, 119571
Disclosure of interest:
Not declared
Irina V. Karachentsova
Russian Federation
MD, PhD.
Moscow
Disclosure of interest:
Not declared
Angelina A. Sysoeva
Russian Federation
Student.
Moscow
Disclosure of interest:
Not declared
Mariia Yu. Chernysheva
Russian Federation
Student.
Moscow
Disclosure of interest:
Not declared
Kristina A. Osmanova
Russian Federation
Student.
Moscow
Disclosure of interest:
Not declared
Evgenia G. Kotikova
Russian Federation
Student.
Moscow
Disclosure of interest:
Not declared
References
1. Adamyan LV, Sibirskaya EV, Koltunov IE, et al. Tumours and tumour-like lesions of uterine adnexes encountered in the practical work of a pediatric gynecologist. Detskaya khirurgiya im. Yu.F. Isakova = Yu.F. Isakov Russian Journal of Pediatric Surgery. 2016;20(6):320–323. (In Russ). https://doi.org/10.18821/1560-9510-2016-20-6-320-323
2. Kokolina VF. Ginekologiya detskogo vozrasta. Moscow: ID Medpraktika-M; 2003. 268 p. (In Russ).
3. Hanafy AK, Mujtaba B, Yedururi S, et al. Imaging in pediat ric ovarian tumors. Abdom Radiol (NY). 2020;45(2):520–536. https://doi.org/10.1007/s00261-019-02316-5
4. Rishchuk SV, Mirskii VE, Kakhiani EI, et al. Osnovy detskoi i podrostkovoi ginekologii i andrologii: A textbook for doctors. St. Petersburg: Publishing house of North-Western State Medical University named after I.I. Mechnikov; 2017. — 224 p. (In Russ).
5. Javadi S, Ganeshan DM, Jensen CT, et al. Comprehensive review of imaging features of sex cord-stromal tumors of the ovary. Abdom Radiol (NY). 2021;46(4):1519–1529. https://doi.org/10.1007/s00261-021-02998-w
6. Kyurdzidi SO, Uvarova EV, Khashchenko EP, Kumykova ZKh. Modern principles of diagnosis and treatment of benign ovarian neoplasms in juveniles. Voprosy ginekologii akusherstva i perinatologii = Gynecology, Obstetrics and Perinatology. 2021;20(3):100–116. (In Russ). https://doi.org/10.20953/1726-1678-2021-3-100-116
7. Urmancheeva AF, Kutusheva GF, Ul’rikh EA. Opukholi yaichnika (klinika, diagnostika i lechenie). St. Petersburg: Publishing house N-L; 2012. pp. 5–19. (In Russ).
8. Baisova BI, Bizhanova DA, Boginskaya LN, et al. Ginekologiya: textbook. Savelyeva GM, Breusenko VG, eds. 4th ed., rev. and add. Moscow: GEOTAR-Media; 2012. 432 p. (In Russ).
9. Sibirskaya EV, Sharkov SM, Shostenko AV, Medvedeva AO. Malignant neoplasms of ovaries in children and adolescents. Detskaya khirurgiya = Russian Journal of Pediatric Surgery. 2018;22(5):258–262. (In Russ). doi: http//doi.org/10.18821/1560-9510-2018-22-5-258-262
10. Schultz KA, Schneider DT, Pashankar F, et al. Management of ovarian and testicular sex cord-stromal tumors in children and adolescents. J Pediatr Hematol Oncol. 2012;34(Suppl 2):S55–S63. doi: http//doi.org/10.1097/MPH.0b013e31824e3867
11. Thebaud E, Orbach D, Faure-Conter C, et al. Specificities of sex-cord stromal tumors in children and adolescents. Bull Cancer. 2015;102(6):550–558. doi: http//doi.org/10.1016/j.bulcan.2015.04.012
12. van Heerden J, Tjalma WA. The multidisciplinary approach to ovarian tumours in children and adolescents. Eur J Obstet Gynecol Reprod Biol. 2019;243:103–110. doi: http//doi.org/10.1016/j.ejogrb.2019.10.032
13. Adamyan LV, Koltunov IE, Sibirskaya EV, et al. Features of the differential diagnosis of ovarian tumors in girls (observa tion from the practice). Detskaya Khirurgya = Pediatric Surgery, Russian Journal. 2018;22(4):205–208. (In Russ). doi: http//doi.org/10.18821/1560-9510-2018-22-4-205-208
14. Sibirskaya EV, Adamyan LV, Yatsyk SP, Geras’kina SG. Abdominal pains in girls associated with a gynecological pathology: failures of diagnosis and treatment. Pediatricheskaya farmakologiya — Pediatric pharmacology. 2014;11(4):23–28. (In Russ). https://doi.org/10.15690/pf.v11i4.1059]
15. Adamyan LV, Sukhikh GT. Novye tekhnologii v diagnostike i lechenii ginekologicheskikh zabolevanii. Moscow: MEDI Ekspo; 2010. pp. 107–108. (In Russ).
16. Adamian LV, Bogdanova EA, Glybina TM, Sibirskaia EV. Gynecological origin of abdominal syndrome in children and teens. Russian Journal of Human Reproduction = Problemy Reproduktsii. 2011;17(1):38–34. (In Russ).
17. Ginekologiya: National leadership. Savel’eva GM, Sukhikh GT, Serov VN, et al., eds. 2nd ed., rev. and add. Moscow: GEOTAR-Media; 2022. 1008 p. (In Russ).
18. Conlon N, Schultheis AM, Piscuoglio S, et al. A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. Mod Pathol. 2015;28(12):1603–1612. https://doi.org/10.1038/modpathol.2015.115
19. Beggs AD, Latchford AR, Vasen HF, et al. Peutz-Jeghers syndrome: A systematic review and recommendations for management. Gut. 2010;59(7):975–986. https://doi.org/10.1136/gut.2009.198499
20. El Abiad JM, Robbins SM, Cohen B, et al. Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature. Am J Med Genet Part A. 2020;182(5):1093–1103. https://doi.org/10.1002/ajmg.a.61530
21. Adamyan LV, Sibirskaya EV, Korotkova SA, et al. Hormone-producing ovarian tumors in children (a clinical case of managing a patient with a granulosa cell tumor of the juvenile type). Russian Journal of Human Reproduction = Problemy Reproduktsii. (In Russ). https://doi.org/10.17116/repro20212705148
22. Umarova MN, Umarzoda SG, Akhmedova ZB. Malignant ovarian tumors of childhood and adolescence: features of diagnosis, clinical course and treatment. Vestnik Akademii meditsinskikh nauk Tadzhikistana. 2020;10(4):402–411. (In Russ). https://doi.org/10.31712/2221-7355-2020-10-4-402-411
23. Kota S, Pani J, Kota S, et al. Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl. Indian J Endocrinol Metab. 2012;16(5):836–839. https://doi.org/10.4103/2230-8210.100658
24. Bús D, Buzogány M, Nagy G, Vajda G. Rare virilizing granulosa cell tumor in an adolescent. Mol Clin Oncol. 2017;6(1):88–90. https://doi.org/10.3892/mco.2016.1084
25. Gui T, Cao D, Shen K, et al. A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol Oncol. 2012;127(2):384–389. https://doi.org/10.1016/j.ygyno.2012.07.114
26. Durmuş Y, Kılıç Ç, Çakır C, et al. Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature. J Obstet Gynaecol Res. 2019;45(7):1311–1318. https://doi.org/10.1111/jog.13977
27. Hossain F, Karim MN, Rahman SM, et al. Preoperative detection of ovarian cancer by color Doppler ultrasonography and CA 125. Bangladesh Med Res Counc Bull. 2010;36(2):68–73. https://doi.org/10.3329/bmrcb.v36i2.6991
28. Adamyan LV, Dyakonova EYu, Sibirskaya EV, et al. Surgical approach in cases of adnexal torsion in children. Pediatric and adolescent reproductive health. 2014;(4):35–41. (In Russ).
29. Andreotti RF, Timmerman D, Strachowski LM, et al. O-RADS US Risk Stratification and Management System: A Consensus Guideline from the ACR Ovarian-Adnexal Reporting and Data System Committee. Radiology. 2020;294(1):168–185. https://doi.org/10.1148/radiol.2019191150
30. Neepitelial’nye opukholi yaichnikov: Clinical guidelines. 2022. (In Russ).
31. Diagnostika i lechenie dobrokachestvennykh novoobrazovanii yaichnikov s pozitsii profilaktiki raka: Clinical guidelines. 2018. (In Russ).
32. Rak yaichnikov, rak matochnoi truby, pervichnyi rak bryushiny: Clinical guidelines. 2022. (In Russ).
33. Liu J, Xu Y, Wang J. Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis of ovarian carcinoma. Eur J Radiol. 2007;62(3):328–334. https://doi.org/10.1016/j.ejrad.2007.02.040
34. Van Nimwegen LWE, Mavinkurve-Groothuis AMC, de Krijger RR, et al. MR imaging in discriminating between benign and malignant paediatric ovarian masses: a systematic review. Eur Radiol. 2020;30(2):1166–1181. https://doi.org/10.1007/s00330019-06420-4
35. Levin G, Zigron R, Haj-Yahya R, et al. Granulosa cell tumor of ovary: A systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol. 2018;225:57–61. https://doi.org/10.1016/j.ejogrb.2018.04.002
36. Akakpo PK, Derkyi-Kwarteng L, Quayson SE, et al. Ovarian Tumors in Children and Adolescents: A 10-Yr Histopathologic Review in KorleBu Teaching Hospital, Ghana. Int J Gynecol Pathol. 2016;35(4):333– 336. https://doi.org/10.1097/PGP.0000000000000257
37. Oue T, Uehara S, Sasaki T, et al. Treatment and ovarian preservation in children with ovarian tumors. J Pediatr Surg. 2015;50(12):2116– 2118. https://doi.org/10.1016/j.jpedsurg.2015.08.036
38. Pectasides D, Pectasides E, Kassanos D. Germ cell tumors of the ovary. Cancer Treat Rev. 2008;34(5):427–441. https://doi.org/10.1016/j.ctrv.2008.02.002
39. Ali A, Sayed H, Salem M, et al. Clinicopathological pattern and outcome of pediatric malignant ovarian germ cell tumors: South Egypt Cancer Institute experience. J Pediatr Surg. 2018;53(4):837–840. doi: https://doi.org/10.1016/j.jpedsurg.2017.08.022
40. Zhang R, Sun YC, Zhang GY, et al. Treatment of malignant ovarian germ cell tumors and preservation of fertility. J Eur J Gynaecol Oncol. 2012;33(5):489–492.
41. Kavanagh JJ, Pecorelli S, Benedet J, et al. Cancer of the ovary. In: Staging classifications and clinical practice guidelines for gynaecological cancers. Benedet J, Pecorelli S, Ngan HY, Hacker NF, eds. Elsevier; 2006. pp. 95–121.
42. Chaopotong P, Therasakvichya S, Leelapatanadit C, et al. Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes. Asian Pac J Cancer Prev. 2015;16(11):4787–4790. https://doi.org/10.7314/apjcp.2015.16.11.4787
43. Burns K, Hoefgen H, Strine A, Dasqupta R. Fertility preservation options in pediatric and adolescent patients with cancer. Cancer. 2018;124(9):1867–1876. https://doi.org/10.1002/cncr.31255
44. Resetkova N, Hayashi M, Kolp LA, Christianson MS. Fertility preservation for prepubertal girls: Update and current challenges. Curr Obstet Gynecol Rep. 2013;2(4):218–225. https://doi.org/10.1007/s13669-013-0060-9
45. Zhang R, Sun YC, Zhang GY, et al. Treatment of malignant ovarian germ cell tumors and preservation of fertility. J Eur J Gynaecol Oncol. 2012;33(5):489–492.
46. Kavanagh JJ, Pecorelli S, Benedet J, et al. Cancer of the ovary. In: Staging classifications and clinical practice guidelines for gynaecological cancers. Benedet J, Pecorelli S, Ngan HY, Hacker NF, eds. Elsevier; 2006. pp. 95–121.
47. Chaopotong P, Therasakvichya S, Leelapatanadit C, et al. Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes. Asian Pac J Cancer Prev. 2015;16(11):4787–4790. https://doi.org/10.7314/apjcp.2015.16.11.4787
48. Burns K, Hoefgen H, Strine A, Dasqupta R. Fertility preservation options in pediatric and adolescent patients with cancer. Cancer. 2018;124(9):1867–1876. https://doi.org/10.1002/cncr.31255
49. Resetkova N, Hayashi M, Kolp LA, Christianson MS. Fertility preservation for prepubertal girls: Update and current challenges. Curr Obstet Gynecol Rep. 2013;2(4):218–225. https://doi.org/10.1007/s13669-013-0060-9
Review
For citations:
Sibirskaya E.V., Karachentsova I.V., Sysoeva A.A., Chernysheva M.Yu., Osmanova K.A., Kotikova E.G. Hormone-producing Ovarian Tumors in Children. Literature Review. Pediatric pharmacology. 2024;21(1):41-49. (In Russ.) https://doi.org/10.15690/pf.v21i1.2710